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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
High affinity immunoglobulin gamma Fc receptor I
Summary
- UniProt ID
- P12314
- Gene Symbol
-
- FCGR1A
- FCG1
- FCGR1
- IGFR1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- IgG-binding protein
- Immunoglobulin domain
- Innate immunity
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| phagocytosis, recognition |
| phagocytosis, engulfment |
| Fc-gamma receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| GO Term |
|---|
| external side of plasma membrane |
| plasma membrane |
| clathrin-coated endocytic vesicle membrane |
| early endosome membrane |
| GO Term |
|---|
| high-affinity IgG receptor activity |
| IgG receptor activity |
| IgG binding |
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 59 | N-linked (GlcNAc...) asparagine |
|
||
| 78 | N-linked (GlcNAc...) asparagine |
|
||
| 152 | N-linked (GlcNAc...) asparagine |
|
||
| 159 | N-linked (GlcNAc...) asparagine |
|
||
| 163 | N-linked (GlcNAc...) asparagine |
|
||
| 195 | N-linked (GlcNAc...) asparagine |
|
||
| 240 | N-linked (GlcNAc...) asparagine |
|
||
|
|
|
G62326NX
G90093AU
G26915XM
G17689DH
G22310AV
G72797UR
G63381RX
G72667IM
G84452RH
G96095QD
G25520XG
G91636VS
G93141AZ
G70418MS
G03382KH
G90717TP
G23863VK
G78059CC
G74430RZ
G31916IQ
G64527OM
G23432EQ
G72902CL
G46687AB
G62389NM
G82119TF
G72291OX
G05724UK
G29011JC
G31936TA
G49874UX
G80858MF
G39188ZX
G39213VZ
G06110VR
G55220VL
G60145BJ
G96771UL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cross-presentation of soluble exogenous antigens (endosomes) | Homo sapiens |
| FCGR activation | Homo sapiens |
| FCGR3A-mediated IL10 synthesis | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
| Interferon gamma signaling | Homo sapiens |
| Regulation of actin dynamics for phagocytic cup formation | Homo sapiens |
| Role of phospholipids in phagocytosis | Homo sapiens |
