metabolic dysfunction-associated steatotic liver disease

Summary
Synonym
  • MAFLD
  • MASLD
  • NAFLD
  • metabolic dysfunction-associated fatty liver disease
  • metabolic dysfunction-related steatotic liver disease
  • metabolic-associated fatty liver disease
  • non-alcoholic fatty liver disease
  • nonalcoholic fatty liver disease
Definition
A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are: (1) Body mass index ≥ 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents. (2) Fasting serum glucose ≥ 5.6 mmol/L, 2-hr post-load glucose levels ≥ 7.8 mmol/L, glycated hemoglobin (HbA1c) ≥ 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose ≥ 11.1 mmol/L (pediatric only). (3) Blood pressure ≥ lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age ≥ 13 years); or specific hypertensive drug treatment. (4) Plasma triglycerides ≥ 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age ≥ 10 years); or lipid lowering treatment. (5) Plasma high-density lipoprotein cholesterol ≤ 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment.
Super Class
steatotic liver disease
Disease Ontology
DOID:0080208
Mondo Disease Ontology
MeSH
OMIM
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 71 - 80 of 88 in total
Gene ID Gene Symbol Description Source
23417 MLYCD malonyl-CoA decarboxylase
25813 SAMM50 SAMM50 sorting and assembly machinery component
51085 MLXIPL MLX interacting protein like
51092 SIDT2 SID1 transmembrane family member 2
51548 SIRT6 sirtuin 6
54106 TLR9 toll like receptor 9
57678 GPAM glycerol-3-phosphate acyltransferase, mitochondrial
64240 ABCG5 ATP binding cassette subfamily G member 5
64241 ABCG8 ATP binding cassette subfamily G member 8
79068 FTO FTO alpha-ketoglutarate dependent dioxygenase
Displaying entries 1 - 10 of 80 in total
Gene ID Gene Symbol Description Source
11364 Acadm acyl-Coenzyme A dehydrogenase, medium chain
11370 Acadvl acyl-Coenzyme A dehydrogenase, very long chain
11450 Adipoq adiponectin, C1Q and collagen domain containing
11461 Actb actin, beta
11520 Plin2 perilipin 2
11556 Adrb3 adrenergic receptor, beta 3
11615 Ahcyl adenosylhomocysteinase like
11651 Akt1 thymoma viral proto-oncogene 1
11669 Aldh2 aldehyde dehydrogenase 2, mitochondrial
11946 Atp5f1a ATP synthase F1 subunit alpha
Displaying entries 21 - 30 of 45 in total
Gene ID Gene Symbol Description Source
29260 Tlr4 toll-like receptor 4
29393 Col1a1 collagen type I alpha 1 chain
29485 Slc7a3 solute carrier family 7 member 3
29539 Aldh2 aldehyde dehydrogenase 2 family member
50671 Fasn fatty acid synthase
54315 Ucp2 uncoupling protein 2
60582 Il1rn interleukin 1 receptor antagonist
64678 Tfrc transferrin receptor
65262 Atp5f1a ATP synthase F1 subunit alpha
81822 Actb actin, beta
Displaying entry 11 - 11 of 11 in total
Gene ID Gene Symbol Description Source
43222 Tl Toll
Displaying all 4 entries
Gene ID Gene Symbol Description Source
406207 mttp microsomal triglyceride transfer protein
447803 pon1 paraoxonase 1
565316 dgat2 diacylglycerol O-acyltransferase 2
768121 foxo1a forkhead box O1 a
Displaying all 4 entries
Gene ID Gene Symbol Description Source Organism
395003 dgat2 diacylglycerol O-acyltransferase 2 Xenopus tropicalis (tropical clawed frog)
398800 dgat2.L diacylglycerol O-acyltransferase 2 L homeolog Xenopus laevis (African clawed frog)
399170 akt1.S AKT serine/threonine kinase 1 S homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
Displaying entries 1 - 10 of 13 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
175410 daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
176852 dsc-4 Microsomal triglyceride transfer protein homolog
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
178046 gspd-1 Glucose-6-phosphate 1-dehydrogenase
178215 pgp-1 Multidrug resistance protein pgp-1
178672 srp-3 Serpin domain-containing protein
180289 mrp-7 Multidrug resistance protein mrp-7
180408 mrp-2 Multidrug resistance-associated protein 1
180409 mrp-1 Multidrug resistance-associated protein 1
Displaying entries 1 - 10 of 14 in total
Gene ID Gene Symbol Description Source
851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
851193 CDC19 pyruvate kinase CDC19
852803 HNM1 Hnm1p
853590 VPS70 putative zinc metalloprotease
853671 STE6 ATP-binding cassette a-factor transporter STE6
854080 YOL075C uncharacterized protein
854419 DGA1 diacylglycerol O-acyltransferase
854430 TRE2 putative zinc metalloprotease
854529 PYK2 pyruvate kinase PYK2
854900 HMG1 hydroxymethylglutaryl-CoA reductase (NADPH) HMG1

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