GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **51 - 75** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Phosphorylation of CD3 and TCR zeta chains	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3NYA3 A0A8I3P4A1 A0A8I3P4Z0 A0A8I3P564 A0A8I3P598 A0A8I3PAB8 A0A8I3PC26 A0A8I3PV90 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 CSK DLA-DQA1 DLA-DRA HLA-DQB2 LCK PAG1 PTPN22 PTPRC PTPRJ TRAV29DV5	Canis familiaris (dog)
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	A0A8I3MV46 A0A8I3Q5U6	ATAT1 HDAC6 MEC17	Canis familiaris (dog)
TNFR1-induced proapoptotic signaling	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP Inhibitor of nuclear factor kappa B kinase subunit epsilon RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Spermatogenesis associated 2 TANK binding kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD	A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3NEJ2 A0A8I3NK16 A0A8I3NS04 A0A8I3P2P4 A0A8I3PS24 A0A8I3Q155 A0A8I3Q3L1 A0A8I3S2L7 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CYLD IKBKE IRF9 MIB2 RBCK1 RIPK1 SPATA2 TBK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2 XIAP	Canis familiaris (dog)
MET interacts with TNS proteins	Hepatocyte growth factor receptor Hepatocyte growth factor Integrin beta Tensin 3 Tensin 4	A0A8I3MMP8 A0A8I3N5C8 A0A8I3NGY1 A0A8I3NIW4 Q867B7	HGF ITGB1 MET TNS3 TNS4	Canis familiaris (dog)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 CD40 ligand LIGHT Lymphotoxin beta receptor Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 13b Tumor necrosis factor (ligand) superfamily, member 12 Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 5	A0A8I3MDM0 A0A8I3MES0 A0A8I3MQC7 A0A8I3MWN3 A0A8I3NGJ3 A0A8I3NLQ1 A0A8I3NRP3 A0A8I3P6H0 A0A8I3PTD2 A0A8I3PZM4 A0A8I3RR83 A1E2V0 J9JHM5 J9P2Z1 J9P753 O97626 Q5WR07	BIRC2 BIRC3 CD40 CD40L CD40LG LTA LTB LTBR MAP3K14 TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF14 TNFSF5 TNLG1C TNLG1D TNLG7A TRAF2 TRAF3	Canis familiaris (dog)
EPHB-mediated forward signaling	Actin gamma 1 Actin, cytoplasmic 1 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 Arp2/3 complex 34 kDa subunit Cell division control protein 42 homolog Focal adhesion kinase 1 GTPase HRas Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Intersectin 1 RAS p21 protein activator 1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor 28 Rho-associated protein kinase 2 Rho-associated protein kinase TIAM Rac1 associated GEF 1 Transforming protein RhoA Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein WASP like actin nucleation promoting factor non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A8I3MEB5 A0A8I3ML64 A0A8I3MNR2 A0A8I3MPK0 A0A8I3MVD4 A0A8I3MXJ0 A0A8I3N156 A0A8I3N1W7 A0A8I3NE73 A0A8I3NEW9 A0A8I3NH46 A0A8I3NMF7 A0A8I3NMY1 A0A8I3P3X1 A0A8I3P9Q7 A0A8I3PDZ1 A0A8I3PGP9 A0A8I3PH24 A0A8I3PPA3 A0A8I3PPQ5 A0A8I3PUN0 A0A8I3PVV6 A0A8I3Q1I3 A0A8I3Q2I4 A0A8I3SAZ7 A0A8I3SBF9 F1PHV6 O18840 P60952 P62999 Q5R1P0 Q5R1P3	ACTB ACTG1 ACTR2 ACTR3 ARHGEF28 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 FYN GRIN1 GRIN2B HRAS KALRN LOC119867035 LYN NMDAR1 PAK1 PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SRC TIAM1 WASL YES1	Canis familiaris (dog)
TNFR1-induced NF-kappa-B signaling pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Optineurin RBR-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Small ribosomal subunit protein RACK1 Spermatogenesis associated 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Uncharacterized protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A8I3MA34 A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3N1V1 A0A8I3N4F2 A0A8I3N7L6 A0A8I3NEJ2 A0A8I3NMB6 A0A8I3NP69 A0A8I3P2P4 A0A8I3P499 A0A8I3P4Z1 A0A8I3PLL0 A0A8I3PS24 A0A8I3PWL6 A0A8I3Q3L1 A0A8I3RSQ2 A0A8I3RUY7 A0A8I3RZA9 A0A8I3S2L7 A0A8I3S792 A0A8I3S794 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CHUK CYLD IKBKB IKBKG IRF9 MAP3K7 OPTN OTUD1 OTUD7B RACK1 RBCK1 RIPK1 SPATA2 TAB1 TAB2 TAB3 TNF TNFA TNFAIP3 TNFRSF1A TNFSF2 TRADD TRAF2 USP2 USP21 USP4 XIAP	Canis familiaris (dog)
Translocation of ZAP-70 to Immunological synapse	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3P4A1 A0A8I3P564 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PC26 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA HLA-DQB2 LCK PTPN22 TRAV29DV5 ZAP70	Canis familiaris (dog)
Gamma-carboxylation of protein precursors	Coagulation factor IX Coagulation factor VII Coagulation factor X Osteocalcin Prothrombin Vitamin K-dependent gamma-carboxylase Vitamin K-dependent protein C Vitamin K-dependent protein S	A0A8I3N921 A0A8I3NHD9 A0A8I3PQV5 A0A8I3PUT1 A0A8I3QAV8 A0A8I3S489 A0A8I3SCE7 Q28278	BGLAP F10 F2 F7 F9 GGCX PROC PROS1	Canis familiaris (dog)
Voltage gated Potassium channels	Potassium voltage-gated channel modifier subfamily F member 1 Potassium voltage-gated channel modifier subfamily G member 1 Potassium voltage-gated channel modifier subfamily G member 3 Potassium voltage-gated channel modifier subfamily G member 4 Potassium voltage-gated channel modifier subfamily S member 2 Potassium voltage-gated channel modifier subfamily S member 3 Potassium voltage-gated channel modifier subfamily V member 2 Potassium voltage-gated channel subfamily A member 10 Potassium voltage-gated channel subfamily A member 1 Potassium voltage-gated channel subfamily A member 2 Potassium voltage-gated channel subfamily A member 4 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily A member 6 Potassium voltage-gated channel subfamily A member 7 Potassium voltage-gated channel subfamily A regulatory beta subunit 3 Potassium voltage-gated channel subfamily B member 1 Potassium voltage-gated channel subfamily B member 2 Potassium voltage-gated channel subfamily C member 1 Potassium voltage-gated channel subfamily C member 2 Potassium voltage-gated channel subfamily C member 3 Potassium voltage-gated channel subfamily C member 4 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3 Potassium voltage-gated channel subfamily H member 1 Potassium voltage-gated channel subfamily H member 2 Potassium voltage-gated channel subfamily H member 3 Potassium voltage-gated channel subfamily H member 4 Potassium voltage-gated channel subfamily H member 5 Potassium voltage-gated channel subfamily H member 6 Potassium voltage-gated channel subfamily H member 7 Potassium voltage-gated channel subfamily H member 8 Potassium voltage-gated channel subfamily Q member 4 Potassium voltage-gated channel subfamily Q member 5 Potassium voltage-gated channel subfamily S member 1 Potassium voltage-gated channel subfamily V member 1 Uncharacterized protein Voltage-gated potassium channel subunit beta-1 Voltage-gated potassium channel subunit beta-1	A0A8I3MEP9 A0A8I3MI33 A0A8I3MKX7 A0A8I3MLJ0 A0A8I3MVA0 A0A8I3MXL4 A0A8I3N7D5 A0A8I3NJP1 A0A8I3NJX7 A0A8I3NQD6 A0A8I3NTA2 A0A8I3NTD2 A0A8I3NX36 A0A8I3NXU7 A0A8I3P2T7 A0A8I3P439 A0A8I3PC38 A0A8I3PCB8 A0A8I3PHK5 A0A8I3PNB9 A0A8I3PQT7 A0A8I3PSN3 A0A8I3PT46 A0A8I3PV26 A0A8I3PWG2 A0A8I3PX68 A0A8I3PYY4 A0A8I3Q626 A0A8I3QAI0 A0A8I3RSP4 A0A8I3RV31 A0A8I3RXY5 A0A8I3S677 A0A8I3S7S4 A0A8I3SCN1 F1PBP9 F1PKN8 I0BWQ7 Q9TSZ3	CERG ERG KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2	Canis familiaris (dog)
MET Receptor Activation	HGF activator Hepatocyte growth factor receptor Hepatocyte growth factor Hepsin Serine peptidase inhibitor, Kunitz type 1 Serine peptidase inhibitor, Kunitz type 2	A0A8I3MSC1 A0A8I3MW78 A0A8I3NGY1 A0A8I3NIY8 A0A8I3S6Z5 Q867B7	HGF HGFAC HPN MET SPINT1 SPINT2	Canis familiaris (dog)
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Growth factor receptor bound protein 2 Kit ligand Mast/stem cell growth factor receptor Kit Protein kinase C SH2B adaptor protein 2 SH2B adaptor protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A8I3MBU4 A0A8I3ML64 A0A8I3MTK2 A0A8I3NAC6 A0A8I3P3X1 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PWC6 A0A8I3QRG3 A0A8I3S3D9 A0A8I3SBF9 O97799 Q06220	CBL FYN GRB2 KIT KITLG LCK LYN MGF PRKCA PTPN6 SH2B2 SH2B3 SOS1 SRC YES1	Canis familiaris (dog)
Terminal pathway of complement	Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9	A0A8I3MKJ7 A0A8I3MQ72 A0A8I3MRL7 A0A8I3NT81 A0A8I3NVC1 A0A8I3P0T6 A0A8I3RSI3 P25473	C5 C6 C7 C8A C8B C8G C9 CLU	Canis familiaris (dog)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Adapter molecule crk BCAR1 scaffold protein, Cas family member CRK like proto-oncogene, adaptor protein Cytoplasmic protein Cytoplasmic protein GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B RAS p21 protein activator 1 Rap guanine nucleotide exchange factor 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase small monomeric GTPase	A0A5F4C2B1 A0A8I3N1K5 A0A8I3N488 A0A8I3N971 A0A8I3N974 A0A8I3NAN8 A0A8I3NEF4 A0A8I3NGQ0 A0A8I3NID0 A0A8I3P5F5 A0A8I3PDZ1 A0A8I3PMT9 A0A8I3PN08 A0A8I3PSA1 A0A8I3PSP7 A0A8I3PT69 A0A8I3PWT3 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3RV66 A0A8I3RVE7 A0A8I3RXB9 A0A8I3S3D9 A0A8I3S3N2 A0A8I3S602 A0A8I3S8J3 A0A8I3SBF9 A0A8I3SCI7 Q6Q7I7	BCAR1 CRK CRKL GRB2 GRB7 HRAS KRAS NCK1 NCK2 NRAS PDGFA PDGFB PDGFRA PDGFRB PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PTPN11 RAPGEF1 RASA1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6	Canis familiaris (dog)
PI-3K cascade:FGFR3	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Multifunctional fusion protein Phosphatidylinositol 3-kinase regulatory subunit alpha Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0B4J199 A0A5F4C2B1 A0A7U3JWB8 A0A8I3MIK8 A0A8I3N971 A0A8I3NHF3 A0A8I3NS74 A0A8I3NTD6 A0A8I3NV07 A0A8I3NXI8 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3SAY5 J9P0B3 J9P3I7 J9P8K0 Q20FD0	FGF1 FGF16 FGF17 FGF18 FGF20 FGF23 FGF3A FGF4 FGF4B FGF4C FGF5 FGF7A FGF8 FGF8B FGF9 FGFR3 FRS2 GAB1 GRB2 PIK3CA PIK3R1 PTPN11	Canis familiaris (dog)
TNF signaling	ADAM metallopeptidase domain 17 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A8I3MQC7 A0A8I3NEJ2 A0A8I3PPY4 A0A8I3Q3L1 A0A8I3S2L7 P51742	ADAM17 RIPK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2	Canis familiaris (dog)
Aggrephagy	ADP ribosylation factor like GTPase 13B Centrin 1 Cystic fibrosis transmembrane conductance regulator Cystic fibrosis transmembrane conductance regulator Cytoplasmic dynein 1 intermediate chain 2 Dynein cytoplasmic 1 heavy chain 1 Dynein cytoplasmic 1 intermediate chain 1 Dynein light chain Dynein light chain Dynein light intermediate chain Dynein light intermediate chain E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase parkin Histone deacetylase 6 Intraflagellar transport 88 Pericentrin Ubiquitin B Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein protein deglycase	A0A8I3MGN8 A0A8I3MMN5 A0A8I3NFB9 A0A8I3NFH8 A0A8I3P2D4 A0A8I3P6I7 A0A8I3PAE0 A0A8I3PHA3 A0A8I3PVW4 A0A8I3PWV9 A0A8I3PX38 A0A8I3Q4C7 A0A8I3Q4T0 A0A8I3Q5U6 A0A8I3QYD0 A0A8I3RRP1 A0A8I3RSP2 A0A8I3RV68 A0A8I3S4X0 E2R2I5 P63050 Q5U820	ABCC7 ARL13B CETN1 CFTR DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HDAC6 IFT88 LOC119881719 PARK7 PCNT PRKN RPS27A UBA52 UBB UBC UBCEP2 UBE2N	Canis familiaris (dog)
ECM proteoglycans	Aggrecan core protein Agrin Biglycan Brevican core protein Cartilage oligomeric matrix protein Collagen type IX alpha 1 chain Collagen type IX alpha 2 Collagen type IX alpha 3 chain Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Fibronectin type-III domain-containing protein Hyaluronan and proteoglycan link protein 1 Integrin beta Integrin beta Integrin beta Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 2b Integrin subunit alpha 7 Integrin subunit alpha 8 Integrin subunit alpha 9 Integrin subunit alpha D Integrin subunit alpha V Matrilin 1 Matrilin 3 Matrilin 4 Neurocan Plasminogen activator inhibitor 1 SPARC Tenascin C Tenascin R Versican core protein Vitronectin	A0A8I3MC22 A0A8I3MDS4 A0A8I3MMP8 A0A8I3MS95 A0A8I3MWF4 A0A8I3N567 A0A8I3N600 A0A8I3N8Z0 A0A8I3NBB5 A0A8I3NFV4 A0A8I3NG24 A0A8I3NJU0 A0A8I3NL86 A0A8I3NUF9 A0A8I3P2A0 A0A8I3P4U9 A0A8I3P613 A0A8I3P787 A0A8I3P874 A0A8I3PAS0 A0A8I3PHY6 A0A8I3PLC3 A0A8I3PMU9 A0A8I3PZR7 A0A8I3QCJ7 A0A8I3RVA0 A0A8I3RVR5 A0A8I3RYZ7 A0A8I3S0I3 A0A8I3S0V6 A0A8I3S0V9 A0A8I3S700 E2DP67 Q29393	ACAN AGRN BCAN BGN COL9A1 COL9A2 COL9A3 COMP DCN DCN1C DMP1 DSPP HAPLN1 ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAD ITGAV ITGB1 ITGB3 ITGB5 ITGB6 MATN1 MATN3 MATN4 NCAN SEBOX SERPINE1 SPARC TNC TNR VCAN	Canis familiaris (dog)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A0A8I3PWD4 P01321	INS INSR	Canis familiaris (dog)
PI-3K cascade:FGFR2	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Multifunctional fusion protein Phosphatidylinositol 3-kinase regulatory subunit alpha Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0B4J199 A0A5F4C2B1 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3N971 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NXI8 A0A8I3NYK3 A0A8I3P4L9 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 FRS2 GAB1 GRB2 KGF PIK3CA PIK3R1 PTPN11	Canis familiaris (dog)
MET activates PTPN11	GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Tyrosine-protein phosphatase non-receptor type	A0A8I3NGY1 A0A8I3NXI8 A0A8I3PMT9 A0A8I3PT69 Q867B7	GAB1 GRB2 HGF MET PTPN11	Canis familiaris (dog)
FRS-mediated FGFR1 signaling	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NM39 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FRS2 FRS3 GRB2 HRAS KL KRAS NRAS PTPN11 SOS1	Canis familiaris (dog)
Adenosine P1 receptors	Adenosine receptor A1 Adenosine receptor A2a Adenosine receptor A3	P11616 P11617 Q28309	ADORA1 ADORA2A ADORA3 RDC7 RDC8	Canis familiaris (dog)
Insulin receptor recycling	ATPase H+ transporting V0 subunit b ATPase H+ transporting V1 subunit B1 ATPase H+ transporting V1 subunit E2 ATPase H+ transporting V1 subunit H ATPase H+ transporting accessory protein 1 Cathepsin D H(+)-transporting two-sector ATPase Insulin degrading enzyme Insulin Receptor-type tyrosine-protein phosphatase F Tyrosine-protein kinase receptor Tyrosine-protein phosphatase non-receptor type V-type proton ATPase proteolipid subunit V-type proton ATPase subunit C V-type proton ATPase subunit C V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit F V-type proton ATPase subunit G V-type proton ATPase subunit G V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit a V-type proton ATPase subunit V-type proton ATPase subunit V-type proton ATPase subunit Vacuolar proton pump subunit B	A0A8I3MGE7 A0A8I3MUZ6 A0A8I3MZT8 A0A8I3NAA2 A0A8I3NAS2 A0A8I3ND81 A0A8I3NF98 A0A8I3NSM9 A0A8I3NZA0 A0A8I3P989 A0A8I3PF77 A0A8I3PSZ6 A0A8I3PTB0 A0A8I3PWA9 A0A8I3PWD4 A0A8I3PXV2 A0A8I3PYI5 A0A8I3Q2N9 A0A8I3Q434 A0A8I3QBE3 A0A8I3QBV9 A0A8I3QKG1 A0A8I3QRA4 A0A8I3RRR2 A0A8I3RWI5 A0A8I3SB94 P01321 Q4LAL9	ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G3 ATP6V1H CTSD IDE INS INSR PTPN1 PTPRF TCIRG1	Canis familiaris (dog)
Digestion	Alkaline phosphatase Guanylate cyclase activator 2B Guanylate cyclase Guanylin Pirin	A0A8I3N4X7 A0A8I3P3W4 A0A8I3PB32 A0A8I3PK10 A0A8I3QK41	ALPI GUCA2A GUCA2B GUCY2C PIR	Canis familiaris (dog)

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