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Multi drug resistance 65

Summary

Gene Symbol

Mdr65

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

38726

PubChem

38726

Alliance of Genome Resources

FB:FBgn0004513

Annotation

Keyword

ATP-binding
Glycoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00748	P-glycoprotein 65

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEP	19545574
renal tubular secretion	IEP	19545574
transmembrane transport	IBA IEA
establishment of glial blood-brain barrier	IDA	19295159
xenobiotic transport	IDA	19295159

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

transmembrane transport

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal tubular secretion

excretion [inference]

renal tubular secretion

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

response to insecticide

localization [inference]

establishment of localization [inference]

transport [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IBA IEA
ATP-binding cassette (ABC) transporter complex	IDA	19295159
pleated septate junction	IDA	19295159

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

septate junction [inference]

pleated septate junction

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GO Term	Evidence Code	PMID
ABC-type transporter activity	IEA
ATP hydrolysis activity	IEA
ATPase-coupled transmembrane transporter activity	IBA
ABC-type xenobiotic transporter activity	IDA	19295159
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
ATP-binding cassette (ABC) transporter complex	PMID:19295159
pleated septate junction	PMID:19295159
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying entries **1 - 10** of 50 in total

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DO ID	Disease Name	Source
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0060643	primary sclerosing cholangitis	Alliance of Genome Resources
DOID:0060750	familial temporal lobe epilepsy 3	Alliance of Genome Resources
DOID:0070223	progressive familial intrahepatic cholestasis 3	Alliance of Genome Resources
DOID:0070229	intrahepatic cholestasis of pregnancy 3	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0080797	nasal type extranodal NK/T-cell lymphoma	Alliance of Genome Resources
DOID:0110893	inflammatory bowel disease 13	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	5243	HGNC:40
Homo sapiens	5244	HGNC:45
Mus musculus	18669	MGI:97568
Mus musculus	18670	MGI:97569
Mus musculus	18671	MGI:97570
Rattus norvegicus	24646	RGD:3318
Rattus norvegicus	24891	RGD:620248
Mus musculus	77706	MGI:1924956
Caenorhabditis elegans	178215	WB:WBGene00003995
Caenorhabditis elegans	180165	WB:WBGene00004003

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements