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Standards Ontologies Notations
Alzheimer's disease

Summary
Synonym
  • Alzheimer disease
  • Alzheimers dementia
Definition
A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Super Class
tauopathy
Disease Ontology
DOID:10652
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entry 291 - 291 of 291 in total
Gene ID Gene Symbol Description Source
119391 GSTO2 glutathione S-transferase omega 2
Displaying entries 31 - 40 of 240 in total
Gene ID Gene Symbol Description Source
11977 Atp7a ATPase, copper transporting, alpha polypeptide
12015 Bad BCL2-associated agonist of cell death
12028 Bax BCL2-associated X protein
12038 Bche butyrylcholinesterase
12064 Bdnf brain derived neurotrophic factor
12260 C1qb complement component 1, q subcomponent, beta polypeptide
12263 C2 complement C2
12266 C3 complement component 3
12273 C5ar1 complement component 5a receptor 1
12322 Camk2a calcium/calmodulin-dependent protein kinase II alpha
Displaying entries 1 - 10 of 158 in total
Gene ID Gene Symbol Description Source
24153 A2m alpha-2-macroglobulin
24179 Agt angiotensinogen
24180 Agtr1a angiotensin II receptor, type 1a
24225 Bdnf brain-derived neurotrophic factor
24232 C3 complement C3
24253 Cebpb CCAAT/enhancer binding protein beta
24255 Cftr CF transmembrane conductance regulator
24310 Ace angiotensin I converting enzyme
24318 Drd2 dopamine receptor D2
24333 Eno1 enolase 1
Displaying entries 1 - 10 of 49 in total
Gene ID Gene Symbol Description Source
31002 Appl beta amyloid protein precursor-like
31248 sgg shaggy
31293 N Notch
31364 Fas2 Fasciclin 2
31547 Nep1 Neprilysin 1
31792 Nrg Neuroglian
32342 amrt amaretto
32545 Gapdh2 Glyceraldehyde 3 phosphate dehydrogenase 2
33005 Nep3 Neprilysin 3
33007 Dop2R Dopamine 2-like receptor
Displaying entries 1 - 10 of 19 in total
Gene ID Gene Symbol Description Source
30262 ins preproinsulin
30682 vegfaa vascular endothelial growth factor Aa
30705 fgfr1a fibroblast growth factor receptor 1a
30718 notch1a notch receptor 1a
58133 ngfb nerve growth factor b (beta polypeptide)
114549 ache acetylcholinesterase (Yt blood group)
317743 gapdh glyceraldehyde-3-phosphate dehydrogenase
394082 slc18a3b solute carrier family 18 member 3b
406367 gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
436913 tm2d2 TM2 domain containing 2
Displaying entries 1 - 10 of 37 in total
Gene ID Gene Symbol Description Source Organism
373644 ldlr.S low density lipoprotein receptor S homeolog Xenopus laevis (African clawed frog)
378584 drd2.L dopamine receptor D2 L homeolog Xenopus laevis (African clawed frog)
378605 htr1a.L 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog Xenopus laevis (African clawed frog)
380259 gapdh.S glyceraldehyde-3-phosphate dehydrogenase S homeolog Xenopus laevis (African clawed frog)
380298 eno1.S enolase 1 S homeolog Xenopus laevis (African clawed frog)
380307 bace2.L beta-secretase 2 L homeolog Xenopus laevis (African clawed frog)
380341 pon2.L paraoxonase 2 L homeolog Xenopus laevis (African clawed frog)
397713 psen2.S presenilin 2 S homeolog Xenopus laevis (African clawed frog)
397750 hmgcr.L 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog Xenopus laevis (African clawed frog)
397757 ldlr.L low density lipoprotein receptor L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 56 in total
Gene ID Gene Symbol Description Source
171782 abt-2 ABC transporter domain-containing protein
171905 ace-2 Carboxylic ester hydrolase
171999 poml-2 Arylesterase
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
172689 sup-17 Disintegrin and metalloproteinase domain-containing protein 10 homolog
172703 unc-29 Acetylcholine receptor subunit beta-type unc-29
172905 aph-2 Nicastrin
173685 nep-11 Neprilysin-11
173794 vab-1 Ephrin receptor 1
Displaying entries 1 - 10 of 25 in total
Gene ID Gene Symbol Description Source
850812 YPS3 aspartyl protease
851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
851950 YPS7 putative aspartic endopeptidase
852264 PEP1 type I sorting receptor
852543 VVS1 Vvs1p
852702 XRN1 chromatin-binding exonuclease XRN1
852806 HSF1 stress-responsive transcription factor HSF1
853106 TDH3 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3
853169 ENO1 phosphopyruvate hydratase ENO1
853233 VTH2 signal sequence-binding protein
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Acknowledgements

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Last updated: December 9, 2024