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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
obesity
Summary
- Definition
- An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
- Super Class
- overnutrition
External Links
- Disease Ontology
- DOID:9970
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
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- 3766125
- 3821619
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- 3817475
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- 5515728
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- 6273993
- 5828524
- 5766495
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- 3655832
- 5447549
- 5300906
- 3850836
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- 3840234
- 3832410
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- 3033164
- 3511746
- 3055585
- 3055584
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- 3036853
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- 3033165
- 3511747
- 2681522
- 2680503
- 2669229
- 2663736
- 2654708
- 2653295
- 2651886
- 2388265
- 3589409
- 3655811
- 3639781
- 3639355
- 3639354
- 3629805
- 3623749
- 3620067
- 3611807
- 2174793
- 3586756
- 3582615
- 3580003
- 3579026
- 3577766
- 3526863
- 3511748
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 1312 | COMT | catechol-O-methyltransferase | |
| 1374 | CPT1A | carnitine palmitoyltransferase 1A | |
| 1376 | CPT2 | carnitine palmitoyltransferase 2 | |
| 1431 | CS | citrate synthase | |
| 1543 | CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | |
| 1544 | CYP1A2 | cytochrome P450 family 1 subfamily A member 2 | |
| 1545 | CYP1B1 | cytochrome P450 family 1 subfamily B member 1 | |
| 1555 | CYP2B6 | cytochrome P450 family 2 subfamily B member 6 | |
| 1559 | CYP2C9 | cytochrome P450 family 2 subfamily C member 9 | |
| 1571 | CYP2E1 | cytochrome P450 family 2 subfamily E member 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11652 | Akt2 | thymoma viral proto-oncogene 2 | |
| 11668 | Aldh1a1 | aldehyde dehydrogenase family 1, subfamily A1 | |
| 11815 | Apod | apolipoprotein D | |
| 12015 | Bad | BCL2-associated agonist of cell death | |
| 12846 | Comt | catechol-O-methyltransferase | |
| 12894 | Cpt1a | carnitine palmitoyltransferase 1a, liver | |
| 14380 | G6pd2 | glucose-6-phosphate dehydrogenase 2 | |
| 14381 | G6pdx | glucose-6-phosphate dehydrogenase X-linked | |
| 14433 | Gapdh | glyceraldehyde-3-phosphate dehydrogenase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24267 | Comt | catechol-O-methyltransferase | |
| 24377 | G6pd | glucose-6-phosphate dehydrogenase | |
| 24383 | Gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 24385 | Gck | glucokinase | |
| 24536 | Lepr | leptin receptor | |
| 24577 | Myc | MYC proto-oncogene, bHLH transcription factor | |
| 24835 | Tnf | tumor necrosis factor | |
| 25058 | Hk1 | hexokinase 1 | |
| 25059 | Hk2 | hexokinase 2 | |
| 25233 | Akt2 | AKT serine/threonine kinase 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850614 | HXK1 | hexokinase 1 | |
| 851974 | YPR1 | trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 | |
| 852128 | EMI2 | putative glucokinase | |
| 852639 | HXK2 | hexokinase 2 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853395 | TDH1 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 | |
| 853465 | TDH2 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 | |
| 854287 | GCY1 | glycerol 2-dehydrogenase (NADP(+)) GCY1 | |
| 855480 | ZWF1 | glucose-6-phosphate dehydrogenase |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P07741 | Adenine phosphoribosyltransferase | |
| P08571 | Monocyte differentiation antigen CD14 | |
| P08842 | Steryl-sulfatase | |
| P09104 | Gamma-enolase | |
| P09326 | CD48 antigen | |
| P09382 | Galectin-1 | |
| P09848 | Lactase/phlorizin hydrolase | |
| P09874 | Poly [ADP-ribose] polymerase 1 | |
| P10645 | Chromogranin-A | |
| P11150 | Hepatic triacylglycerol lipase |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001513 | Obesity |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0010982 | Polygenic inheritance |
| HP:0012340 | Decreased resting energy expenditure |
