Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB) June 1, 2016
Species Pathogen Adherence Molecule Ligand Name Ligand Feature Target Source Glycan Sequence Binding PubMed ID
Botulinum neurotoxin (type C)
GD1b
Disialoglycosphingolipids
Presynaptic neuronal cells
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
Tetanus toxin
GD1b
Disialoglycosphingolipids
Brain membrane
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
BoNT/C (located within amino acid residues 1122-1290)
GD1b
Disialoglycosphingolipids
Presynaptic neuronal cells
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
Hemagglutinin (HA)
GD1a
Disialoglycosphingolipids
Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas)
NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
Unknown
GD1b
Disialoglycosphingolipids
Human brain
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
Unknown
GD1b
Disialoglycosphingolipids
Brain membrane
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
S-fimbriae (SfaA)
Seminolipid (Sulfogalactosylglycerolipid)
Glycolipids
Brain endothelial cells
Gal(3SO4)(b1-1)-alkylacylglycerol
Binding
S-fimbriae
Sialyl galactoside units of cell surface glycoproteins
Glycoproteins
Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles
NeuAc(a2-3)Gal(b1-4)Glc
Binding
Unknown
Sialylated type 2 chain conjugates (S-type 2-HSA)
Glycoproteins
Human serum albumin
NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
Binding
Unknown
Sialyl Lewis x (SLex-HSA)
Glycoproteins
Human serum albumin
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
Binding
Displaying entries 1 - 10 of 1840 in total

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01