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MIRAGE
Regulation of Complement cascade

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
C5AR2 ligandsC5AR2:C5AR2 ligandsC5ar2C5ar1C5AR1:C5aC5C3C3AR1:C3aC3ar1CFHR dimersCell surface:C3b:CFHR dimersCell surface:C3bQ9WUW3CFIQ9WUW3CR1:iC3bC3cCR1C3CR1:C4bC2aCell surface:C4b:C2aC3d, C3dg, iC3bCR2:C3d,C3dg,iC3bCr2CR2:C3d,C3dg,iC3b:CD19:CD81CD19:CD81CD46:Cell surface:C3bCd46CD46:Cell surface:C4bCell surface:C4bCFI:CD46, CR1:C4b, C3b complexesCD46, CR1:C4b:C3b complexesCD46, CR1C4c, C3fC4d, iC3bCD55:C4bC2aCd55C4bC4b with hydrolysed thioesterH2OAntigen:IgG:C1Q:2x Activated C1R:2x Activated C1SAntigen:IgG:C1Q:2xActivated C1R:2xActivated C1SQ6P734Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1Activated C1R:SERPING1Antigen:IgGActivated C1S:SERPING1C1QCLUCLU:C5b:C6:C7, C8, C9C9C5C5C5bTC3a, C5aC3a-desArg, C5a-desArg
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025