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Lewy body dementia
Summary
- Synonym
-
- Dementia with Lewy bodies
- Diffuse Lewy body disease
- Lewy body disease
- Senile dementia of the Lewy body type
- Definition
- A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
- Super Class
- dementia
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 4133 | MAP2 | microtubule associated protein 2 | |
| 4747 | NEFL | neurofilament light chain | |
| 4804 | NGFR | nerve growth factor receptor | |
| 4843 | NOS2 | nitric oxide synthase 2 | |
| 5111 | PCNA | proliferating cell nuclear antigen | |
| 5653 | KLK6 | kallikrein related peptidase 6 | |
| 6620 | SNCB | synuclein beta | |
| 6622 | SNCA | synuclein alpha | |
| 6623 | SNCG | synuclein gamma | |
| 23435 | TARDBP | TAR DNA binding protein |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24483 | Igf2 | insulin-like growth factor 2 | |
| 24596 | Ngfr | nerve growth factor receptor | |
| 25302 | Chrna7 | cholinergic receptor nicotinic alpha 7 subunit | |
| 25590 | Chrna4 | cholinergic receptor nicotinic alpha 4 subunit | |
| 25595 | Map2 | microtubule-associated protein 2 | |
| 25718 | Igf1r | insulin-like growth factor 1 receptor | |
| 25737 | Pcna | proliferating cell nuclear antigen | |
| 29219 | Snca | synuclein alpha | |
| 64347 | Sncg | synuclein, gamma | |
| 83613 | Nefl | neurofilament light chain |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 34304 | nAChRalpha6 | nicotinic Acetylcholine Receptor alpha6 | |
| 42549 | InR | Insulin-like receptor | |
| 42919 | nAChRalpha2 | nicotinic Acetylcholine Receptor alpha2 | |
| 42920 | nAChRbeta2 | nicotinic Acetylcholine Receptor beta2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001300 | Parkinsonism |
| HP:0000726 | Dementia |
| HP:0007159 | Fluctuations in consciousness |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002367 | Visual hallucination |
| HP:0100315 | Lewy bodies |
| HP:0000746 | Delusion |
