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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12 | SERPINA3 | serpin family A member 3 | |
| 153 | ADRB1 | adrenoceptor beta 1 | |
| 154 | ADRB2 | adrenoceptor beta 2 | |
| 177 | AGER | advanced glycosylation end-product specific receptor | |
| 355 | FAS | Fas cell surface death receptor | |
| 356 | FASLG | Fas ligand | |
| 624 | BDKRB2 | bradykinin receptor B2 | |
| 718 | C3 | complement C3 | |
| 727 | C5 | complement C5 | |
| 728 | C5AR1 | complement C5a receptor 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 17250 | Abcc1 | ATP-binding cassette, sub-family C member 1 | |
| 17329 | Cxcl9 | C-X-C motif chemokine ligand 9 | |
| 17395 | Mmp9 | matrix metallopeptidase 9 | |
| 17523 | Mpo | myeloperoxidase | |
| 17829 | Muc1 | mucin 1, transmembrane | |
| 17833 | Muc5ac | mucin 5, subtypes A and C, tracheobronchial/gastric | |
| 18024 | Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | |
| 18205 | Ntf3 | neurotrophin 3 | |
| 18211 | Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | |
| 18793 | Plaur | plasminogen activator, urokinase receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24232 | C3 | complement C3 | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24260 | Chrm3 | cholinergic receptor, muscarinic 3 | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24297 | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24407 | Grik5 | glutamate ionotropic receptor kainate type subunit 5 | |
| 24410 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | |
| 24464 | Hp | haptoglobin | |
| 24536 | Lepr | leptin receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 791973 | cxcr3.2 | chemokine (C-X-C motif) receptor 3, tandem duplicate 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 108697308 | adrb1.L | adrenoceptor beta 1 L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 178269 | lev-1 | Acetylcholine receptor subunit beta-type lev-1 | |
| 178672 | srp-3 | Serpin domain-containing protein | |
| 179197 | cri-2 | Putative metalloproteinase inhibitor tag-225 | |
| 179235 | acr-16 | Acetylcholine receptor subunit alpha-type acr-16 | |
| 179962 | gar-3 | Muscarinic acetylcholine receptor gar-3 | |
| 179991 | zmp-4 | Hemopexin;Peptidase metallopeptidase domain-containing protein | |
| 180289 | mrp-7 | Multidrug resistance protein mrp-7 | |
| 180351 | W01F3.2 | Uncharacterized protein | |
| 180408 | mrp-2 | Multidrug resistance-associated protein 1 | |
| 180409 | mrp-1 | Multidrug resistance-associated protein 1 |
