Ligand-independent caspase activation via DCC
|
|
|
- Appl1
- Casp3
- Casp9
- Cpp32
- Dcc
- Dip13a
- Kiaa1428
- Mch6
|
|
Dual incision in TC-NER
|
- CDK-activating kinase assembly factor MAT1
- Cullin-4A
- Cullin-4B
- Cyclin-H
- Cyclin-dependent kinase 7
- DNA damage-binding protein 1
- DNA excision repair protein ERCC-1
- DNA excision repair protein ERCC-5
- DNA excision repair protein ERCC-6
- DNA excision repair protein ERCC-8
- DNA polymerase delta catalytic subunit
- DNA polymerase delta subunit 2
- DNA polymerase delta subunit 3
- DNA polymerase delta subunit 4
- DNA polymerase epsilon catalytic subunit A
- DNA polymerase epsilon subunit 2
- DNA polymerase epsilon subunit 3
- DNA polymerase epsilon subunit 4
- DNA polymerase kappa
- DNA repair endonuclease XPF
- DNA repair protein complementing XP-A cells homolog
- DNA-directed RNA polymerase II subunit RPB11
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- E3 ubiquitin-protein ligase RBX1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 1
- General transcription factor IIH subunit 2
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 5
- Polyubiquitin-B
- Polyubiquitin-C
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor ISY1 homolog
- Pre-mRNA-splicing factor SYF1
- Proliferating cell nuclear antigen
- RNA helicase aquarius
- Replication factor C subunit 1
- Replication factor C subunit 2
- Replication factor C subunit 3
- Replication factor C subunit 4
- Replication factor C subunit 5
- Replication protein A 14 kDa subunit
- Replication protein A 32 kDa subunit
- Replication protein A 70 kDa DNA-binding subunit
- Transcription elongation factor A protein 1
- UV-stimulated scaffold protein A
- Ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Zinc finger protein 830
|
|
- Aqr
- Btf2p44
- Cak
- Ccdc16
- Ccnh
- Cdk7
- Cdkn7
- Ckn1
- Crk4
- Csa
- Csb
- Cul4a
- Cul4b
- D17Wsu155e
- Ddb1
- Dinb1
- Ercc-1
- Ercc-5
- Ercc1
- Ercc2
- Ercc3
- Ercc4
- Ercc5
- Ercc6
- Ercc8
- Gtf2h1
- Gtf2h2
- Gtf2h3
- Gtf2h4
- Gtf2h5
- Hausp
- Ibf-1
- Isy1
- Kiaa0560
- Kiaa0695
- Kiaa1160
- Kiaa1530
- Mat1
- Mnat1
- Mo15
- Mpk-7
- Mt1a
- Omcg1
- Pcna
- Pold1
- Pold2
- Pold3
- Pold4
- Pole
- Pole1
- Pole2
- Pole3
- Pole4
- Polk
- Polr2a
- Polr2b
- Polr2c
- Polr2d
- Polr2e
- Polr2f
- Polr2g
- Polr2h
- Polr2i
- Polr2j
- Polr2k
- Polr2l
- Prp19
- Prpf19
- Rbx1
- Recc1
- Rfc1
- Rfc2
- Rfc3
- Rfc4
- Rfc5
- Rpa1
- Rpa2
- Rpa3
- Rpa34
- Rpii215
- Rpo2-1
- Rpo2-3
- Rpo2-4
- Rps27a
- Snev
- Syf1
- Tcea1
- Tceat
- Uba52
- Uba80
- Ubb
- Ubc
- Ubcep1
- Ubcep2
- Usp7
- Uvssa
- Xab2
- Xpa
- Xpac
- Xpb
- Xpbc
- Xpd
- Xpf
- Xpg
- Zfp830
- Znf830
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|
Translesion synthesis by POLK
|
|
|
- Dinb1
- Ibf-1
- Mad2b
- Mad2l2
- Pcna
- Polk
- Polz
- Recc1
- Rev1
- Rev1l
- Rev3l
- Rev7
- Rfc1
- Rfc2
- Rfc3
- Rfc4
- Rfc5
- Rpa1
- Rpa2
- Rpa3
- Rpa34
- Rps27a
- Sez4
- Uba52
- Uba80
- Ubb
- Ubc
- Ubcep1
- Ubcep2
|
|
Inhibition of DNA recombination at telomere
|
|
|
- Acd
- Atrx
- Daxx
- Gm14920
- H2a.x
- H2ab1
- H2ab2
- H2ab3
- H2ac11
- H2ac12
- H2ac13
- H2ac15
- H2ac20
- H2ac4
- H2ac6
- H2ac8
- H2afv
- H2afx
- H2aj
- H2av
- H2ax
- H2az2
- H2b-f
- H2b-j
- H2b-l
- H2b-n
- H2bc1
- H2bc11
- H2bc12
- H2bc13
- H2bc14
- H2bc15
- H2bc21
- H2bc26
- H2bc26-ps
- H2bc3
- H2bc4
- H2bc6
- H2bc7
- H2bc8
- H2bc9
- H2bu1
- H2bu1-ps
- H3-3a
- H3-3b
- H3.3a
- H3.3b
- H3f3a
- H3f3b
- H3f4
- H4-12
- H4-53
- H4c1
- H4c11
- H4c12
- H4c14
- H4c16
- H4c2
- H4c3
- H4c4
- H4c6
- H4c8
- H4c9
- H4f16
- Hist1h2ab
- Hist1h2ac
- Hist1h2ae
- Hist1h2af
- Hist1h2ag
- Hist1h2ah
- Hist1h2ai
- Hist1h2ak
- Hist1h2an
- Hist1h2ao
- Hist1h2ap
- Hist1h2ba
- Hist1h2bb
- Hist1h2bc
- Hist1h2be
- Hist1h2bf
- Hist1h2bg
- Hist1h2bh
- Hist1h2bj
- Hist1h2bk
- Hist1h2bl
- Hist1h2bm
- Hist1h2bn
- Hist1h2bp
- Hist1h4a
- Hist1h4b
- Hist1h4c
- Hist1h4d
- Hist1h4f
- Hist1h4h
- Hist1h4i
- Hist1h4j
- Hist1h4k
- Hist1h4m
- Hist2h2aa1
- Hist2h2aa2
- Hist2h2ab
- Hist2h2ac
- Hist2h2be
- Hist2h4
- Hist2h4a
- Hist3h2bb
- Hist3h2bb-ps
- Hist4h4
- Hist5-2ax
- Hp1bp2
- Pot1
- Pot1a
- Rap1
- Terf1
- Terf2
- Terf2ip
- Th2b
- Tin2
- Tinf2
- Trf1
- Trf2
- Xnp
|
|
Phase I - Functionalization of compounds
|
|
|
- Aada
- Aadac
- Abp1
- Ahd-4
- Ahd4
- Ahr
- Ahrr
- Aldh3
- Aldh3a1
- Aldh4
- Aoc1
- Aoc2
- Aoc3
- Arnt
- Arnt2
- BC015286
- Bphl
- Cbr3
- Ces1
- Ces1d
- Ces2b
- Ces3
- Ces3a
- Ces3b
- Cmbl
- Cyb5b
- Cyb5m
- Cyb5r3
- Cyp2b23
- Cyp3a-11
- Cyp3a-13
- Cyp3a-16
- Cyp3a11
- Cyp3a13
- Cyp3a16
- Cyp3a25
- Cyp3a41
- Cyp3a41a
- Cyp3a41b
- Cyp3a44
- Cyp3a57
- Cyp3a59
- Dia1
- Ephx1
- Es31
- Gm4738
- Kiaa0307
- Kiaa1234
- Marc1
- Marc2
- Mg87
- Mosc1
- Mosc2
- Mtarc1
- Mtarc2
- Nmor2
- Nqo2
- Vap1
- cyp3a
|
|
FGFRL1 modulation of FGFR1 signaling
|
|
|
- Aigf
- Fgf-2
- Fgf-3
- Fgf-4
- Fgf-5
- Fgf10
- Fgf17
- Fgf18
- Fgf2
- Fgf22
- Fgf23
- Fgf3
- Fgf4
- Fgf5
- Fgf8
- Fgfr5
- Fgfrl1
- Int-2
- Kfgf
- Spred1
- Spred2
|
|
Insulin receptor recycling
|
|
|
- Atp6a1
- Atp6a2
- Atp6ap1
- Atp6b1
- Atp6b2
- Atp6c
- Atp6c1
- Atp6c2
- Atp6d
- Atp6e
- Atp6e1
- Atp6e2
- Atp6f
- Atp6g1
- Atp6g2
- Atp6g3
- Atp6ip1
- Atp6l
- Atp6m
- Atp6n1
- Atp6n1b
- Atp6s1
- Atp6s14
- Atp6v0a1
- Atp6v0a2
- Atp6v0a4
- Atp6v0b
- Atp6v0c
- Atp6v0d1
- Atp6v0d2
- Atp6v0e
- Atp6v0e1
- Atp6v0e2
- Atp6v1a
- Atp6v1a1
- Atp6v1b1
- Atp6v1b2
- Atp6v1c1
- Atp6v1c2
- Atp6v1d
- Atp6v1e1
- Atp6v1e2
- Atp6v1f
- Atp6v1g1
- Atp6v1g2
- Atp6v1g3
- Atp6v1h
- Atpl
- Ctsd
- Ide
- Ins-1
- Ins1
- Insr
- Lar
- Mvp
- Ng38
- Oc116
- Ptpn1
- Ptprf
- Tcirg1
- Tj6
- Vat2
- Vatc
- Vatd
- Vatf
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|
Aryl hydrocarbon receptor signalling
|
|
|
- Ahr
- Ahrr
- Aip
- Arnt
- Arnt2
- Hsp84
- Hsp84-1
- Hsp90ab1
- Hspc3
- Hspcb
- Kiaa0307
- Kiaa1234
- Ptges3
- Sid3177
- Tebp
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|
CDK-mediated phosphorylation and removal of Cdc6
|
|
|
- Anapc1
- Anapc10
- Anapc11
- Anapc15
- Anapc16
- Anapc2
- Anapc4
- Anapc5
- Anapc6
- Anapc7
- Anapc8
- Apc10
- Apc7
- Ccna
- Ccna1
- Ccna2
- Ccne
- Ccne1
- Ccne2
- Cdc16
- Cdc23
- Cdc26
- Cdc27
- Cdc6
- Cdk2
- Cdkn2
- Cyca
- Cyca2
- D10Ertd641e
- D5Ertd249e
- E2epf
- Fyr
- Fzr
- Fzr1
- Kiaa0072
- Kiaa0077
- Lmp10
- Lmp19
- Lmp2
- Lmp3
- Lmp7
- Lmpc3
- Mc13
- Mcb1
- Mcpr
- Mecl1
- Mmc14
- Mov-34
- Mov34
- Mss1
- P91a
- Pa28b1
- Pad1
- Psma1
- Psma2
- Psma3
- Psma4
- Psma5
- Psma6
- Psma7
- Psma7l
- Psma8
- Psmb1
- Psmb10
- Psmb11
- Psmb2
- Psmb3
- Psmb4
- Psmb5
- Psmb6
- Psmb7
- Psmb8
- Psmb9
- Psmc1
- Psmc2
- Psmc3
- Psmc4
- Psmc5
- Psmc6
- Psmd1
- Psmd10
- Psmd11
- Psmd12
- Psmd13
- Psmd14
- Psmd2
- Psmd3
- Psmd4
- Psmd5
- Psmd6
- Psmd7
- Psmd8
- Psmd9
- Psme1
- Psme2
- Psme3
- Psme4
- Psmf1
- Ring12
- Rps27a
- Sug1
- Sug2
- Tbp1
- Tbp7
- Tsg24
- Tstap91a
- Uba52
- Uba80
- Ubb
- Ubc
- Ubce5
- Ubcep1
- Ubcep2
- Ubch10
- Ubcm3
- Ube2c
- Ube2d1
- Ube2e1
- Ube2s
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|
FLT3 signaling through SRC family kinases
|
|
|
- Flk-2
- Flt-3
- Flt3
- Flt3l
- Flt3lg
- Lck
- Lsk-t
- Syk
- Sykb
- ptk72
|
|
Prolactin receptor signaling
|
|
|
- Cul1
- Gh
- Gh1
- Ghr
- Jak2
- Prl
- Prlr
- Rbx1
- Sh2b1
- Sh2bpsm1
- Skp1
- Skp1a
|
|
Classical antibody-mediated complement activation
|
|
|
- C1qa
- C1qb
- C1qc
- C1qg
- C1r
- C1ra
- C1s
- C1s2
- C1sb
- Crp
- Gm16932
- Gm20730
- Gm5077
- Gm5153
- Igh-3
- Igh-4
- Ighg1
- Ighg2b
- Ighg2c
- Ighg3
- Ighv12-3
- Ighv13-2
- Ighv16-1
- Ighv3-1
- Ighv3-3
- Ighv3-4
- Ighv3-5
- Ighv3-6
- Ighv3-8
- Ighv5-12
- Ighv5-12-4
- Ighv5-16
- Ighv5-17
- Ighv5-4
- Ighv5-6
- Ighv5-9
- Ighv6-3
- Ighv6-4
- Ighv6-5
- Ighv6-6
- Ighv6-7
- Ighv7-3
- Ighv8-11
- Ighv8-13
- Ighv8-2
- Ighv8-4
- Ighv8-5
- Ighv8-6
- Ighv8-8
- Ighv8-9
- Igkv1-110
- Igkv1-117
- Igkv1-122
- Igkv1-131
- Igkv1-132
- Igkv1-133
- Igkv1-135
- Igkv1-88
- Igkv11-125
- Igkv15-103
- Igkv16-104
- Igkv17-121
- Igkv2-109
- Igkv2-112
- Igkv2-137
- Igkv20-101-2
- Igkv8-21
- Igl-5
- Iglc1
- Iglc2
- Iglc3
- Igll1
- Ptx1
|
|
Protein lipoylation
|
|
|
- Dbt
- Dlat
- Dlst
- Fdx1
- Gcsh
- Hirip5
- Lias
- Lip1
- Lipt1
- Lipt2
- Ndufab1
- Nfu1
|
|
Translesion Synthesis by POLH
|
|
|
- Arnip
- Chimp
- Gm505
- Ibf-1
- Kiaa1499
- Npl4
- Nploc4
- Pcna
- Polh
- Rad30a
- Rchy1
- Recc1
- Rfc1
- Rfc2
- Rfc3
- Rfc4
- Rfc5
- Rpa1
- Rpa2
- Rpa3
- Rpa34
- Rps27a
- Sprtn
- Uba52
- Uba80
- Ubb
- Ubc
- Ubcep1
- Ubcep2
- Ufd1
- Ufd1l
- Vcp
- Xpv
- Zfp363
- Znf363
|
|
SUMO is proteolytically processed
|
|
|
- Senp1
- Senp2
- Senp5
- Smt3a
- Smt3b
- Smt3c
- Smt3h1
- Smt3h2
- Smt3h3
- Smt3ip2
- Smt3ip3
- Sumo1
- Sumo2
- Sumo3
- Supr1
- Supr2
- Ubl1
|
|
Vitamin B5 (pantothenate) metabolism
|
|
|
- Aasdhppt
- Fasn
- Gda
- Pank4
- Pdzd11
- Pdzk11
- Slc25a16
- Slc25a42
- Slc5a6
- Vnn1
|
|
p130Cas linkage to MAPK signaling for integrins
|
|
|
- Apbb1ip
- Bcar1
- Cas
- Crk
- Crkas
- Crko
- Fga
- Fgb
- Fgg
- Fn1
- Itga2b
- Itgb3
- Krev-1
- Prel1
- Rap1a
- Rap1b
- Src
- Tln
- Tln1
- Vwf
|
|
Nicotinamide salvaging
|
|
|
- Aibp
- Apoa1bp
- Artd15
- Bal
- Carkd
- Cox-2
- Cox2
- Cyp12
- Cyp8
- Cyp8b1
- D13Ertd275e
- Kiaa0177
- Kiaa1268
- Nampt
- Naprt
- Naprt1
- Naxd
- Naxe
- Nnmt
- Nudt12
- Orctl3
- Parp10
- Parp14
- Parp16
- Parp4
- Parp6
- Parp8
- Parp9
- Pbef1
- Pghs-b
- Ptgis
- Ptgs2
- Rnls
- Slc22a13
- Slc5a8
- Smct
- Smct1
- Tis10
|
|
Aspartate and asparagine metabolism
|
|
|
- Asns
- Aspa
- Aspg
- Folh1
- Gadl1
- Got-2
- Got1
- Got2
- Mopsm
- Naalad1
- Naalad2
- Nat8l
- Slc25a12
- Slc25a13
|
|
Endosomal Sorting Complex Required For Transport (ESCRT)
|
|
|
- Chmp2a
- Chmp2b
- Chmp3
- Chmp4b
- Chmp4c
- Chmp5
- Chmp6
- Chmp7
- D11Moh34
- D11Wsu68e
- Fam125a
- Fam125b
- Hbp
- Hgs
- Hrs
- Mvb12a
- Mvb12b
- Rps27a
- Skd1
- Snf7dc2
- Snf8
- Stam
- Stam1
- Stam2
- Tsg101
- Uba52
- Uba80
- Ubap1
- Ubb
- Ubc
- Ubcep1
- Ubcep2
- Vps24
- Vps25
- Vps28
- Vps36
- Vps37a
- Vps37b
- Vps37c
- Vps37d
- Vps4a
- Vps4b
- Vta1
- Wbscr24
|
|
Glutathione conjugation
|
|
|
- Akr1a1
- Akr1a4
- Es10
- Esd
- Fsc2
- Gm10639
- Gst2
- Gsta
- Gsta1
- Gsta13
- Gsta2
- Gsta3
- Gsta5
- Gstk1
- Gstm1
- Gstm2
- Gstm3
- Gstm4
- Gstm5
- Gstm6
- Gstm7
- Gstm7-7
- Gsto1
- Gsto2
- Gstp1
- Gstp2
- Gstpia
- Gstpib
- Gsts
- Gstt1
- Gstt2
- Gstx
- Gstya
- Gstyc
- Gstz1
- Gtsttl
- Hpgds
- Maai
- Mgst1
- Mgst2
- Mgst3
- Pgds
- Ptgds2
- Sid478
|
|
Negative regulation of FGFR1 signaling
|
|
|
- Aigf
- Cbl
- Erk1
- Erk2
- Fgf-1
- Fgf-2
- Fgf-3
- Fgf-4
- Fgf-5
- Fgf-6
- Fgf-9
- Fgf1
- Fgf10
- Fgf17
- Fgf2
- Fgf20
- Fgf22
- Fgf23
- Fgf3
- Fgf4
- Fgf5
- Fgf6
- Fgf8
- Fgf9
- Fgfa
- Fgfr1
- Flg
- Frs2
- Frs2a
- Hstf2
- Int-2
- Kfgf
- Kl
- Mapk
- Mapk1
- Mapk3
- Prkm1
- Prkm3
- Ptpn11
- Rps27a
- Uba52
- Uba80
- Ubb
- Ubc
- Ubcep1
- Ubcep2
|
|
Regulation of IFNA/IFNB signaling
|
|
|
- Gm12597
- Gm13280
- Hcp
- Hcph
- If1ai1
- If1ai2
- If1ai6
- If1ai8
- Ifa6
- Ifa7
- Ifa8
- Ifa9
- Ifar
- Ifb
- Ifna1
- Ifna11
- Ifna12
- Ifna13
- Ifna14
- Ifna15
- Ifna16
- Ifna2
- Ifna4
- Ifna5
- Ifna6
- Ifna6T
- Ifna7
- Ifna8
- Ifna9
- Ifnab
- Ifnar
- Ifnar1
- Ifnar2
- Ifnb
- Ifnb1
- Jak1
- MuIFN-alpha-A
- OTTMUSG00000007655
- OTTMUSG00000011275
- Ptp1C
- Ptpn1
- Ptpn11
- Ptpn6
- Stat1
- Stat2
- Tyk2
- Ubp43
- Usp18
|
|
Organic anion transporters
|
|
|
- Bnpi
- Dic
- Dnpi
- Gc1
- Gc2
- Nis
- Npt1
- Slc17a1
- Slc17a5
- Slc17a6
- Slc17a7
- Slc17a8
- Slc25a1
- Slc25a10
- Slc25a11
- Slc25a18
- Slc25a22
- Slc5a5
- Slc5a8
- Smct
- Smct1
- Vglut1
- Vglut2
- Vglut3
|
|
Ligand-dependent caspase activation
|
|
|
- Casp8
- Cd14
- Esop1
- Fadd
- Lps
- Ly96
- Md2
- Mort1
- Rinp
- Rip
- Ripk1
- Ticam1
- Ticam2
- Tirp
- Tlr4
- Tram
- Trif
|
|