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Multi drug resistance 65

Summary

Gene Symbol

Mdr65

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

38726

PubChem

38726

Alliance of Genome Resources

FB:FBgn0004513

Annotation

Keyword

ATP-binding
Glycoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00748	P-glycoprotein 65

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEP	19545574
response to insecticide	IMP	29056374
xenobiotic transport	IDA	19295159
transmembrane transport	IBA
transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

transmembrane transport

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal tubular secretion

excretion [inference]

renal tubular secretion

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

response to insecticide

localization [inference]

establishment of localization [inference]

transport [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
pleated septate junction	IDA	19295159
membrane	IBA
membrane	IEA
ATP-binding cassette (ABC) transporter complex	IDA	19295159

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

septate junction [inference]

pleated septate junction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
ABC-type xenobiotic transporter activity	IDA	19295159
efflux transmembrane transporter activity	IDA	19295159
ATP hydrolysis activity	IEA
ATPase-coupled transmembrane transporter activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
membrane	FB:FBrf0231198
ATP-binding cassette (ABC) transporter complex	PMID:19295159
pleated septate junction	PMID:19295159

Ortholog

Displaying entries **1 - 10** of 16 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	5243	ZFIN:ZDB-GENE-080204-52
Danio rerio	5244	ZFIN:ZDB-GENE-080204-52
Saccharomyces cerevisiae S288C	8647	SGD:S000001692
Danio rerio	18669	ZFIN:ZDB-GENE-080204-52
Danio rerio	18670	ZFIN:ZDB-GENE-080204-52
Danio rerio	18671	ZFIN:ZDB-GENE-080204-52
Danio rerio	24891	ZFIN:ZDB-GENE-080204-52
Saccharomyces cerevisiae S288C	27413	SGD:S000001692
Danio rerio	36428	ZFIN:ZDB-GENE-080204-52
Danio rerio	38726	ZFIN:ZDB-GENE-080204-52

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements