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MIRAGE
Signaling by SCF-KIT

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
KitlgKitlgKitlgsSCF dimerKITKIT:sSCF dimerKIT:sSCF dimer:KITp-7Y-KIT:sSCF dimer:p-7Y-KITADPATPPI3K alphaPI3K:p-KIT:sSCF dimer:p-KITPIP2PIP3p-VAV1:PIP3Vav1GTPRac1-GTPRAC1:GDPGDPSFKs:p-KIT complexSFKs:p-8Y-KIT:sSCF dimer:p-8Y-KITGRB2:SOS1:p-KIT complexGRB2-1:SOS1PTPN11SHP2:SFKs:p-KIT:sSCF dimer:p-KITp-SHP2:p-KIT complexGRB2:p-SHP2:p-KIT complexGrb2GAB2:GRB2:p-SHP2:p-KIT complexGab2p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexPI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexp21 RAS:GDPp21 RAS:GTPTyrosine kinases:p-KIT complexTyrosine kinasesAdapter proteinsAdapter proteins:p-KIT complexJAK2JAK2:SFKS:p-KIT complexp-JAK2:SFKs:p-KIT complexp-JAK2:SFKs:p-KIT complex:STATsSTATsp-JAK2:SFKs:p-KIT complex:p-STATsp-JAK2:SFKs:p-KIT complex:p-STAT dimersp-STAT dimersPTPRU:KITPTPRUtype II KIT binding TKIsKIT:type II TKIsKIT:sSCF dimer:KIT:type I KIT binding TKIs:type I KIT binding TKIsKIT:ripretinibDCC2618
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025