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MIRAGE
type 1 diabetes mellitus
Summary
- Synonym
-
- IDDM
- insulin-dependent diabetes mellitus
- type I diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
- Super Class
- autoimmune disease of endocrine system diabetes mellitus
External Links
- Disease Ontology
- DOID:9744
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
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Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 3119 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | |
| 3123 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | |
| 3291 | HSD11B2 | hydroxysteroid 11-beta dehydrogenase 2 | |
| 3383 | ICAM1 | intercellular adhesion molecule 1 | |
| 3482 | IGF2R | insulin like growth factor 2 receptor | |
| 3486 | IGFBP3 | insulin like growth factor binding protein 3 | |
| 3552 | IL1A | interleukin 1 alpha | |
| 3554 | IL1R1 | interleukin 1 receptor type 1 | |
| 3557 | IL1RN | interleukin 1 receptor antagonist | |
| 3558 | IL2 | interleukin 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12494 | Cd38 | CD38 antigen | |
| 14103 | Fasl | Fas ligand | |
| 14378 | G6pc2 | glucose-6-phosphatase, catalytic, 2 | |
| 15978 | Ifng | interferon gamma | |
| 15980 | Ifngr2 | interferon gamma receptor 2 | |
| 16177 | Il1r1 | interleukin 1 receptor, type I | |
| 16189 | Il4 | interleukin 4 | |
| 16334 | Ins2 | insulin II | |
| 18609 | Pdx1 | pancreatic and duodenal homeobox 1 | |
| 18646 | Prf1 | perforin 1 (pore forming protein) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24221 | Avp | arginine vasopressin | |
| 24464 | Hp | haptoglobin | |
| 25385 | Faslg | Fas ligand | |
| 25549 | Slc18a2 | solute carrier family 18 member A2 | |
| 25712 | Ifng | interferon gamma | |
| 84349 | Cd40lg | CD40 ligand | |
| 116660 | Ptprn | protein tyrosine phosphatase, receptor type, N |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| O15455 | Toll-like receptor 3 | |
| O60603 | Toll-like receptor 2 | |
| O76024 | Wolframin | |
| O95445 | Apolipoprotein M | |
| P00441 | Superoxide dismutase [Cu-Zn] | |
| P00751 | Complement factor B | |
| P01374 | Lymphotoxin-alpha | |
| P01375 | Tumor necrosis factor | |
| P01583 | Interleukin-1 alpha | |
| P01589 | Interleukin-2 receptor subunit alpha |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01580 | Interferon gamma | |
| P01872 | Immunoglobulin heavy constant mu | |
| P07750 | Interleukin-4 | |
| P10820 | Perforin-1 | |
| P13504 | Interleukin-1 receptor type 1 | |
| P18337 | L-selectin | |
| P41047 | Tumor necrosis factor ligand superfamily member 6 | |
| P43488 | Tumor necrosis factor ligand superfamily member 4 | |
| P52946 | Pancreas/duodenum homeobox protein 1 | |
| P56528 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01186 | Vasopressin-neurophysin 2-copeptin | |
| P01581 | Interferon gamma | |
| P06759 | Apolipoprotein C-III | |
| P06866 | Haptoglobin | |
| P36940 | Tumor necrosis factor ligand superfamily member 6 | |
| Q01827 | Synaptic vesicular amine transporter | |
| Q63259 | Receptor-type tyrosine-protein phosphatase-like N | |
| Q9Z2V2 | CD40 ligand |
