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metabolic dysfunction-associated steatotic liver disease
Summary
- Synonym
-
- MAFLD
- MASLD
- NAFLD
- metabolic dysfunction-associated fatty liver disease
- metabolic dysfunction-related steatotic liver disease
- metabolic-associated fatty liver disease
- non-alcoholic fatty liver disease
- nonalcoholic fatty liver disease
- Definition
- A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are: (1) Body mass index ≥ 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents. (2) Fasting serum glucose ≥ 5.6 mmol/L, 2-hr post-load glucose levels ≥ 7.8 mmol/L, glycated hemoglobin (HbA1c) ≥ 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose ≥ 11.1 mmol/L (pediatric only). (3) Blood pressure ≥ lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age ≥ 13 years); or specific hypertensive drug treatment. (4) Plasma triglycerides ≥ 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age ≥ 10 years); or lipid lowering treatment. (5) Plasma high-density lipoprotein cholesterol ≤ 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment.
- Super Class
- steatotic liver disease
External Links
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 7941 | PLA2G7 | phospholipase A2 group VII | |
| 8660 | IRS2 | insulin receptor substrate 2 | |
| 9370 | ADIPOQ | adiponectin, C1Q and collagen domain containing | |
| 10135 | NAMPT | nicotinamide phosphoribosyltransferase | |
| 10891 | PPARGC1A | PPARG coactivator 1 alpha | |
| 22933 | SIRT2 | sirtuin 2 | |
| 23409 | SIRT4 | sirtuin 4 | |
| 23417 | MLYCD | malonyl-CoA decarboxylase | |
| 51548 | SIRT6 | sirtuin 6 | |
| 57678 | GPAM | glycerol-3-phosphate acyltransferase, mitochondrial |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11364 | Acadm | acyl-Coenzyme A dehydrogenase, medium chain | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 14380 | G6pd2 | glucose-6-phosphate dehydrogenase 2 | |
| 14381 | G6pdx | glucose-6-phosphate dehydrogenase X-linked | |
| 16846 | Lep | leptin | |
| 16847 | Lepr | leptin receptor | |
| 19017 | Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | |
| 21898 | Tlr4 | toll-like receptor 4 | |
| 21926 | Tnf | tumor necrosis factor | |
| 22228 | Ucp2 | uncoupling protein 2 (mitochondrial, proton carrier) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24158 | Acadm | acyl-CoA dehydrogenase medium chain | |
| 24377 | G6pd | glucose-6-phosphate dehydrogenase | |
| 24536 | Lepr | leptin receptor | |
| 24651 | Pklr | pyruvate kinase L/R | |
| 24835 | Tnf | tumor necrosis factor | |
| 25608 | Lep | leptin | |
| 29260 | Tlr4 | toll-like receptor 4 | |
| 54315 | Ucp2 | uncoupling protein 2 | |
| 83516 | Ppargc1a | PPARG coactivator 1 alpha | |
| 252900 | Dgat2 | diacylglycerol O-acyltransferase 2 |
Related Glycoprotein
