GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1276 - 1300** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism	GlyTouCan ID
RUNX1 regulates transcription of genes involved in BCR signaling	Core-binding factor subunit beta ETS-related transcription factor Elf-1 ETS-related transcription factor Elf-2 Paired box protein Pax-5 Runt-related transcription factor 1 Tyrosine-protein kinase Blk	P32519 P51451 Q01196 Q02548 Q13951 Q15723	AML1 BLK CBFA2 CBFB ELF1 ELF2 NERF PAX5 RUNX1	Homo sapiens (human)
RUNX1 regulates estrogen receptor mediated transcription	Axin-1 BTB/POZ domain-containing protein KCTD6 Core-binding factor subunit beta Estrogen receptor Glycerol-3-phosphate acyltransferase 1, mitochondrial Runt-related transcription factor 1	O15169 P03372 Q01196 Q13951 Q8NC69 Q9HCL2	AML1 AXIN AXIN1 CBFA2 CBFB ESR ESR1 GPAM GPAT1 KCTD6 KIAA1560 NR3A1 RUNX1	Homo sapiens (human)
RUNX1 regulates transcription of genes involved in WNT signaling	Axin-1 Core-binding factor subunit beta Estrogen receptor Forkhead box protein P3 R-spondin-3 Runt-related transcription factor 1	O15169 P03372 Q01196 Q13951 Q9BXY4 Q9BZS1	AML1 AXIN AXIN1 CBFA2 CBFB ESR ESR1 FOXP3 IPEX NR3A1 PWTSR RSPO3 RUNX1 THSD2	Homo sapiens (human)
RUNX1 regulates expression of components of tight junctions	Claudin-5 Core-binding factor subunit beta Occludin Runt-related transcription factor 1 Tight junction protein ZO-1	O00501 Q01196 Q07157 Q13951 Q16625	AML1 AWAL CBFA2 CBFB CLDN5 OCLN RUNX1 TJP1 TMVCF ZO1	Homo sapiens (human)
RUNX3 regulates p14-ARF	Bromodomain-containing protein 2 Core-binding factor subunit beta G1/S-specific cyclin-D1 GTPase KRas Histone acetyltransferase p300 Histone deacetylase 4 Runt-related transcription factor 1 Runt-related transcription factor 3 Transforming growth factor beta-1 proprotein	P01116 P01137 P24385 P25440 P56524 Q01196 Q09472 Q13761 Q13951	AML1 AML2 BCL1 BRD2 CBFA2 CBFA3 CBFB CCND1 EP300 HDAC4 KIAA0288 KIAA9001 KRAS KRAS2 P300 PEBP2A3 PRAD1 RASK2 RING3 RUNX1 RUNX3 TGFB TGFB1	Homo sapiens (human)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	26S proteasome regulatory subunit 4 Cytosolic endo-beta-N-acetylglucosaminidase Derlin-1 E3 ubiquitin-protein ligase AMFR Glucosidase 2 subunit beta Malectin Mannosyl-oligosaccharide glucosidase Neutral alpha-glucosidase AB Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 homolog B Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P14314 P54727 P55072 P62191 P62979 P62987 Q04323 Q13724 Q14165 Q14697 Q8NFI3 Q96IV0 Q9BUN8 Q9UKV5	AMFR DER1 DERL1 ENGASE G19P1 G2AN GANAB GCS1 HEL-220 HEL-S-70 KIAA0088 KIAA0152 MLEC MOGS NGLY1 PNG1 PRKCSH PSMC1 RAD23B RNF45 RPS27A SAKS1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBXN1 VCP	Homo sapiens (human)	G03934XO G25577BM G28233ME G51034LA G58161NS G86419OL
ER Quality Control Compartment (ERQC)	Derlin-2 E3 ubiquitin-protein ligase AMFR E3 ubiquitin-protein ligase MARCHF6 E3 ubiquitin-protein ligase RNF103 E3 ubiquitin-protein ligase RNF139 E3 ubiquitin-protein ligase RNF185 E3 ubiquitin-protein ligase RNF5 E3 ubiquitin-protein ligase TRIM13 E3 ubiquitin-protein ligase synoviolin ER degradation-enhancing alpha-mannosidase-like protein 1 ER degradation-enhancing alpha-mannosidase-like protein 2 ER degradation-enhancing alpha-mannosidase-like protein 3 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Polyubiquitin-B Polyubiquitin-C Protein OS-9 Protein sel-1 homolog 1 UDP-glucose UDP-glucose Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00237 O60337 O60858 P0CG47 P0CG48 P62979 P62987 Q13438 Q86TM6 Q8WU17 Q92611 Q96GF1 Q99942 Q9BV94 Q9BZQ6 Q9GZP9 Q9NYU1 Q9NYU2 Q9UBV2 Q9UKM7 Q9UKV5	AMFR C1orf22 C20orf31 C20orf49 DER2 DERL2 EDEM EDEM1 EDEM2 EDEM3 FLANA G16 GT HRD1 KIAA0212 KIAA0597 KIAA1810 LEU5 MAN1B1 MARCH6 MARCHF6 NG2 OS9 RFP2 RMA1 RNF103 RNF139 RNF176 RNF185 RNF45 RNF5 RNF77 RPS27A SEL1L SYVN1 TEB4 TRC8 TRIM13 TSA305 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UGCGL1 UGCGL2 UGGT UGGT1 UGGT2 UGT1 UGT2 UGTR ZFP103	Homo sapiens (human)	G70323CJ G93575MM
Truncations of AMER1 destabilize the destruction complex	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
APC truncation mutants have impaired AXIN binding	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
AXIN missense mutants destabilize the destruction complex	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
CTNNB1 S45 mutants aren't phosphorylated	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
CTNNB1 S37 mutants aren't phosphorylated	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
CTNNB1 S33 mutants aren't phosphorylated	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Signaling by GSK3beta mutants	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
CTNNB1 T41 mutants aren't phosphorylated	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Beta-catenin phosphorylation cascade	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 GSK-3-binding protein FRAT2 Glycogen synthase kinase-3 beta Proto-oncogene FRAT1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 O75474 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6 Q92837	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B FRAT1 FRAT2 GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Disassembly of the destruction complex and recruitment of AXIN to the membrane	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Casein kinase I isoform gamma-2 Catenin beta-1 Caveolin-1 Frizzled-1 Frizzled-2 Frizzled-5 GSK-3-binding protein FRAT2 Glycogen synthase kinase-3 beta Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Protein Wnt-3a Protein Wnt-8a Protein Wnt-8b Proto-oncogene FRAT1 Proto-oncogene Wnt-1 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O14640 O14641 O15169 O75197 O75474 O75581 P04628 P25054 P30153 P30154 P35222 P48729 P49841 P56704 P62714 P67775 P78368 Q03135 Q13362 Q13467 Q14332 Q14738 Q15172 Q15173 Q16537 Q5JTC6 Q92837 Q92997 Q93098 Q9H1J5 Q9UP38	AMER1 APC AXIN AXIN1 C2orf31 CAV CAV1 CK1G2 CSNK1A1 CSNK1G2 CTNNB CTNNB1 DP2.5 DVL1 DVL2 DVL3 FAM123B FRAT1 FRAT2 FZD1 FZD2 FZD5 GSK3B INT1 KIAA0044 KIAA0208 LR3 LRP5 LRP6 LRP7 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WNT1 WNT3A WNT8A WNT8B WNT8D WTX	Homo sapiens (human)
Histidine catabolism	Carnosine N-methyltransferase Carnosine synthase 1 Formimidoyltransferase-cyclodeaminase Histamine N-methyltransferase Histidine ammonia-lyase Histidine decarboxylase Probable imidazolonepropionase Urocanate hydratase	A5YM72 O95954 P19113 P42357 P50135 Q8N4J0 Q96N76 Q96NU7	AMDHD1 ATPGD1 C9orf41 CARNMT1 CARNS1 FTCD HAL HDC HIS HNMT KIAA1394 UROC1	Homo sapiens (human)
Metabolism of polyamines	Ornithine decarboxylase S-adenosylmethionine decarboxylase proenzyme Spermidine synthase Spermine synthase	P11926 P17707 P19623 P52788	AMD AMD1 ODC1 SMS SPS1 SRM SRML1	Homo sapiens (human)
Macroautophagy	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Activating molecule in BECN1-regulated autophagy protein 1 Autophagy protein 5 Autophagy-related protein 101 Autophagy-related protein 13 Autophagy-related protein 16-1 Autophagy-related protein 9A Autophagy-related protein 9B Beclin 1-associated autophagy-related key regulator Beclin-1 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cysteine protease ATG4A Cysteine protease ATG4B Cysteine protease ATG4C Cysteine protease ATG4D Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic GTP-binding protein Rheb Gamma-aminobutyric acid receptor-associated protein-like 1 Gamma-aminobutyric acid receptor-associated protein-like 2 Gamma-aminobutyric acid receptor-associated protein-like 3 Gamma-aminobutyric acid receptor-associated protein Hamartin Microtubule-associated proteins 1A/1B light chain 3A Microtubule-associated proteins 1A/1B light chain 3B Microtubule-associated proteins 1A/1B light chain 3C Neutral amino acid transporter 9 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 Phosphoinositide 3-kinase regulatory subunit 4 RB1-inducible coiled-coil protein 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase ULK1 Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8 Tuberin UV radiation resistance-associated gene protein Ubiquitin-like modifier-activating enzyme ATG7 Ubiquitin-like protein ATG12 Ubiquitin-like-conjugating enzyme ATG10 Ubiquitin-like-conjugating enzyme ATG3 WD repeat domain phosphoinositide-interacting protein 1 WD repeat domain phosphoinositide-interacting protein 2 WD repeat domain phosphoinositide-interacting protein 3 WD repeat domain phosphoinositide-interacting protein 4	O43504 O43633 O43741 O75143 O75385 O94817 O95166 O95352 P42345 P49815 P54619 P54646 P60520 P63167 Q0VGL1 Q13131 Q13615 Q14457 Q15382 Q5MNZ6 Q5MNZ9 Q5VZM2 Q674R7 Q676U5 Q6IAA8 Q6ZNE5 Q7L523 Q7Z3C6 Q86TL0 Q8N122 Q8NBW4 Q8NCE2 Q8NEB9 Q8TDY2 Q8WUX9 Q8WYN0 Q92574 Q96CF2 Q96DT6 Q96FJ2 Q96FZ7 Q99570 Q9BSB4 Q9BVC4 Q9BXW4 Q9BY43 Q9BY60 Q9C0C7 Q9GZQ8 Q9H0R8 Q9H0Y0 Q9H1Y0 Q9H444 Q9H492 Q9HB90 Q9NQL2 Q9NT62 Q9P2Y5 Q9UGI9 Q9UGJ0 Q9UHA4 Q9UQN3 Q9Y2Q5 Q9Y3E7 Q9Y478 Q9Y484 Q9Y4P1 Q9Y4P8	AMBRA1 AMPK AMPK1 AMPK2 AMPKG3 APG10L APG12 APG12L APG16L APG3 APG3L APG4A APG4B APG4C APG4D APG5L APG7L APG9L1 APG9L2 ASP ATG10 ATG101 ATG12 ATG13 ATG14 ATG14L ATG16L1 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATG9B AUTL1 AUTL2 AUTL3 AUTL4 BC2 BECN1 C11orf59 C12orf44 C14orf123 C20orf178 C3orf29 C7orf59 CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 DCAF3 DLC1 DLC2 DNCL1 DNCLC1 DYNLL1 DYNLL2 FLC3A FLC3B FRAP FRAP1 FRAP2 GABARAP GABARAPL1 GABARAPL2 GABARAPL3 GBL GEC1 GEF2 GT197 HBXIP HDLC1 KIAA0203 KIAA0243 KIAA0371 KIAA0652 KIAA0722 KIAA0831 KIAA0943 KIAA1303 KIAA1736 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP1ALC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTMR14 MTMR3 MTOR NEDF NOS3AS PDRO PIK3C3 PIK3R4 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAFT1 RAPT1 RAPTOR RB1CC1 RBICC RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SHAX1 SHAX2 SHAX3 SLC38A9 TSC TSC1 TSC2 TSC4 ULK1 URLC11 UVRAG VPS15 VPS20 VPS24 VPS34 WDR45 WDR45B WDR45L WDRX1 WDRXI4 WIPI1 WIPI2 WIPI3 WIPI4 WIPI49 XIP ZFYVE10	Homo sapiens (human)
mRNA 3'-end processing	ATP-dependent RNA helicase DDX39A Chromatin target of PRMT1 protein Cleavage and polyadenylation specificity factor subunit 1 Cleavage and polyadenylation specificity factor subunit 2 Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage and polyadenylation specificity factor subunit 7 Cleavage stimulation factor subunit 1 Cleavage stimulation factor subunit 2 tau variant Cleavage stimulation factor subunit 2 Cleavage stimulation factor subunit 3 Eukaryotic initiation factor 4A-III Leucine zipper protein 4 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Poly(A) polymerase alpha Polyadenylate-binding protein 2 Polymerase delta-interacting protein 3 Polyribonucleotide 5'-hydroxyl-kinase Clp1 Pre-mRNA 3'-end-processing factor FIP1 Pre-mRNA cleavage complex 2 protein Pcf11 Pre-mRNA-processing factor 17 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Pre-mRNA-splicing factor SLU7 Protein CASC3 Protein mago nashi homolog 2 Protein mago nashi homolog RNA-binding protein 8A RNA-binding protein with serine-rich domain 1 Regulator of nonsense transcripts 3B SAP domain-containing ribonucleoprotein Serine/arginine repetitive matrix protein 1 Serine/arginine-rich splicing factor 11 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 3 Serine/arginine-rich splicing factor 4 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Serine/arginine-rich splicing factor 9 Spliceosome RNA helicase DDX39B Splicing factor U2AF 26 kDa subunit Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Symplekin THO complex subunit 1 THO complex subunit 2 THO complex subunit 3 THO complex subunit 4 THO complex subunit 5 THO complex subunit 6 THO complex subunit 7 UAP56-interacting factor Zinc finger CCCH domain-containing protein 11A pre-mRNA 3' end processing protein WDR33	O00148 O15234 O43809 O60508 O75152 O94913 O95391 O95639 P26368 P33240 P38919 P51003 P52298 P61326 P82979 P84103 Q01081 Q01130 Q05048 Q05519 Q07955 Q08170 Q09161 Q10570 Q12996 Q13242 Q13243 Q13247 Q13769 Q13838 Q15287 Q16629 Q6I9Y2 Q6UN15 Q86U42 Q86V81 Q86W42 Q8IYB3 Q8N684 Q8NI27 Q8WU68 Q92620 Q92797 Q92989 Q96A72 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9BZI7 Q9C0J8 Q9H0L4 Q9P127 Q9P2I0 Q9UKF6 Q9Y3Y2 Q9Y5S9	ALY ALYREF ASF BAT1 BEF C1orf77 C22orf19 CASC3 CBP20 CBP80 CDC40 CFIM25 CHTOP CLP1 CPSF1 CPSF100 CPSF160 CPSF2 CPSF25 CPSF3 CPSF30 CPSF4 CPSF5 CPSF7 CPSF73 CSTF1 CSTF2 CSTF2T CSTF3 CXorf3 DDX38 DDX39 DDX39A DDX39B DDX48 DHX38 EHB3 EIF4A3 FIP1 FIP1L1 FOP FYTTD1 HCC1 HEAB HPR1 HRS KIAA0111 KIAA0224 KIAA0663 KIAA0689 KIAA0824 KIAA0983 KIAA1367 KIAA1649 LDC2 LUZP4 MAGOH MAGOH2 MAGOHA MAGOHB MLN51 NAR NCBP NCBP1 NCBP2 NEB1 NIF3L1BP1 NUDT21 PAB2 PABP2 PABPN1 PAP PAPOLA PCF11 PDIP46 POLDIP3 PRP16 PRP17 PRPF17 RBM8 RBM8A RENT3B RHE RNPS1 SARNP SF2 SF2P33 SFRS1 SFRS11 SFRS2 SFRS3 SFRS4 SFRS5 SFRS6 SFRS7 SFRS9 SLU7 SPK SRM160 SRP20 SRP30C SRP40 SRP55 SRP75 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SYMPK THOC1 THOC2 THOC3 THOC4 THOC5 THOC6 THOC7 U2AF1 U2AF1-RS3 U2AF1L3 U2AF1L4 U2AF2 U2AF35 U2AF65 U2AFBP UAP56 UIF UPF3B UPF3X WDC146 WDR33 WDR58 ZC3H11A ZC3HDC11A	Homo sapiens (human)
RNA Polymerase II Transcription Termination	ATP-dependent RNA helicase DDX39A Chromatin target of PRMT1 protein Cleavage and polyadenylation specificity factor subunit 1 Cleavage and polyadenylation specificity factor subunit 2 Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage and polyadenylation specificity factor subunit 7 Cleavage stimulation factor subunit 1 Cleavage stimulation factor subunit 2 tau variant Cleavage stimulation factor subunit 2 Cleavage stimulation factor subunit 3 Eukaryotic initiation factor 4A-III Histone RNA hairpin-binding protein Leucine zipper protein 4 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Poly(A) polymerase alpha Polyadenylate-binding protein 2 Polymerase delta-interacting protein 3 Polyribonucleotide 5'-hydroxyl-kinase Clp1 Pre-mRNA 3'-end-processing factor FIP1 Pre-mRNA cleavage complex 2 protein Pcf11 Pre-mRNA-processing factor 17 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Pre-mRNA-splicing factor SLU7 Protein CASC3 Protein mago nashi homolog 2 Protein mago nashi homolog RNA-binding protein 8A RNA-binding protein with serine-rich domain 1 Regulator of nonsense transcripts 3B SAP domain-containing ribonucleoprotein Serine/arginine repetitive matrix protein 1 Serine/arginine-rich splicing factor 11 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 3 Serine/arginine-rich splicing factor 4 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Serine/arginine-rich splicing factor 9 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated proteins B and B' Spliceosome RNA helicase DDX39B Splicing factor U2AF 26 kDa subunit Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Symplekin THO complex subunit 1 THO complex subunit 2 THO complex subunit 3 THO complex subunit 4 THO complex subunit 5 THO complex subunit 6 THO complex subunit 7 U7 snRNA-associated Sm-like protein LSm10 U7 snRNA-associated Sm-like protein LSm11 UAP56-interacting factor Zinc finger CCCH domain-containing protein 11A Zinc finger protein 473 pre-mRNA 3' end processing protein WDR33	O00148 O15234 O43809 O60508 O75152 O94913 O95391 O95639 P14678 P26368 P33240 P38919 P51003 P52298 P61326 P62304 P62306 P62308 P62318 P82979 P83369 P84103 Q01081 Q01130 Q05048 Q05519 Q07955 Q08170 Q09161 Q10570 Q12996 Q13242 Q13243 Q13247 Q13769 Q13838 Q14493 Q15287 Q16629 Q6I9Y2 Q6UN15 Q86U42 Q86V81 Q86W42 Q8IYB3 Q8N684 Q8NI27 Q8WTR7 Q8WU68 Q92620 Q92797 Q92989 Q969L4 Q96A72 Q96FV9 Q96J01 Q96QD9 Q9BY77 Q9BZI7 Q9C0J8 Q9H0L4 Q9P127 Q9P2I0 Q9UKF6 Q9Y3Y2 Q9Y5S9	ALY ALYREF ASF BAT1 BEF C1orf77 C22orf19 CASC3 CBP20 CBP80 CDC40 CFIM25 CHTOP CLP1 COD CPSF1 CPSF100 CPSF160 CPSF2 CPSF25 CPSF3 CPSF30 CPSF4 CPSF5 CPSF7 CPSF73 CSTF1 CSTF2 CSTF2T CSTF3 CXorf3 DDX38 DDX39 DDX39A DDX39B DDX48 DHX38 EHB3 EIF4A3 FIP1 FIP1L1 FOP FYTTD1 HBP HCC1 HEAB HPR1 HRS KIAA0111 KIAA0224 KIAA0663 KIAA0689 KIAA0824 KIAA0983 KIAA1141 KIAA1367 KIAA1649 LDC2 LSM10 LSM11 LUZP4 MAGOH MAGOH2 MAGOHA MAGOHB MLN51 NAR NCBP NCBP1 NCBP2 NEB1 NIF3L1BP1 NUDT21 PAB2 PABP2 PABPN1 PAP PAPOLA PBSCF PBSCG PCF11 PDIP46 POLDIP3 PRP16 PRP17 PRPF17 RBM8 RBM8A RENT3B RHE RNPS1 SARNP SF2 SF2P33 SFRS1 SFRS11 SFRS2 SFRS3 SFRS4 SFRS5 SFRS6 SFRS7 SFRS9 SLBP SLU7 SNRPB SNRPB1 SNRPD3 SNRPE SNRPF SNRPG SPK SRM160 SRP20 SRP30C SRP40 SRP55 SRP75 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SYMPK THOC1 THOC2 THOC3 THOC4 THOC5 THOC6 THOC7 U2AF1 U2AF1-RS3 U2AF1L3 U2AF1L4 U2AF2 U2AF35 U2AF65 U2AFBP UAP56 UIF UPF3B UPF3X WDC146 WDR33 WDR58 ZC3H11A ZC3HDC11A ZFP100 ZNF473	Homo sapiens (human)
RHOT2 GTPase cycle	Mitochondrial Rho GTPase 2 Mitofusin-1 Mitofusin-2 Rap1 GTPase-GDP dissociation stimulator 1 Trafficking kinesin-binding protein 1 Trafficking kinesin-binding protein 2 Unconventional myosin-XIX	O60296 O95140 P52306 Q8IWA4 Q8IXI1 Q96H55 Q9UPV9	ALS2CR3 ARHT2 C16orf39 CPRP1 KIAA0214 KIAA0549 KIAA1042 MFN1 MFN2 MYO19 MYOHD1 OIP106 RAP1GDS1 RHOT2 SMGGDS TRAK1 TRAK2	Homo sapiens (human)
RHOT1 GTPase cycle	Mitochondrial Rho GTPase 1 Rap1 GTPase-GDP dissociation stimulator 1 Trafficking kinesin-binding protein 1 Trafficking kinesin-binding protein 2 Unconventional myosin-XIX	O60296 P52306 Q8IXI2 Q96H55 Q9UPV9	ALS2CR3 ARHT1 KIAA0549 KIAA1042 MYO19 MYOHD1 OIP106 RAP1GDS1 RHOT1 SMGGDS TRAK1 TRAK2	Homo sapiens (human)
Energy dependent regulation of mTOR by LKB1-AMPK	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Calcium-binding protein 39-like Calcium-binding protein 39 GTP-binding protein Rheb Hamartin Neutral amino acid transporter 9 Protein phosphatase 1A Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR STE20-related kinase adapter protein alpha STE20-related kinase adapter protein beta Serine/threonine-protein kinase STK11 Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8 Tuberin	O43504 O43741 P35813 P42345 P49815 P54619 P54646 Q0VGL1 Q13131 Q15382 Q15831 Q5VZM2 Q6IAA8 Q7L523 Q7RTN6 Q8N122 Q8NBW4 Q92574 Q9BVC4 Q9C0K7 Q9H9S4 Q9HB90 Q9NQL2 Q9UGI9 Q9UGJ0 Q9UHA4 Q9Y2Q5 Q9Y376 Q9Y478	ALS2CR2 AMPK AMPK1 AMPK2 AMPKG3 C11orf59 C7orf59 CAB39 CAB39L FRAP FRAP1 FRAP2 GBL HBXIP ILPIP KIAA0243 KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LKB1 LST8 LYK5 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MO25 MTOR PDRO PJS PPM1A PPPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK11 STRAD STRADA STRADB TSC TSC1 TSC2 TSC4 URLC11 XIP	Homo sapiens (human)

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