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Guidelines
MIRAGE
insulin like growth factor 1 receptor
Summary
- Gene Symbol
-
- IGF1R
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Cell membrane
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Host-virus interaction
- Isopeptide bond
- Phosphoprotein
- Proteomics identification
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to alkaloid | ||
| negative regulation of MAPK cascade | ||
| positive regulation of MAPK cascade | ||
| phosphatidylinositol 3-kinase/protein kinase B signal transduction | ||
| estrous cycle |
GO Hierarchy
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- immune response
- response to nicotine
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
biological process
metabolic process [inference]
cellular process [inference]
signal transduction
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
cellular response to stimulus [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to hormone stimulus [inference]
cellular response to lipid [inference]
cellular response to organic cyclic compound [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
response to organic substance [inference]
response to hormone [inference]
response to organonitrogen compound [inference]
response to organic cyclic compound [inference]
response to lipid [inference]
cellular response to organic substance [inference]
cellular response to hormone stimulus [inference]
cellular response to lipid [inference]
cellular response to organic cyclic compound [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to hormone stimulus [inference]
cellular response to lipid [inference]
cellular response to organic cyclic compound [inference]
response to nitrogen compound [inference]
response to oxygen-containing compound [inference]
cellular response to stimulus [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to hormone stimulus [inference]
cellular response to lipid [inference]
cellular response to organic cyclic compound [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
signal transduction
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| G-protein alpha-subunit binding | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| GPI-linked ephrin receptor activity |
GO Hierarchy
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- structural molecule activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
binding [inference]
molecular transducer activity [inference]
signaling receptor activity [inference]
transmembrane signaling receptor activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- insulin receptor a
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11476 | osteoporosis | |
| DOID:11695 | portal vein thrombosis | |
| DOID:12217 | Lewy body dementia | |
| DOID:1307 | dementia | |
| DOID:1793 | pancreatic cancer | |
| DOID:2154 | nephroblastoma | |
| DOID:2526 | prostate adenocarcinoma | |
| DOID:2986 | IgA glomerulonephritis | |
| DOID:3070 | high grade glioma | |
| DOID:3602 | toxic encephalopathy |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3480 | Xenbase:XB-GENE-484032 | ||
| 3643 | FB:FBgn0283499 | ||
| 3645 | FB:FBgn0283499 | ||
| 16001 | Xenbase:XB-GENE-484032 | MOUSE52615 | |
| 16337 | FB:FBgn0283499 | ||
| 23920 | FB:FBgn0283499 | ||
| 25718 | Xenbase:XB-GENE-484032 | RATNO18205 | |
| 42549 | Xenbase:XB-GENE-484032 | ||
| 60663 | FB:FBgn0283499 | ||
| 175410 | Xenbase:XB-GENE-484032 |
