acute chest syndrome

Summary
Synonym
  • acute chest syndrome in sickle cell disease
Definition
A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
Super Class
lung disease
External Links
Disease Ontology
DOID:1584
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
Related Genes
Displaying entries 31 - 40 of 51 in total
Gene ID Gene Symbol Description Source
5321 PLA2G4A phospholipase A2 group IVA
5332 PLCB4 phospholipase C beta 4
5742 PTGS1 prostaglandin-endoperoxide synthase 1
5743 PTGS2 prostaglandin-endoperoxide synthase 2
6401 SELE selectin E
6402 SELL selectin L
6403 SELP selectin P
7412 VCAM1 vascular cell adhesion molecule 1
7941 PLA2G7 phospholipase A2 group VII
8398 PLA2G6 phospholipase A2 group VI

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024