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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alzheimer's disease
Summary
- Synonym
-
- Alzheimer disease
- Alzheimers dementia
- Definition
- A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
- Super Class
- tauopathy
External Links
- Disease Ontology
- DOID:10652
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
-
- 2174818
- 2174917
- 2174969
- 2174990
- 2174994
- 2174998
- 2177097
- 2177120
- 2652360
- 2652361
- 2652362
- 2652363
- 2652447
- 2652553
- 2662716
- 2684657
- 3029285
- 3044184
- 3045183
- 3045186
- 3510652
- 3577843
- 3582996
- 3589555
- 3611210
- 3611211
- 3618601
- 3624416
- 3639711
- 3639713
- 3653709
- 3663447
- 3663620
- 3663621
- 3663749
- 3663751
- 3665286
- 3665287
- 3693295
- 3693439
- 3693440
- 3693491
- 3696575
- 3696576
- 3697817
- 3702925
- 3709152
- 3709154
- 3709182
- 3710761
- 3710763
- 3710766
- 3717255
- 3717577
- 3718076
- 3718515
- 3720208
- 3720209
- 3720676
- 3720677
- 3720700
- 3720701
- 3720702
- 3720731
- 3720782
- 3720946
- 3721530
- 3721531
- 3721541
- 3721542
- 3721938
- 3722063
- 3722101
- 3722102
- 3722143
- 3722160
- 3722393
- 3769910
- 3771317
- 3784684
- 3829507
- 4355229
- 4355230
- 4366531
- 4367205
- 4367786
- 4412051
- 4417912
- 4438223
- 4818990
- 4819951
- 4843219
- 4847595
- 4882081
- 4943741
- 5003275
- 5003459
- 5003460
- 5003461
- 5003462
- 5003463
- 5003464
- 5003501
- 5008417
- 5008418
- 5014041
- 5050413
- 5051941
- 5051942
- 5052112
- 5052119
- 5052120
- 5140748
- 5294357
- 5294359
- 5301407
- 5305067
- 5313530
- 5427915
- 5428425
- 5433612
- 5433613
- 5435319
- 5442379
- 5462366
- 5463430
- 5463438
- 5465558
- 5471581
- 5491627
- 5511058
- 5512698
- 5512699
- 5521287
- 5550547
- 5550582
- 5553465
- 5554193
- 5559229
- 5559449
- 5569760
- 5578629
- 5581429
- 5581681
- 5604616
- 5629689
- 5634332
- 5638672
- 5638675
- 5646171
- 5646215
- 5699096
- 5701399
- 5708587
- 5754382
- 5754385
- 5755045
- 5790841
- 5792143
- 5803810
- 5811870
- 5812135
- 5829782
- 6257021
- 6257025
- 6314698
- 6324682
- 6392258
- 7608058
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 7804 | LRP8 | LDL receptor related protein 8 | |
| 8574 | AKR7A2 | aldo-keto reductase family 7 member A2 | |
| 8639 | AOC3 | amine oxidase copper containing 3 | |
| 8660 | IRS2 | insulin receptor substrate 2 | |
| 8754 | ADAM9 | ADAM metallopeptidase domain 9 | |
| 8772 | FADD | Fas associated via death domain | |
| 8829 | NRP1 | neuropilin 1 | |
| 9131 | AIFM1 | apoptosis inducing factor mitochondria associated 1 | |
| 9370 | ADIPOQ | adiponectin, C1Q and collagen domain containing | |
| 9446 | GSTO1 | glutathione S-transferase omega 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 26926 | Aifm1 | apoptosis-inducing factor, mitochondrion-associated 1 | |
| 27425 | Atp5mg | ATP synthase membrane subunit g | |
| 30052 | Pcsk1n | proprotein convertase subtilisin/kexin type 1 inhibitor | |
| 53333 | Tomm40 | translocase of outer mitochondrial membrane 40 | |
| 56175 | Bace2 | beta-site APP-cleaving enzyme 2 | |
| 56320 | Dbn1 | drebrin 1 | |
| 56445 | Dnaja2 | DnaJ heat shock protein family (Hsp40) member A2 | |
| 56637 | Gsk3b | glycogen synthase kinase 3 beta | |
| 59287 | Ncstn | nicastrin | |
| 67264 | Ndufb8 | NADH:ubiquinone oxidoreductase subunit B8 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 29412 | Adra1a | adrenoceptor alpha 1A | |
| 29473 | Aoc3 | amine oxidase, copper containing 3 | |
| 29489 | Dync1h1 | dynein cytoplasmic 1 heavy chain 1 | |
| 29527 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | |
| 29539 | Aldh2 | aldehyde dehydrogenase 2 family member | |
| 29595 | Htr2a | 5-hydroxytryptamine receptor 2A | |
| 29650 | Adam10 | ADAM metallopeptidase domain 10 | |
| 29715 | Slc8a1 | solute carrier family 8 member A1 | |
| 29721 | Hivep2 | HIVEP zinc finger 2 | |
| 50654 | Ctss | cathepsin S |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31002 | Appl | beta amyloid protein precursor-like | |
| 31248 | sgg | shaggy | |
| 31293 | N | Notch | |
| 31364 | Fas2 | Fasciclin 2 | |
| 31547 | Nep1 | Neprilysin 1 | |
| 31792 | Nrg | Neuroglian | |
| 32342 | amrt | amaretto | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 33005 | Nep3 | Neprilysin 3 | |
| 33007 | Dop2R | Dopamine 2-like receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30262 | ins | preproinsulin | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 30705 | fgfr1a | fibroblast growth factor receptor 1a | |
| 30718 | notch1a | notch receptor 1a | |
| 58133 | ngfb | nerve growth factor b (beta polypeptide) | |
| 114549 | ache | acetylcholinesterase (Yt blood group) | |
| 317743 | gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 394082 | slc18a3b | solute carrier family 18 member 3b | |
| 406367 | gapdhs | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | |
| 436913 | tm2d2 | TM2 domain containing 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373644 | ldlr.S | low density lipoprotein receptor S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378605 | htr1a.L | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog | Xenopus laevis (African clawed frog) | |
| 380259 | gapdh.S | glyceraldehyde-3-phosphate dehydrogenase S homeolog | Xenopus laevis (African clawed frog) | |
| 380298 | eno1.S | enolase 1 S homeolog | Xenopus laevis (African clawed frog) | |
| 380307 | bace2.L | beta-secretase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 397713 | psen2.S | presenilin 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397757 | ldlr.L | low density lipoprotein receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171905 | ace-2 | Carboxylic ester hydrolase | |
| 171999 | poml-2 | Arylesterase | |
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 172689 | sup-17 | Disintegrin and metalloproteinase domain-containing protein 10 homolog | |
| 172703 | unc-29 | Acetylcholine receptor subunit beta-type unc-29 | |
| 172905 | aph-2 | Nicastrin | |
| 173685 | nep-11 | Neprilysin-11 | |
| 173794 | vab-1 | Ephrin receptor 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850812 | YPS3 | aspartyl protease | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
| 851950 | YPS7 | putative aspartic endopeptidase | |
| 852264 | PEP1 | type I sorting receptor | |
| 852543 | VVS1 | Vvs1p | |
| 852702 | XRN1 | chromatin-binding exonuclease XRN1 | |
| 852806 | HSF1 | stress-responsive transcription factor HSF1 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853169 | ENO1 | phosphopyruvate hydratase ENO1 | |
| 853233 | VTH2 | signal sequence-binding protein |
