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MIRAGE
Regulation of Complement cascade

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
C5AR2 ligandsC5AR2:C5AR2 ligandsC5AR2C5aC5AR1:C5aC5AR1C3 convertasesCFB(260-764)C3bC2aCell surface:C4bProperdin oligomerCell surface:C4b:C2aiC3CFH:C3bCFHHost cell surfaceCFH:Host cell surfaceCFH, CFHR3Cell surface:FH,FHR3:C3bCell surface:C3bCell surface:CFH, CFHR3:C3bBbCell surface:C3b:BbCFHR dimersCell surface:C3b:CFHR dimersCFICFICFICFI:CFH:C3biC3bC3CFI:CFH,FHR3:C3bCFI:CFH,FHR3:iC3bCR1:iC3bCR1C3cC3CR1:C3bBb, C4bC2a complexesC4bC2a, C3bBbCR1:C4bCR1:C3bCR2CR2:C3d,C3dg,iC3bC3d, C3dg, iC3bCD19:CD81CR2:C3d,C3dg,iC3b:CD19:CD81CD46CD46:Cell surface:C3bCD46:Cell surface:C4bCFI:CD46, CR1:C4b, C3b complexesCD46, CR1:C4b:C3b complexesC4c, C3fCD46, CR1C4d, iC3bDAFCD55:C3 convertase complexesCD55:C4bCD55:C3bC4b-binding proteinC4-binding protein:C4bC4bC4b-binding protein:Factor IC4dC4cC4 binding protein:C4bC2aC4 binding protein:protein Sprotein SCD59CD59:C5b-C9C5b:C6:C7:C8C9VTN:C5b:C6:C7VTN:C5b:C6:C7:C8:C9C8C5b:C6:C7VTNC4b with hydrolysed thioesterH2OAntigen:IgG:C1 with activated C1R, C1SAntigen:IgG:C1Q:2xActivated C1R:2xActivated C1SC1InhAntigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1C1QActivated C1S:SERPING1Antigen:IgGActivated C1R:SERPING1C5b:C6:C7, C8, C9CLU:C5b:C6:C7, C8, C9CLUC5C5bTC5aTC3a, C5aC3a-desArg, C5a-desArgC3AR1C3AR1:C3aC3a
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_001413 P0C0L5 Complement C4-B view
GL_002853 P04004 Vitronectin view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025