major depressive disorder

Summary
Synonym
  • clinical depression
  • major depression
  • recurrent major depression
  • single major depressive episode
  • unipolar depression
Definition
A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Super Class
depressive disorder
Disease Ontology
DOID:1470
Mondo Disease Ontology
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 11 - 20 of 32 in total
Gene ID Gene Symbol Description Source
3084 NRG1 neuregulin 1
3303 HSPA1A heat shock protein family A (Hsp70) member 1A
3305 HSPA1L heat shock protein family A (Hsp70) member 1 like
3351 HTR1B 5-hydroxytryptamine receptor 1B
3356 HTR2A 5-hydroxytryptamine receptor 2A
3358 HTR2C 5-hydroxytryptamine receptor 2C
3562 IL3 interleukin 3
3567 IL5 interleukin 5
3569 IL6 interleukin 6
3586 IL10 interleukin 10
Displaying entries 1 - 10 of 23 in total
Gene ID Gene Symbol Description Source
12064 Bdnf brain derived neurotrophic factor
14815 Nr3c1 nuclear receptor subfamily 3, group C, member 1
15482 Hspa1l heat shock protein 1-like
15551 Htr1b 5-hydroxytryptamine (serotonin) receptor 1B
15558 Htr2a 5-hydroxytryptamine (serotonin) receptor 2A
15560 Htr2c 5-hydroxytryptamine (serotonin) receptor 2C
15567 Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
16153 Il10 interleukin 10
16187 Il3 interleukin 3
16191 Il5 interleukin 5
Displaying entries 11 - 14 of 14 in total
Gene ID Gene Symbol Description Source
81645 Chrm2 cholinergic receptor, muscarinic 2
85426 Slc5a7 solute carrier family 5 member 7
171131 Chrnb3 cholinergic receptor nicotinic beta 3 subunit
286963 Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5
Displaying entry 11 - 11 of 11 in total
Gene ID Gene Symbol Description Source
42920 nAChRbeta2 nicotinic Acetylcholine Receptor beta2
Displaying all 6 entries
Gene ID Gene Symbol Description Source
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
178167 nlr-1 Neurexin like receptor 1
178274 cho-1 High-affinity choline transporter 1
179962 gar-3 Muscarinic acetylcholine receptor gar-3
180937 acr-3 Acetylcholine receptor subunit beta-type acr-3
Displaying 1 entry
Gene ID Gene Symbol Description Source
850442 SRB8 Srb8p

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Last updated: December 9, 2024