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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alzheimer's disease
Summary
- Synonym
-
- Alzheimer disease
- Alzheimers dementia
- Definition
- A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
- Super Class
- tauopathy
External Links
- Disease Ontology
- DOID:10652
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
-
- 2174818
- 2174917
- 2174969
- 2174990
- 2174994
- 2174998
- 2177097
- 2177120
- 2652360
- 2652361
- 2652362
- 2652363
- 2652447
- 2652553
- 2662716
- 2684657
- 3029285
- 3044184
- 3045183
- 3045186
- 3510652
- 3577843
- 3582996
- 3589555
- 3611210
- 3611211
- 3618601
- 3624416
- 3639711
- 3639713
- 3653709
- 3663447
- 3663620
- 3663621
- 3663749
- 3663751
- 3665286
- 3665287
- 3693295
- 3693439
- 3693440
- 3693491
- 3696575
- 3696576
- 3697817
- 3702925
- 3709152
- 3709154
- 3709182
- 3710761
- 3710763
- 3710766
- 3717255
- 3717577
- 3718076
- 3718515
- 3720208
- 3720209
- 3720676
- 3720677
- 3720700
- 3720701
- 3720702
- 3720731
- 3720782
- 3720946
- 3721530
- 3721531
- 3721541
- 3721542
- 3721938
- 3722063
- 3722101
- 3722102
- 3722143
- 3722160
- 3722393
- 3769910
- 3771317
- 3784684
- 3829507
- 4355229
- 4355230
- 4366531
- 4367205
- 4367786
- 4412051
- 4417912
- 4438223
- 4818990
- 4819951
- 4843219
- 4847595
- 4882081
- 4943741
- 5003275
- 5003459
- 5003460
- 5003461
- 5003462
- 5003463
- 5003464
- 5003501
- 5008417
- 5008418
- 5014041
- 5050413
- 5051941
- 5051942
- 5052112
- 5052119
- 5052120
- 5140748
- 5294357
- 5294359
- 5301407
- 5305067
- 5313530
- 5427915
- 5428425
- 5433612
- 5433613
- 5435319
- 5442379
- 5462366
- 5463430
- 5463438
- 5465558
- 5471581
- 5491627
- 5511058
- 5512698
- 5512699
- 5521287
- 5550547
- 5550582
- 5553465
- 5554193
- 5559229
- 5559449
- 5569760
- 5578629
- 5581429
- 5581681
- 5604616
- 5629689
- 5634332
- 5638672
- 5638675
- 5646171
- 5646215
- 5699096
- 5701399
- 5708587
- 5754382
- 5754385
- 5755045
- 5790841
- 5792143
- 5803810
- 5811870
- 5812135
- 5829782
- 6257021
- 6257025
- 6314698
- 6324682
- 6392258
- 7608058
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 5444 | PON1 | paraoxonase 1 | |
| 5445 | PON2 | paraoxonase 2 | |
| 5446 | PON3 | paraoxonase 3 | |
| 5465 | PPARA | peroxisome proliferator activated receptor alpha | |
| 5468 | PPARG | peroxisome proliferator activated receptor gamma | |
| 5601 | MAPK9 | mitogen-activated protein kinase 9 | |
| 5610 | EIF2AK2 | eukaryotic translation initiation factor 2 alpha kinase 2 | |
| 5649 | RELN | reelin | |
| 5653 | KLK6 | kallikrein related peptidase 6 | |
| 5705 | PSMC5 | proteasome 26S subunit, ATPase 5 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 13628 | Eef1a2 | eukaryotic translation elongation factor 1 alpha 2 | |
| 13629 | Eef2 | eukaryotic translation elongation factor 2 | |
| 13645 | Egf | epidermal growth factor | |
| 13653 | Egr1 | early growth response 1 | |
| 13665 | Eif2s1 | eukaryotic translation initiation factor 2, subunit 1 alpha | |
| 13712 | Elk1 | ELK1, member of ETS oncogene family | |
| 13806 | Eno1 | enolase 1, alpha non-neuron | |
| 13838 | Epha4 | Eph receptor A4 | |
| 13849 | Ephx1 | epoxide hydrolase 1, microsomal | |
| 13856 | Epo | erythropoietin |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24628 | Pdgfb | platelet derived growth factor subunit B | |
| 24655 | Plcd1 | phospholipase C, delta 1 | |
| 24714 | Reg1a | regenerating family member 1 alpha | |
| 24718 | Reln | reelin | |
| 24778 | Slc2a1 | solute carrier family 2 member 1 | |
| 24787 | Sod2 | superoxide dismutase 2 | |
| 24804 | Syp | synaptophysin | |
| 24835 | Tnf | tumor necrosis factor | |
| 24854 | Clu | clusterin | |
| 24856 | Ttr | transthyretin |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31002 | Appl | beta amyloid protein precursor-like | |
| 31248 | sgg | shaggy | |
| 31293 | N | Notch | |
| 31364 | Fas2 | Fasciclin 2 | |
| 31547 | Nep1 | Neprilysin 1 | |
| 31792 | Nrg | Neuroglian | |
| 32342 | amrt | amaretto | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 33005 | Nep3 | Neprilysin 3 | |
| 33007 | Dop2R | Dopamine 2-like receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30262 | ins | preproinsulin | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 30705 | fgfr1a | fibroblast growth factor receptor 1a | |
| 30718 | notch1a | notch receptor 1a | |
| 58133 | ngfb | nerve growth factor b (beta polypeptide) | |
| 114549 | ache | acetylcholinesterase (Yt blood group) | |
| 317743 | gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 394082 | slc18a3b | solute carrier family 18 member 3b | |
| 406367 | gapdhs | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | |
| 436913 | tm2d2 | TM2 domain containing 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373644 | ldlr.S | low density lipoprotein receptor S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378605 | htr1a.L | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog | Xenopus laevis (African clawed frog) | |
| 380259 | gapdh.S | glyceraldehyde-3-phosphate dehydrogenase S homeolog | Xenopus laevis (African clawed frog) | |
| 380298 | eno1.S | enolase 1 S homeolog | Xenopus laevis (African clawed frog) | |
| 380307 | bace2.L | beta-secretase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 397713 | psen2.S | presenilin 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397757 | ldlr.L | low density lipoprotein receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171905 | ace-2 | Carboxylic ester hydrolase | |
| 171999 | poml-2 | Arylesterase | |
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 172689 | sup-17 | Disintegrin and metalloproteinase domain-containing protein 10 homolog | |
| 172703 | unc-29 | Acetylcholine receptor subunit beta-type unc-29 | |
| 172905 | aph-2 | Nicastrin | |
| 173685 | nep-11 | Neprilysin-11 | |
| 173794 | vab-1 | Ephrin receptor 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850812 | YPS3 | aspartyl protease | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
| 851950 | YPS7 | putative aspartic endopeptidase | |
| 852264 | PEP1 | type I sorting receptor | |
| 852543 | VVS1 | Vvs1p | |
| 852702 | XRN1 | chromatin-binding exonuclease XRN1 | |
| 852806 | HSF1 | stress-responsive transcription factor HSF1 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853169 | ENO1 | phosphopyruvate hydratase ENO1 | |
| 853233 | VTH2 | signal sequence-binding protein |
