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MIRAGE
metabolic dysfunction-associated steatotic liver disease
Summary
- Synonym
-
- MAFLD
- MASLD
- NAFLD
- metabolic dysfunction-associated fatty liver disease
- metabolic dysfunction-related steatotic liver disease
- metabolic-associated fatty liver disease
- non-alcoholic fatty liver disease
- nonalcoholic fatty liver disease
- Definition
- A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
- Super Class
- steatotic liver disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 10891 | PPARGC1A | PPARG coactivator 1 alpha | |
| 25813 | SAMM50 | SAMM50 sorting and assembly machinery component | |
| 80339 | PNPLA3 | patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase | |
| 84649 | DGAT2 | diacylglycerol O-acyltransferase 2 | |
| 729230 | CCR2 | C-C motif chemokine receptor 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24539 | Lpl | lipoprotein lipase | |
| 29393 | Col1a1 | collagen type I alpha 1 chain | |
| 54315 | Ucp2 | uncoupling protein 2 | |
| 65262 | Atp5f1a | ATP synthase F1 subunit alpha | |
| 81822 | Actb | actin, beta | |
| 83516 | Ppargc1a | PPARG coactivator 1 alpha | |
| 83619 | Nfe2l2 | NFE2 like bZIP transcription factor 2 |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01266 | Thyroglobulin | |
| P04179 | Superoxide dismutase [Mn], mitochondrial | |
| P05091 | Aldehyde dehydrogenase, mitochondrial | |
| P05231 | Interleukin-6 | |
| P13945 | Beta-3 adrenergic receptor | |
| P31749 | RAC-alpha serine/threonine-protein kinase | |
| P41597 | C-C chemokine receptor type 2 | |
| P48357 | Leptin receptor | |
| Q15848 | Adiponectin | |
| Q30201 | Hereditary hemochromatosis protein |
| UniProt ID | Protein Name | Source |
|---|---|---|
| Q640Q2 | Lepr protein | |
| Q8CIF6 | SID1 transmembrane family member 2 | |
| Q91WW7 | 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O54968 | Nuclear factor erythroid 2-related factor 2 | |
| P02454 | Collagen alpha-1(I) chain | |
| P15127 | Insulin receptor | |
| P15999 | ATP synthase subunit alpha, mitochondrial | |
| P60711 | Actin, cytoplasmic 1 | |
| Q06000 | Lipoprotein lipase | |
| Q9QYK2 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha |
