GlyCosmos Portal

Submissions

beta galactoside alpha 2,6 sialyltransferase 1

Summary

Gene Symbol

St6gal1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20440

KEGG Gene ID

mmu:20440

PubChem

20440

Alliance of Genome Resources

MGI:108470

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BM62
Q64685	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 ST6Gal I Sialyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein N-linked glycosylation via asparagine	IBA IDA ISO	22039275
negative regulation of chemotaxis	ISO
negative regulation of macrophage apoptotic process	ISO
N-acetylneuraminate metabolic process	ISO
positive regulation of mononuclear cell proliferation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

sialylation

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of leukocyte apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
Golgi medial cisterna	ISO
extracellular region	IEA
membrane	IEA
Golgi apparatus	IBA
Golgi trans cisterna	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
beta-galactoside alpha-2,6-sialyltransferase activity	IBA IDA IMP ISO	12068010 22039275
transferase activity	IEA
protein homodimerization activity	ISO
sialyltransferase activity	IDA ISO	12966079

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00778

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]

References

2408023

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05990	2.4.3.1	G78059CC	G56749GV

Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37950	FB:FBgn0035050
Callorhinchus milii	103174913		CALMI01037
Danio rerio	445376	ZFIN:ZDB-GENE-060322-3
Astyanax mexicanus	103030360		ASTMX07964
Electrophorus electricus	113576168		ELEEL17685
Xenopus tropicalis	100491268	Xenbase:XB-GENE-983202
Pseudonaja textilis	113436829		PSETE07837
Anas platyrhynchos platyrhynchos	101803267		ANAPP26083
Serinus canaria	103815542		SERCA09322
Ornithorhynchus anatinus	100093341		ORNAN11063