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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
frontotemporal dementia
Summary
- Synonym
-
- Wilhemsen-Lynch disease
- frontotemporal lobar degeneration
- multiple system tauopathy with presenile dementia
- pallidopontonigral degeneration
- Definition
- A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.
- Super Class
- brain disease dementia
External Links
- Disease Ontology
- DOID:9255
- Mondo Disease Ontology
- MeSH
- UMLS
- ORDO
- OMIM
- GARD
- MGI genotype (from TogoID)
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 14030 | Ewsr1 | Ewing sarcoma breakpoint region 1 | |
| 14824 | Grn | granulin | |
| 17758 | Map4 | microtubule-associated protein 4 | |
| 17762 | Mapt | microtubule-associated protein tau | |
| 18039 | Nefl | neurofilament, light polypeptide | |
| 54609 | Ubqln2 | ubiquilin 2 | |
| 56175 | Bace2 | beta-site APP-cleaving enzyme 2 | |
| 83433 | Trem2 | triggering receptor expressed on myeloid cells 2 | |
| 94232 | Ubqln4 | ubiquilin 4 | |
| 233908 | Fus | fused in sarcoma |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 380307 | bace2.L | beta-secretase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 398806 | bace2.S | beta-secretase 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 399258 | psen1.L | presenilin 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 100216145 | bace2 | beta-secretase 2 | Xenopus tropicalis (tropical clawed frog) |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0006892 | Frontotemporal cerebral atrophy |
| HP:0006977 | Deficit in grammar |
| HP:0007112 | Temporal cortical atrophy |
| HP:0010523 | Alexia |
| HP:0010526 | Dysgraphia |
| HP:0011204 | EEG with continuous slow activity |
| HP:0012658 | Abnormal brain FDG positron emission tomography |
| HP:0100256 | Senile plaques |
| HP:0100315 | Lewy bodies |
| HP:0000709 | Psychosis |
