metabolic dysfunction-associated steatotic liver disease

Summary
Synonym
  • MAFLD
  • MASLD
  • NAFLD
  • metabolic dysfunction-associated fatty liver disease
  • metabolic dysfunction-related steatotic liver disease
  • metabolic-associated fatty liver disease
  • non-alcoholic fatty liver disease
  • nonalcoholic fatty liver disease
Definition
A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are: (1) Body mass index ≥ 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents. (2) Fasting serum glucose ≥ 5.6 mmol/L, 2-hr post-load glucose levels ≥ 7.8 mmol/L, glycated hemoglobin (HbA1c) ≥ 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose ≥ 11.1 mmol/L (pediatric only). (3) Blood pressure ≥ lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age ≥ 13 years); or specific hypertensive drug treatment. (4) Plasma triglycerides ≥ 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age ≥ 10 years); or lipid lowering treatment. (5) Plasma high-density lipoprotein cholesterol ≤ 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment.
Super Class
steatotic liver disease
Disease Ontology
DOID:0080208
Mondo Disease Ontology
MeSH
OMIM
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 61 - 70 of 88 in total
Gene ID Gene Symbol Description Source
9332 CD163 CD163 molecule
9370 ADIPOQ adiponectin, C1Q and collagen domain containing
10135 NAMPT nicotinamide phosphoribosyltransferase
10226 PLIN3 perilipin 3
10891 PPARGC1A PPARG coactivator 1 alpha
11093 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13
22933 SIRT2 sirtuin 2
23409 SIRT4 sirtuin 4
23410 SIRT3 sirtuin 3
23411 SIRT1 sirtuin 1
Displaying entries 51 - 60 of 80 in total
Gene ID Gene Symbol Description Source
27409 Abcg5 ATP binding cassette subfamily G member 5
29817 Igfbp7 insulin-like growth factor binding protein 7
50721 Sirt6 sirtuin 6
56458 Foxo1 forkhead box O1
56690 Mlycd malonyl-CoA decarboxylase
58805 Mlxipl MLX interacting protein-like
59027 Nampt nicotinamide phosphoribosyltransferase
64383 Sirt2 sirtuin 2
66905 Plin3 perilipin 3
67470 Abcg8 ATP binding cassette subfamily G member 8
Displaying entries 11 - 20 of 45 in total
Gene ID Gene Symbol Description Source
24835 Tnf tumor necrosis factor
25303 Abcc2 ATP binding cassette subfamily C member 2
25325 Il10 interleukin 10
25363 Acadvl acyl-CoA dehydrogenase, very long chain
25467 Irs1 insulin receptor substrate 1
25608 Lep leptin
25645 Adrb3 adrenoceptor beta 3
25675 Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase
25718 Igf1r insulin-like growth factor 1 receptor
29199 Hfe homeostatic iron regulator
Displaying entries 1 - 10 of 11 in total
Gene ID Gene Symbol Description Source
31480 Sirt4 Sirtuin 4
32974 Zw Zwischenferment
35362 Mtp Microsomal triacylglycerol transfer protein
36428 Mdr49 Multi drug resistance 49
38726 Mdr65 Multi drug resistance 65
41549 Octbeta2R Octopamine beta2 receptor
42549 InR Insulin-like receptor
42620 PyK Pyruvate kinase
42652 Octbeta1R Octopamine beta1 receptor
42803 Hmgcr HMG Coenzyme A reductase
Displaying all 4 entries
Gene ID Gene Symbol Description Source
406207 mttp microsomal triglyceride transfer protein
447803 pon1 paraoxonase 1
565316 dgat2 diacylglycerol O-acyltransferase 2
768121 foxo1a forkhead box O1 a
Displaying all 4 entries
Gene ID Gene Symbol Description Source Organism
395003 dgat2 diacylglycerol O-acyltransferase 2 Xenopus tropicalis (tropical clawed frog)
398800 dgat2.L diacylglycerol O-acyltransferase 2 L homeolog Xenopus laevis (African clawed frog)
399170 akt1.S AKT serine/threonine kinase 1 S homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
Displaying entries 1 - 10 of 13 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
175410 daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
176852 dsc-4 Microsomal triglyceride transfer protein homolog
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
178046 gspd-1 Glucose-6-phosphate 1-dehydrogenase
178215 pgp-1 Multidrug resistance protein pgp-1
178672 srp-3 Serpin domain-containing protein
180289 mrp-7 Multidrug resistance protein mrp-7
180408 mrp-2 Multidrug resistance-associated protein 1
180409 mrp-1 Multidrug resistance-associated protein 1
Displaying entries 1 - 10 of 14 in total
Gene ID Gene Symbol Description Source
851171 HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
851193 CDC19 pyruvate kinase CDC19
852803 HNM1 Hnm1p
853590 VPS70 putative zinc metalloprotease
853671 STE6 ATP-binding cassette a-factor transporter STE6
854080 YOL075C uncharacterized protein
854419 DGA1 diacylglycerol O-acyltransferase
854430 TRE2 putative zinc metalloprotease
854529 PYK2 pyruvate kinase PYK2
854900 HMG1 hydroxymethylglutaryl-CoA reductase (NADPH) HMG1

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