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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 4153 | MBL2 | mannose binding lectin 2 | |
| 4360 | MRC1 | mannose receptor C-type 1 | |
| 4907 | NT5E | 5'-nucleotidase ecto | |
| 4968 | OGG1 | 8-oxoguanine DNA glycosylase | |
| 5290 | PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | |
| 5291 | PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | |
| 5293 | PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | |
| 5294 | PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | |
| 5319 | PLA2G1B | phospholipase A2 group IB | |
| 5320 | PLA2G2A | phospholipase A2 group IIA |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11554 | Adrb1 | adrenergic receptor, beta 1 | |
| 12654 | Chi3l1 | chitinase 3 like 1 | |
| 15558 | Htr2a | 5-hydroxytryptamine (serotonin) receptor 2A | |
| 16846 | Lep | leptin | |
| 16847 | Lepr | leptin receptor | |
| 17082 | Il1rl1 | interleukin 1 receptor-like 1 | |
| 19017 | Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | |
| 21898 | Tlr4 | toll-like receptor 4 | |
| 21926 | Tnf | tumor necrosis factor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24536 | Lepr | leptin receptor | |
| 24835 | Tnf | tumor necrosis factor | |
| 24925 | Adrb1 | adrenoceptor beta 1 | |
| 25556 | Il1rl1 | interleukin 1 receptor-like 1 | |
| 25608 | Lep | leptin | |
| 29260 | Tlr4 | toll-like receptor 4 | |
| 29595 | Htr2a | 5-hydroxytryptamine receptor 2A | |
| 83516 | Ppargc1a | PPARG coactivator 1 alpha | |
| 89824 | Chi3l1 | chitinase 3 like 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 34978 | Idgf1 | Imaginal disc growth factor 1 | |
| 34979 | Idgf2 | Imaginal disc growth factor 2 | |
| 34981 | Idgf3 | Imaginal disc growth factor 3 | |
| 36868 | Idgf6 | Imaginal disc growth factor 6 | |
| 37104 | Idgf5 | Imaginal disc growth factor 5 | |
| 43222 | Tl | Toll |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P22897 | Macrophage mannose receptor 1 | |
| P23219 | Prostaglandin G/H synthase 1 | |
| P26718 | NKG2-D type II integral membrane protein | |
| P27797 | Calreticulin | |
| P28845 | 11-beta-hydroxysteroid dehydrogenase 1 | |
| P28907 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | |
| P31431 | Syndecan-4 | |
| P34059 | N-acetylgalactosamine-6-sulfatase | |
| P34913 | Bifunctional epoxide hydrolase 2 | |
| P35247 | Pulmonary surfactant-associated protein D |
