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asthma
Summary
- Synonym
-
- bronchial hyperreactivity
- chronic obstructive asthma
- chronic obstructive asthma with acute exacerbation
- chronic obstructive asthma with status asthmaticus
- Definition
- A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
- Super Class
- bronchial disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2908 | NR3C1 | nuclear receptor subfamily 3 group C member 1 | |
| 3106 | HLA-B | major histocompatibility complex, class I, B | |
| 3113 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | |
| 3115 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | |
| 3117 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | |
| 3118 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 | |
| 3119 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | |
| 3122 | HLA-DRA | major histocompatibility complex, class II, DR alpha | |
| 3123 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | |
| 3125 | HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24180 | Agtr1a | angiotensin II receptor, type 1a | |
| 24628 | Pdgfb | platelet derived growth factor subunit B | |
| 24929 | Ptger3 | prostaglandin E receptor 3 | |
| 25245 | Bdkrb2 | bradykinin receptor B2 | |
| 25262 | Itpr1 | inositol 1,4,5-trisphosphate receptor, type 1 | |
| 25325 | Il10 | interleukin 10 | |
| 25704 | Il2ra | interleukin 2 receptor subunit alpha | |
| 29397 | Ccl11 | C-C motif chemokine ligand 11 | |
| 116553 | Il13 | interleukin 13 | |
| 117064 | Vip | vasoactive intestinal peptide |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P11229 | Muscarinic acetylcholine receptor M1 | |
| P11245 | Arylamine N-acetyltransferase 2 | |
| P12821 | Angiotensin-converting enzyme | |
| P12830 | Cadherin-1 | |
| P13500 | C-C motif chemokine 2 | |
| P13501 | C-C motif chemokine 5 | |
| P13569 | Cystic fibrosis transmembrane conductance regulator | |
| P14174 | Macrophage migration inhibitory factor | |
| P14780 | Matrix metalloproteinase-9 | |
| P14784 | Interleukin-2 receptor subunit beta |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P16382 | Interleukin-4 receptor subunit alpha | |
| Q9D2L4 | Integrin beta |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01283 | VIP peptides | |
| P06399 | Fibrinogen alpha chain | |
| P08650 | Complement C5 | |
| P25023 | B2 bradykinin receptor | |
| P25095 | Type-1 angiotensin II receptor A | |
| P26897 | Interleukin-2 receptor subunit alpha | |
| P29456 | Interleukin-10 | |
| P29994 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | |
| P34980 | Prostaglandin E2 receptor EP3 subtype | |
| P35763 | Perforin-1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| Q9VP04 | ORM1-like protein |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001426 | Non-Mendelian inheritance |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002099 | Asthma |
