amyotrophic lateral sclerosis

Summary
Synonym
  • ALS
  • Lou Gehrig's disease
  • motor neuron disease, bulbar
Definition
A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Super Class
motor neuron disease
Disease Ontology
DOID:332
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
OMIM
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 31 - 40 of 73 in total
Gene ID Gene Symbol Description Source
4741 NEFM neurofilament medium chain
4744 NEFH neurofilament heavy chain
4747 NEFL neurofilament light chain
4780 NFE2L2 NFE2 like bZIP transcription factor 2
4891 SLC11A2 solute carrier family 11 member 2
5176 SERPINF1 serpin family F member 1
5228 PGF placental growth factor
5445 PON2 paraoxonase 2
5446 PON3 paraoxonase 3
5610 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2
Displaying entries 51 - 55 of 55 in total
Gene ID Gene Symbol Description Source
269823 Pon3 paraoxonase 3
330260 Pon2 paraoxonase 2
380684 Nefh neurofilament, heavy polypeptide
382018 Unc13a unc-13 homolog A
606496 Gsk3a glycogen synthase kinase 3 alpha
Displaying entries 31 - 34 of 34 in total
Gene ID Gene Symbol Description Source
296851 Pon2 paraoxonase 2
312086 Pon3 paraoxonase 3
317396 Ubqln2 ubiquilin 2
367171 Map4 microtubule-associated protein 4
Displaying all 9 entries
Gene ID Gene Symbol Description Source
31248 sgg shaggy
36232 Sod3 Superoxide dismutase 3
38657 vn vein
38895 Sarm Sterile alpha and Armadillo motif
42490 Mvl Malvolio
42549 InR Insulin-like receptor
43223 Lerp lysosomal enzyme receptor protein
43469 Ptp99A Protein tyrosine phosphatase 99A
44811 E(bx) Enhancer of bithorax
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
403143 sarm1 sterile alpha and TIR motif containing 1
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
798441 mstnb myostatin b
100004455 epoa erythropoietin a
Displaying all 4 entries
Gene ID Gene Symbol Description Source Organism
380341 pon2.L paraoxonase 2 L homeolog Xenopus laevis (African clawed frog)
432039 pon2.S paraoxonase 2 S homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
779087 gdnf.L glial cell derived neurotrophic factor L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
175182 ver-1 Protein ver-1
175237 daf-7 Dauer larva development regulatory growth factor daf-7
175410 daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
175502 tir-1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
177044 smf-3 NRAMP-like transporter smf-3
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
177882 glt-3 Putative sodium-dependent excitatory amino acid transporter glt-3
178748 zmp-3 Matrix metalloproteinase-C
179991 zmp-4 Hemopexin;Peptidase metallopeptidase domain-containing protein
180042 dpf-1 Dipeptidyl peptidase family member 1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
850721 SMF3 putative divalent metal ion transporter SMF3
854394 STE13 Ste13p

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