amyotrophic lateral sclerosis

Summary
Synonym
  • ALS
  • Lou Gehrig's disease
  • motor neuron disease, bulbar
Definition
A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Super Class
motor neuron disease
Disease Ontology
DOID:332
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
OMIM
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 11 - 20 of 73 in total
Gene ID Gene Symbol Description Source
2521 FUS FUS RNA binding protein
2660 MSTN myostatin
2668 GDNF glial cell derived neurotrophic factor
2805 GOT1 glutamic-oxaloacetic transaminase 1
2896 GRN granulin precursor
2931 GSK3A glycogen synthase kinase 3 alpha
2932 GSK3B glycogen synthase kinase 3 beta
3084 NRG1 neuregulin 1
3146 HMGB1 high mobility group box 1
3480 IGF1R insulin like growth factor 1 receptor
Displaying entries 41 - 50 of 55 in total
Gene ID Gene Symbol Description Source
56637 Gsk3b glycogen synthase kinase 3 beta
74018 Als2 alsin Rho guanine nucleotide exchange factor
74772 Atp13a2 ATPase type 13A2
83995 Mmp1a matrix metallopeptidase 1a (interstitial collagenase)
94232 Ubqln4 ubiquilin 4
208727 Hdac4 histone deacetylase 4
224088 Atp13a3 ATPase type 13A3
233908 Fus fused in sarcoma
237868 Sarm1 sterile alpha and HEAT/Armadillo motif containing 1
268878 Atp13a5 ATPase type 13A5
Displaying entries 11 - 20 of 34 in total
Gene ID Gene Symbol Description Source
25715 Slc11a2 solute carrier family 11 member 2
25718 Igf1r insulin-like growth factor 1 receptor
29143 Grn granulin precursor
29152 Mstn myostatin
29167 Dctn1 dynactin subunit 1
29272 Dpp6 dipeptidyl peptidase like 6
29482 Slc1a2 solute carrier family 1 member 2
29527 Ptgs2 prostaglandin-endoperoxide synthase 2
50686 Gsk3a glycogen synthase kinase 3 alpha
81686 Mmp2 matrix metallopeptidase 2
Displaying all 9 entries
Gene ID Gene Symbol Description Source
31248 sgg shaggy
36232 Sod3 Superoxide dismutase 3
38657 vn vein
38895 Sarm Sterile alpha and Armadillo motif
42490 Mvl Malvolio
42549 InR Insulin-like receptor
43223 Lerp lysosomal enzyme receptor protein
43469 Ptp99A Protein tyrosine phosphatase 99A
44811 E(bx) Enhancer of bithorax
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
403143 sarm1 sterile alpha and TIR motif containing 1
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
798441 mstnb myostatin b
100004455 epoa erythropoietin a
Displaying all 4 entries
Gene ID Gene Symbol Description Source Organism
380341 pon2.L paraoxonase 2 L homeolog Xenopus laevis (African clawed frog)
432039 pon2.S paraoxonase 2 S homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
779087 gdnf.L glial cell derived neurotrophic factor L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
175182 ver-1 Protein ver-1
175237 daf-7 Dauer larva development regulatory growth factor daf-7
175410 daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
175502 tir-1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
177044 smf-3 NRAMP-like transporter smf-3
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
177882 glt-3 Putative sodium-dependent excitatory amino acid transporter glt-3
178748 zmp-3 Matrix metalloproteinase-C
179991 zmp-4 Hemopexin;Peptidase metallopeptidase domain-containing protein
180042 dpf-1 Dipeptidyl peptidase family member 1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
850721 SMF3 putative divalent metal ion transporter SMF3
854394 STE13 Ste13p

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