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MIRAGE
Lymphotoxin-alpha

Summary
UniProt ID
P01374
Gene Symbol
  • LTA
  • TNFB
  • TNFSF1
Gene ID
4049
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01374
PubChem
P01374
Re-Glyco
P01374
Annotation
Keyword
  • 3D-structure
  • Cytokine
  • Direct protein sequencing
  • Glycoprotein
  • Membrane
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 2 entries
GO Term
extracellular space
plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
41 O-linked (GalNAc...) threonine; partial
96 N-linked (GlcNAc...) asparagine
Feature
204060801001201401601802001205
20406080100120140160180200MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
Domains & sites
PTM
ProtVista
20406080100120140160180200MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Homo sapiens
TNFR2 non-canonical NF-kB pathway Homo sapiens
TNFs bind their physiological receptors Homo sapiens
Disease
Displaying entries 11 - 20 of 32 in total
DO ID Disease Name Source
DOID:1380 endometrial cancer
DOID:1485 cystic fibrosis
DOID:1612 breast cancer
DOID:2018 hyperinsulinism
DOID:2841 asthma
DOID:2957 pulmonary tuberculosis
DOID:3070 high grade glioma
DOID:3393 coronary artery disease
DOID:3407 carotid artery disease
DOID:3526 cerebral infarction
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025