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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
rheumatic heart disease
Summary
- Synonym
-
- rheumatic carditis
- Definition
- A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.
- Super Class
- heart valve disease
External Links
- Disease Ontology
- DOID:0050827
- Mondo Disease Ontology
- MeSH
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 59 | ACTA2 | actin alpha 2, smooth muscle | |
| 581 | BAX | BCL2 associated X, apoptosis regulator | |
| 948 | CD36 | CD36 molecule (CD36 blood group) | |
| 1277 | COL1A1 | collagen type I alpha 1 chain | |
| 1281 | COL3A1 | collagen type III alpha 1 chain | |
| 2597 | GAPDH | glyceraldehyde-3-phosphate dehydrogenase | |
| 3117 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | |
| 3119 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | |
| 3123 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | |
| 3586 | IL10 | interleukin 10 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 17395 | Mmp9 | matrix metallopeptidase 9 | |
| 20613 | Snai1 | snail family zinc finger 1 | |
| 24136 | Zeb2 | zinc finger E-box binding homeobox 2 | |
| 69165 | Cd209b | CD209b antigen | |
| 170776 | Cd209c | CD209c antigen | |
| 170779 | Cd209d | CD209d antigen | |
| 170786 | Cd209a | CD209a antigen |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 174578 | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4 | |
| 174603 | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1 | |
| 176673 | scav-3 | Sensory neuron membrane protein 2 | |
| 176787 | scav-2 | SCAVenger receptor (CD36 family) related | |
| 179991 | zmp-4 | Hemopexin;Peptidase metallopeptidase domain-containing protein | |
| 180351 | W01F3.2 | Uncharacterized protein | |
| 180601 | gpd-3 | Glyceraldehyde-3-phosphate dehydrogenase 3 |
