chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 51 - 60 of 126 in total
Gene ID Gene Symbol Description Source
3066 HDAC2 histone deacetylase 2
3115 HLA-DPB1 major histocompatibility complex, class II, DP beta 1
3240 HP haptoglobin
3308 HSPA4 heat shock protein family A (Hsp70) member 4
3356 HTR2A 5-hydroxytryptamine receptor 2A
3383 ICAM1 intercellular adhesion molecule 1
3557 IL1RN interleukin 1 receptor antagonist
3567 IL5 interleukin 5
3568 IL5RA interleukin 5 receptor subunit alpha
3569 IL6 interleukin 6
Displaying entries 1 - 10 of 123 in total
Gene ID Gene Symbol Description Source
11421 Ace angiotensin I converting enzyme
11441 Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7
11450 Adipoq adiponectin, C1Q and collagen domain containing
11502 Adam9 ADAM metallopeptidase domain 9
11554 Adrb1 adrenergic receptor, beta 1
11555 Adrb2 adrenergic receptor, beta 2
11596 Ager advanced glycosylation end product-specific receptor
12062 Bdkrb2 bradykinin receptor, beta 2
12176 Bnip3 BCL2/adenovirus E1B interacting protein 3
12266 C3 complement component 3
Displaying entries 61 - 68 of 68 in total
Gene ID Gene Symbol Description Source
116630 Csf2 colony stimulating factor 2
116677 F2rl1 F2R like trypsin receptor 1
117029 Ccr5 C-C motif chemokine receptor 5
156767 Tnfrsf1b TNF receptor superfamily member 1B
192155 Sftpb surfactant protein B
246097 Fas Fas cell surface death receptor
246274 Faim2 Fas apoptotic inhibitory molecule 2
287561 Ccl7 C-C motif chemokine ligand 7
Displaying entries 1 - 10 of 21 in total
Gene ID Gene Symbol Description Source
31926 Idgf4 Imaginal disc growth factor 4
34091 Spn28Dc Serpin 28Dc
34189 Acer Angiotensin-converting enzyme-related
34304 nAChRalpha6 nicotinic Acetylcholine Receptor alpha6
34805 Ance Angiotensin converting enzyme
34978 Idgf1 Imaginal disc growth factor 1
34979 Idgf2 Imaginal disc growth factor 2
34981 Idgf3 Imaginal disc growth factor 3
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 31 - 33 of 33 in total
Gene ID Gene Symbol Description Source
188252 lev-9 Protein lev-9
191484 pxn-1 Peroxidasin homolog pxn-1
191602 acr-15 Acetylcholine receptor subunit alpha-type acr-15
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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