Ubiquitin-dependent degradation of Cyclin D
|
|
|
- CCND1
- CDK4
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA8
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMB8
- PSMB9
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME4
- PSMF1
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Hedgehog ligand biogenesis
|
|
|
- DERL2
- DHH
- ERLEC1
- HHAT
- IHH
- OS9
- P4HB
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA8
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMB8
- PSMB9
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME4
- PSMF1
- RPS27A
- SEL1L
- SHH
- SUG1
- SYVN1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VCP
|
|
Asymmetric localization of PCP proteins
|
|
|
- DVL2
- FZD1
- FZD2
- FZD3
- FZD5
- FZD7
- FZD8
- PARD6A
- PRICKLE1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA8
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMB8
- PSMB9
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME4
- PSMF1
- RPS27A
- SMURF1
- SMURF2
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WNT5A
|
|
AUF1 (hnRNP D0) binds and destabilizes mRNA
|
|
|
- EIF4G1
- HNRNPD
- HSC70
- HSP27
- HSP70-1
- HSPA1A
- HSPA8
- HSPB1
- PABP1
- PABPC1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA8
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMB8
- PSMB9
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME4
- PSMF1
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Mineralocorticoid biosynthesis
|
|
|
- CGA
- CYP11B1
- CYP21
- CYP21A1
- CYP21A2
- HSD3B
- LHB
|
|
Cytosolic sulfonation of small molecules
|
|
|
- ABHD14B
- BPNT1
- BPNT2
- LOC100300896
- PODXL2
- STP
- SULT1A1
- SULT1B1
- SULT1C2
- SULT1E1
- SULT2A1
- SULT2B1
- SULT4A1
- SULT6B1
- TPST1
- TPST2
|
|
Fatty acyl-CoA biosynthesis
|
|
|
- ACACA
- ACLY
- CBR4
- FABGL
- FASN
- HKE6
- HSD17B8
- MORC2
- PPT1
- PPT2
- SCD
- SCD5
- SLC27A2
|
|
PI3K/AKT Signaling
|
|
|
- AFGF
- AREG
- BTC
- CD19
- CD28
- CD80
- CD86
- EGFR
- EPGN
- ERBB2
- ERBB3
- ERBB4
- EREG
- ESR
- ESR1
- ESR2
- FGF1
- FGF10
- FGF16
- FGF17
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF3
- FGF4
- FGF4A
- FGF4C
- FGF5
- FGF5B
- FGF5C
- FGF6
- FGF6A
- FGF7
- FGF7B
- FGF8
- FGF8A
- FGF9
- FGFA
- FGFR1
- FGFR2
- FGFR3
- FGFR4
- FLT3
- FLT3LG
- FRS2
- FYN
- Fgf4
- GAB1
- GAB2
- GRB2
- HBEGF
- HBGF-1
- HGF
- ICOS
- IL1RL1
- IL33
- IRAK1
- IRAK4
- IRS1
- IRS2
- KIT
- KITLG
- KL
- KLB
- LCK
- MET
- MYD88
- NR3A1
- NR3A2
- NRG1
- NRG2
- NRG3
- PDGFA
- PDGFB
- PDGFRA
- PDGFRB
- PDPK1
- PIK3AP1
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3R1
- PIK3R2
- PIK3R3
- PTPN11
- RAC2
- RHOG
- SCF
- SRC
- STRN
- TGFA
- TRAF6
- TRAT1
- VAV1
|
|
VEGFR2 mediated vascular permeability
|
|
|
- CALM
- CAV1
- CDH5
- CTNNA1
- CTNNB1
- CTNND1
- HSP90A
- HSP90AA1
- HSPCA
- JUP
- NOS3
- PAK1
- PAK2
- PAK3
- PDPK1
- VAV1
- VAV2
- VAV3
|
|
Glyoxylate metabolism and glycine degradation
|
|
|
- AGXT
- AGXT2
- ALDH4A1
- DAO
- DHDPSL
- GNMT
- GOT2
- GRHPR
- HAO1
- HOGA1
|
|
Mitochondrial protein import
|
|
|
- AAC1
- AAC3
- ANT1
- ANT3
- ATP5F1B
- ATP5G1
- ATP5G3
- ATP5MC1
- ATP5MC3
- COQ2
- FRDA
- FXN
- HSCB
- HSPD1
- LDHD
- NDUFB8
- OTC
- PITRM1
- SLC25A4
- SLC25A6
- TAFAZZIN
- TAZ
- TIM10
- TIM22
- TIM23
- TIMM10
- TIMM17A
- TIMM17B
- TIMM22
- TIMM23
- TIMM9
|
|
Regulation of TP53 Activity through Phosphorylation
|
|
|
- AIK
- AIRK1
- ARK1
- ATM
- ATR
- ATRIP
- AURA
- AURKA
- AURKB
- AYK1
- BARD1
- BLM
- BRCA1
- BRIP1
- BTAK
- CCNA1
- CCNA2
- CDK2
- CDK5
- CDK5R
- CDK5R1
- CDKN2
- CDKN5
- CHEK2
- CK2A1
- CK2N
- CSNK2A1
- CSNK2A2
- CSNK2B
- DNA2
- DYRK2
- EXO1
- HIPK1
- HIPK2
- HUS1
- IAK1
- KAT5
- MAPK11
- MAPK14
- MAPKAPK5
- MDM2
- MRE11
- NBN
- NCK5A
- NIR
- NOC2L
- NUAK1
- PIN1
- PLK3
- PRKAA1
- PRKAA2
- PRKAB1
- PRKAB2
- PRKAG1
- PRKAG2
- PRKAG3
- PSSALRE
- RAD1
- RAD17
- RAD50
- RAD9A
- RAD9B
- RBBP8
- RFC2
- RFC3
- RFC5
- RHNO1
- RMI1
- RMI2
- RPA1
- RPA2
- RPA3
- RPS27A
- SSRP1
- STK11
- STK15
- STK6
- SUPT16H
- TAF1
- TAF10
- TAF11
- TAF12
- TAF15
- TAF2
- TAF3
- TAF4
- TAF4B
- TAF5
- TAF6
- TAF7L
- TAF9
- TAF9B
- TBP
- TOP3A
- TOPBP1
- TP53
- TP53INP1
- TP53RK
- TPX2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WRN
|
|
Macroautophagy
|
|
|
- AMBRA1
- APG4B
- ATG10
- ATG101
- ATG12
- ATG13
- ATG14
- ATG16L1
- ATG3
- ATG4A
- ATG4B
- ATG4C
- ATG4D
- ATG5
- ATG7
- ATG9
- ATG9A
- ATG9B
- AUT2B
- BECN1
- CHMP2A
- CHMP2B
- CHMP3
- CHMP4A
- CHMP4B
- CHMP4C
- CHMP6
- CHMP7
- DNCL1
- DYNLL1
- DYNLL2
- GABARAP
- GABARAPL1
- GABARAPL2
- GBL
- GEF2
- LAMTOR1
- LAMTOR2
- LAMTOR3
- LAMTOR4
- LAMTOR5
- LST8
- MAP1ALC3
- MAP1LC3
- MAP1LC3A
- MAP1LC3B
- MAP1LC3C
- MGC138057
- MLST8
- MTMR14
- MTOR
- PIK3C3
- PIK3R4
- PRKAA1
- PRKAA2
- PRKAB1
- PRKAB2
- PRKAG1
- PRKAG2
- PRKAG3
- RB1CC1
- RHEB
- RPTOR
- RRAGA
- RRAGB
- RRAGC
- RRAGD
- SLC38A9
- TSC1
- ULK1
- UVRAG
- VPS24
- WDR45
- WDR45B
- WIPI1
- WIPI2
|
|
Nuclear events mediated by NFE2L2
|
|
|
- CREBBP
- EP300
- NFE2L2
- PRKAA2
|
|
G alpha (i) signalling events
|
|
|
- ACKR3
- ADORA1
- ADORA3
- ADRA2A
- ADRA2B
- ADRA2C
- AGT
- AGTR2
- APLN
- APLNR
- BCP
- BDKRB2
- C3
- C3AR1
- C5
- C5AR1
- CASR
- CCL1
- CCL19
- CCL20
- CCL21
- CCL25
- CCL27
- CCL28
- CCL4
- CCL5
- CCR1
- CCR10
- CCR3
- CCR4
- CCR5
- CCR6
- CCR8
- CCR9
- CHRM2
- CMKBR5
- CNR1
- CNR2
- CORT
- CX3CR1
- CXCL10
- CXCL11
- CXCL12
- CXCL13
- CXCL16
- CXCL3
- CXCL6
- CXCL8
- CXCL9
- CXCR1
- CXCR2
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
- DRD3
- GABBR1
- GABBR2
- GAL
- GALN
- GALR1
- GALR2
- GALR3
- GCP2
- GNAI1
- GNAI2
- GNAI3
- GNAT1
- GNAT2
- GNAT3
- GNB1
- GNB2
- GNB3
- GNB4
- GNB5
- GNG10
- GNG11
- GNG12
- GNG13
- GNG2
- GNG3
- GNG4
- GNG5
- GNG7
- GNG8
- GNGT1
- GNGT12
- GNGT2
- GNGT3
- GNGT5
- GNGT7
- GNGT8
- GPR17
- GPR18
- GPR183
- GPR31
- GPR37
- GPR37L1
- GPR8
- GPR92
- GPRC2A
- GPSM1
- GPSM2
- GRM2
- GRM3
- GRM4
- GRM6
- GRM7
- GRM8
- HCAR1
- HRH4
- HTR1B
- HTR1D
- HTR1E
- HTR1F
- HTR5A
- IL8
- KNG1
- LOC782957
- LPAR1
- LPAR2
- LPAR3
- LPAR5
- MCHR1
- MCHR2
- MIP3A
- MTNR1A
- MTNR1B
- NMS
- NMUR1
- NMUR2
- NPB
- NPBWR1
- NPBWR2
- NPY
- NPY1R
- NPY2R
- NPY4R
- NPY5R
- OPN1LW
- OPN1SW
- OPN5
- OPRD1
- OPRK1
- OPRL1
- OPRM1
- OXER1
- OXGR1
- P2RY12
- P2RY14
- P2RY4
- PBX2
- PCAR1
- PCP2
- PDYN
- PENK
- PMCH
- PNOC
- POMC
- PPBP
- PPY
- PPYR1
- PSAP
- PTGDR2
- PTGER3
- PYY
- RCP
- RGR
- RGS1
- RGS11
- RGS13
- RGS14
- RGS16
- RGS17
- RGS18
- RGS19
- RGS20
- RGS21
- RGS3
- RGS4
- RGS5
- RGS6
- RGS7
- RGS8
- RGS9
- RHO
- RRH
- S1PR2
- S1PR3
- S1PR5
- SCY4A
- SCYA20
- SCYA5
- SCYB6
- SERPINA8
- SRC
- SST
- SSTR1
- SSTR2
- SSTR5
- SUCNR1
- T2R10C
- T2R65A
- TAS1R1
- TAS1R2
- TAS1R3
- TAS2R1
- TAS2R16
- TAS2R3
- TAS2R39
- TAS2R4
- TAS2R40
- TAS2R42
- TAS2R46
- TAS2R60
- TAS2R7
- TAS2R8
- gpr81
|
|
Neurotransmitter receptors and postsynaptic signal transmission
|
|
|
- GLRA1
- GLRA2
- GLRA3
- GLRB
- HTR3A
- HTR3B
- LOC616094
|
|
G alpha (s) signalling events
|
|
|
- ADCYAP1
- ADCYAP1R1
- ADM
- ADORA2A
- ADORA2B
- ADRB1
- ADRB2
- ADRB3
- ADRBK1
- ADRBK2
- ARRB1
- ARRB2
- AVP
- AVPR2
- CALC3
- CALCA
- CALCB
- CALCR
- CALCRL
- CGA
- CRH
- CRHR2
- CT
- D1AR
- DRD1
- DRD5
- FSHB
- FSHR
- GCG
- GCGR
- GHRH
- GHRHR
- GIP
- GIPR
- GLP2R
- GNB1
- GNB2
- GNB3
- GNB4
- GNB5
- GNG10
- GNG11
- GNG12
- GNG13
- GNG2
- GNG3
- GNG4
- GNG5
- GNG7
- GNG8
- GNGT1
- GNGT12
- GNGT2
- GNGT3
- GNGT5
- GNGT7
- GNGT8
- GPA2
- GPB5
- GPBAR1
- GPHA2
- GPHB5
- GPR15
- GPR176
- GPR20
- GPR25
- GPR39
- GPR83
- GPR84
- GPRK5
- GRK2
- GRK3
- GRK5
- GRK6
- HRH2
- HTR4
- HTR6
- HTR7
- IAPP
- INSL3
- LHB
- LHCGR
- LOC511136
- LOC516101
- MC1R
- MC2R
- MC3R
- MC4R
- MC5R
- MSHR
- NPS
- NPSR1
- P2RY11
- PDE10A
- PDE11A
- PDE1A
- PDE1B
- PDE2A
- PDE3A
- PDE3B
- PDE4A
- PDE4C
- PDE4D
- PDE7B
- PDE8A
- PDE8B
- POMC
- PTGDR
- PTGER2
- PTGER4
- PTGIR
- PTH
- PTH1R
- PTH2
- PTH2R
- PTHLH
- RAMP1
- RAMP2
- RLF
- RXFP1
- RXFP2
- SCT
- SCTR
- TAAR1
- TAAR2
- TAAR3
- TAAR5
- TAAR9
- TGR5
- TSHB
- TSHR
- VIP
- VIPR1
- VIPR2
|
|
Collagen degradation
|
|
|
- COL12A1
- COL13A1
- COL18A1
- CTSB
- CTSD
- CTSK
- LOC112441463
- MMP11
- MMP12
- MMP13
- MMP14
- MMP15
- MMP2
- MMP20
- MMP3
- MMP7
- MMP8
- MMP9
- PHYKPL
- PRSS2
- TMPRSS6
|
|
Pentose phosphate pathway
|
|
|
- DERA
- G6PD
- PGD
- PGLS
- PGM2
- RBKS
- RPE
- RPIA
- SHPK
- TALDO1
- TKT
|
|
Degradation of the extracellular matrix
|
|
|
- ACAN
- ADAM10
- ADAM15
- ADAMTS4
- ADAMTS5
- BCAN
- BSG
- CAPN1
- CAPN10
- CAPN12
- CAPN13
- CAPN14
- CAPN2
- CAPN3
- CAPN4
- CAPN5
- CAPN6
- CAPN7
- CAPN8
- CAPNS1
- CAST
- CD44
- CDH1
- CTSK
- CTSL
- CTSL1
- CTSS
- DCN
- ELANE
- HTRA1
- KLK7
- LOC112441463
- LOC509956
- MADM
- MMP12
- MMP13
- MMP14
- MMP19
- MMP2
- MMP3
- MMP7
- MMP8
- MMP9
- NID1
- OPT
- OPTC
- SCUBE1
- SCUBE3
- SPP1
- TMPRSS6
|
|
Extra-nuclear estrogen signaling
|
|
|
- AREG
- BTC
- CALM
- CAV1
- CAV2
- EGFR
- EPGN
- EREG
- ESR
- ESR1
- ESR2
- GNAI1
- GNAI2
- GNAI3
- GNAT3
- GNB1
- GNB2
- GNB3
- GNB4
- GNB5
- GNG10
- GNG11
- GNG12
- GNG13
- GNG2
- GNG3
- GNG4
- GNG5
- GNG7
- GNG8
- GNGT1
- GNGT12
- GNGT2
- GNGT3
- GNGT5
- GNGT7
- GNGT8
- HBEGF
- HSP90A
- HSP90AA1
- HSPCA
- IGF1R
- MMP2
- MMP3
- MMP7
- MMP9
- NOS3
- NR3A1
- NR3A2
- PIK3CA
- PIK3R1
- PIK3R2
- PIK3R3
- PRMT1
- PTK2
- S1PR3
- SHC1
- SPHK1
- SRC
- STRN
- TGFA
- ZDHHC21
- ZDHHC7
|
|
Activation of Matrix Metalloproteinases
|
|
|
- COL18A1
- CTRB1
- CTSK
- CTSL
- CTSL1
- ELANE
- FURIN
- KLK1
- KLKB1
- KLNA1
- LOC100139881
- LOC112441463
- LOC112442231
- LOC509956
- LOC540321
- MMP11
- MMP13
- MMP14
- MMP15
- MMP16
- MMP17
- MMP2
- MMP24
- MMP25
- MMP3
- MMP7
- MMP8
- MMP9
- PLG
- PRSS2
- TIMP2
- TPSB1
|
|
EPH-ephrin mediated repulsion of cells
|
|
|
- APH1A
- APH1B
- EFNB1
- EFNB2
- EFNB3
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB6
- FYN
- LYN
- MMP2
- MMP9
- NCSTN
- PEN2
- PSEN1
- PSEN2
- PSENEN
- SRC
- VAV2
- VAV3
- YES1
|
|
O-glycosylation of TSR domain-containing proteins
|
|
|
- ADAMTS1
- ADAMTS10
- ADAMTS12
- ADAMTS13
- ADAMTS14
- ADAMTS15
- ADAMTS16
- ADAMTS17
- ADAMTS18
- ADAMTS19
- ADAMTS2
- ADAMTS20
- ADAMTS3
- ADAMTS4
- ADAMTS5
- ADAMTS6
- ADAMTS8
- ADAMTS9
- ADAMTSL1
- ADAMTSL3
- ADAMTSL4
- ADAMTSL5
- B3GLCT
- CFP
- NPI
- POFUT2
- RPESP
- SBSPON
- SEMA5A
- SEMA5B
- SPON1
- SSPO
- THBS1
- THBS2
- THSD1
- THSD7A
- THSD7B
- VSGP
|
|
Collagen biosynthesis and modifying enzymes
|
|
|
- ADAMTS14
- ADAMTS2
- ADAMTS3
- BMP1
- COL10A1
- COL11A1
- COL11A2
- COL12A1
- COL13A1
- COL14A1
- COL16A1
- COL17A1
- COL18A1
- COL1A1
- COL1A2
- COL20A1
- COL23A1
- COL26A1
- COL27A1
- COL28A1
- COL2A1
- COL3A1
- COL4A1
- COL4A3
- COL4A5
- COL4A6
- COL5A1
- COL5A3
- COL6A1
- COL6A2
- COL6A3
- COL6A5
- COL6A6
- COL8A1
- COL8A2
- COLGALT1
- COLGALT2
- GLT25D1
- LEPREL1
- NPI
- P3H2
- P3H3
- P4HA1
- P4HA2
- P4HA3
- P4HB
- PCOLCE
- PCOLCE2
- PLOD1
- PLOD2
- PLOD3
- SERPINH1
- TLL1
- TLL2
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