chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 1 - 10 of 126 in total
Gene ID Gene Symbol Description Source
12 SERPINA3 serpin family A member 3
153 ADRB1 adrenoceptor beta 1
154 ADRB2 adrenoceptor beta 2
177 AGER advanced glycosylation end-product specific receptor
355 FAS Fas cell surface death receptor
356 FASLG Fas ligand
624 BDKRB2 bradykinin receptor B2
718 C3 complement C3
727 C5 complement C5
728 C5AR1 complement C5a receptor 1
Displaying entries 91 - 100 of 123 in total
Gene ID Gene Symbol Description Source
20657 Sod3 superoxide dismutase 3, extracellular
20700 Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A
20701 Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B
20702 Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C
20703 Serpina1d serine (or cysteine) peptidase inhibitor, clade A, member 1D
20704 Serpina1e serine (or cysteine) peptidase inhibitor, clade A, member 1E
20714 Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K
20716 Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N
20717 Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M
21803 Tgfb1 transforming growth factor, beta 1
Displaying entries 11 - 20 of 68 in total
Gene ID Gene Symbol Description Source
24565 Abcc1 ATP binding cassette subfamily C member 1
24598 Nos1 nitric oxide synthase 1
24617 Serpine1 serpin family E member 1
24648 Serpina1 serpin family A member 1
24770 Ccl2 C-C motif chemokine ligand 2
24773 Sftpa1 surfactant protein A1
24794 Serpina3c serine (or cysteine) proteinase inhibitor, clade A, member 3C
24795 Serpina3n serpin family A member 3N
24835 Tnf tumor necrosis factor
24925 Adrb1 adrenoceptor beta 1
Displaying entry 21 - 21 of 21 in total
Gene ID Gene Symbol Description Source
43222 Tl Toll
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 33 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
172449 glr-3 Glutamate receptor ionotropic, kainate glr-3
174262 acr-7 Acetylcholine receptor subunit alpha-type acr-7
174462 let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
175072 eat-2 Neuronal acetylcholine receptor subunit eat-2
175182 ver-1 Protein ver-1
175383 zmp-2 Matrix metalloproteinase-B
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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