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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alzheimer's disease
Summary
- Synonym
-
- Alzheimer disease
- Alzheimers dementia
- Definition
- A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
- Super Class
- tauopathy
External Links
- Disease Ontology
- DOID:10652
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
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- 2174818
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- 2684657
- 3029285
- 3044184
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- 3510652
- 3577843
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- 3722101
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- 5465558
- 5471581
- 5491627
- 5511058
- 5512698
- 5512699
- 5521287
- 5550547
- 5550582
- 5553465
- 5554193
- 5559229
- 5559449
- 5569760
- 5578629
- 5581429
- 5581681
- 5604616
- 5629689
- 5634332
- 5638672
- 5638675
- 5646171
- 5646215
- 5699096
- 5701399
- 5708587
- 5754382
- 5754385
- 5755045
- 5790841
- 5792143
- 5803810
- 5811870
- 5812135
- 5829782
- 6257021
- 6257025
- 6314698
- 6324682
- 6392258
- 7608058
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 2 | A2M | alpha-2-macroglobulin | |
| 18 | ABAT | 4-aminobutyrate aminotransferase | |
| 19 | ABCA1 | ATP binding cassette subfamily A member 1 | |
| 37 | ACADVL | acyl-CoA dehydrogenase very long chain | |
| 43 | ACHE | acetylcholinesterase (Yt blood group) | |
| 102 | ADAM10 | ADAM metallopeptidase domain 10 | |
| 142 | PARP1 | poly(ADP-ribose) polymerase 1 | |
| 148 | ADRA1A | adrenoceptor alpha 1A | |
| 155 | ADRB3 | adrenoceptor beta 3 | |
| 177 | AGER | advanced glycosylation end-product specific receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11303 | Abca1 | ATP-binding cassette, sub-family A member 1 | |
| 11370 | Acadvl | acyl-Coenzyme A dehydrogenase, very long chain | |
| 11421 | Ace | angiotensin I converting enzyme | |
| 11423 | Ache | acetylcholinesterase | |
| 11438 | Chrna4 | cholinergic receptor, nicotinic, alpha polypeptide 4 | |
| 11441 | Chrna7 | cholinergic receptor, nicotinic, alpha polypeptide 7 | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11487 | Adam10 | a disintegrin and metallopeptidase domain 10 | |
| 11491 | Adam17 | a disintegrin and metallopeptidase domain 17 | |
| 11495 | Adam2 | a disintegrin and metallopeptidase domain 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24153 | A2m | alpha-2-macroglobulin | |
| 24179 | Agt | angiotensinogen | |
| 24180 | Agtr1a | angiotensin II receptor, type 1a | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24232 | C3 | complement C3 | |
| 24253 | Cebpb | CCAAT/enhancer binding protein beta | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24318 | Drd2 | dopamine receptor D2 | |
| 24333 | Eno1 | enolase 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31002 | Appl | beta amyloid protein precursor-like | |
| 31248 | sgg | shaggy | |
| 31293 | N | Notch | |
| 31364 | Fas2 | Fasciclin 2 | |
| 31547 | Nep1 | Neprilysin 1 | |
| 31792 | Nrg | Neuroglian | |
| 32342 | amrt | amaretto | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 33005 | Nep3 | Neprilysin 3 | |
| 33007 | Dop2R | Dopamine 2-like receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 447803 | pon1 | paraoxonase 1 | |
| 555443 | plcd1a | phospholipase C, delta 1a | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 559347 | slc18a3a | solute carrier family 18 member 3a | |
| 560788 | parp1 | poly (ADP-ribose) polymerase 1 | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 100004455 | epoa | erythropoietin a | |
| 100093710 | tm2d1 | TM2 domain containing 1 | |
| 100093711 | tm2d3 | TM2 domain containing 3 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373644 | ldlr.S | low density lipoprotein receptor S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378605 | htr1a.L | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog | Xenopus laevis (African clawed frog) | |
| 380259 | gapdh.S | glyceraldehyde-3-phosphate dehydrogenase S homeolog | Xenopus laevis (African clawed frog) | |
| 380298 | eno1.S | enolase 1 S homeolog | Xenopus laevis (African clawed frog) | |
| 380307 | bace2.L | beta-secretase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 397713 | psen2.S | presenilin 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397757 | ldlr.L | low density lipoprotein receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 176282 | lin-12 | lin-12/Notch intracellular domain | |
| 176581 | Y66D12A.21 | TM2 domain-containing protein Y66D12A.21 | |
| 176673 | scav-3 | Sensory neuron membrane protein 2 | |
| 176787 | scav-2 | SCAVenger receptor (CD36 family) related | |
| 177078 | lad-2 | Ig-like domain-containing protein;Neuroglian | |
| 177343 | skn-1 | BZIP domain-containing protein;Protein skinhead-1 | |
| 177372 | cpi-1 | Cystatin cpi-1 | |
| 177608 | sph-1 | MARVEL domain-containing protein | |
| 178672 | srp-3 | Serpin domain-containing protein | |
| 179197 | cri-2 | Putative metalloproteinase inhibitor tag-225 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850812 | YPS3 | aspartyl protease | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
| 851950 | YPS7 | putative aspartic endopeptidase | |
| 852264 | PEP1 | type I sorting receptor | |
| 852543 | VVS1 | Vvs1p | |
| 852702 | XRN1 | chromatin-binding exonuclease XRN1 | |
| 852806 | HSF1 | stress-responsive transcription factor HSF1 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853169 | ENO1 | phosphopyruvate hydratase ENO1 | |
| 853233 | VTH2 | signal sequence-binding protein |
