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myelofibrosis
Summary
- Synonym
-
- Agnogenic myeloid metaplasia
- Aleukemic myelosis
- Megakaryocytic myelosclerosis
- bone Marrow Fibrosis
- myelosclerosis
- primary myelofibrosis
- Definition
- A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
- Super Class
- myeloid neoplasm
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2539 | G6PD | glucose-6-phosphate dehydrogenase | |
| 3417 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 | |
| 3418 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 | |
| 3939 | LDHA | lactate dehydrogenase A | |
| 3945 | LDHB | lactate dehydrogenase B | |
| 3956 | LGALS1 | galectin 1 | |
| 3958 | LGALS3 | galectin 3 | |
| 4680 | CEACAM6 | CEA cell adhesion molecule 6 | |
| 5290 | PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | |
| 5291 | PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P42338 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |
| P48735 | Isocitrate dehydrogenase [NADP], mitochondrial | |
| P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | |
| Q13231 | Chitotriosidase-1 | |
| Q13478 | Interleukin-18 receptor 1 | |
| Q5H8C1 | FRAS1-related extracellular matrix protein 1 | |
| Q8N6Q3 | CD177 antigen |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001876 | Pancytopenia |
| HP:0012378 | Fatigue |
| HP:0001945 | Fever |
| HP:0001433 | Hepatosplenomegaly |
| HP:0004326 | Cachexia |
| HP:0000967 | Petechiae |
| HP:0001974 | Leukocytosis |
| HP:0004377 | Hematological neoplasm |
| HP:0001744 | Splenomegaly |
| HP:0005561 | Abnormal bone marrow cell morphology |
