acute chest syndrome

Summary
Synonym
  • acute chest syndrome in sickle cell disease
Definition
A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
Super Class
lung disease
External Links
Disease Ontology
DOID:1584
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
Related Genes
Displaying entries 11 - 20 of 51 in total
Gene ID Gene Symbol Description Source
1557 CYP2C19 cytochrome P450 family 2 subfamily C member 19
1576 CYP3A4 cytochrome P450 family 3 subfamily A member 4
1577 CYP3A5 cytochrome P450 family 3 subfamily A member 5
1636 ACE angiotensin I converting enzyme
2053 EPHX2 epoxide hydrolase 2
2194 FASN fatty acid synthase
2215 FCGR3B Fc gamma receptor IIIb
2539 G6PD glucose-6-phosphate dehydrogenase
2645 GCK glucokinase
3383 ICAM1 intercellular adhesion molecule 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024