PIWI-interacting RNA (piRNA) biogenesis
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- ATP-dependent RNA helicase TDRD9
- Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
- DNA-directed RNA polymerase II subunit RPB11-a
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- Heat shock protein HSP 90-alpha
- Inactive peptidyl-prolyl cis-trans isomerase FKBP6
- Mitochondrial cardiolipin hydrolase
- Myb-related protein A
- Piwi-like protein 1
- Piwi-like protein 2
- Piwi-like protein 4
- Probable ATP-dependent RNA helicase DDX4
- Protein maelstrom homolog
- Putative ATP-dependent RNA helicase TDRD12
- RNA helicase Mov10l1
- Small RNA 2'-O-methyltransferase
- Tudor and KH domain-containing protein
- Tudor domain-containing protein 1
- Tudor domain-containing protein 6
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- ALP1
- AMYB
- ANKL1
- ASZ1
- C14orf75
- C1orf59
- C7orf7
- DDX4
- ECAT8
- FKBP36
- FKBP6
- GASZ
- HENMT1
- HILI
- HIWI
- HIWI2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- MAEL
- MOV10L1
- MYBL1
- PIWI
- PIWIL1
- PIWIL2
- PIWIL4
- PLD6
- POLR2
- POLR2A
- POLR2B
- POLR2C
- POLR2D
- POLR2E
- POLR2F
- POLR2G
- POLR2H
- POLR2I
- POLR2J
- POLR2J1
- POLR2K
- POLR2L
- POLRF
- RPB7
- TDRD1
- TDRD12
- TDRD2
- TDRD6
- TDRD9
- TDRKH
- VASA
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Digestion
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- ALPI
- GUC2C
- GUCA2
- GUCA2A
- GUCA2B
- GUCY2C
- PIR
- STAR
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ALPK1 signaling pathway
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- ALPK1
- KIAA0733
- KIAA1527
- LAK
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- RNF85
- RPS27A
- T2BP
- TAB1
- TAB2
- TAB3
- TAK1
- TIFA
- TRAF6
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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Intra-Golgi traffic
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- ALPP
- ARF1
- ARNO
- ARNO3
- BET1L
- CEV14
- CIP150
- COG1
- COG2
- COG3
- COG4
- COG5
- COG6
- COG7
- COG8
- CUTL1
- CUX1
- CYT4
- CYTH1
- CYTH2
- CYTH3
- CYTH4
- D17S811E
- GIMPC
- GOLGA5
- GOLIM4
- GOLPH4
- GOLTC1
- GOSR1
- GOSR2
- GPP130
- GRP1
- GS15
- GS27
- GS28
- GTC90
- KIAA0258
- KIAA1134
- KIAA1381
- KIAA1432
- LDLB
- LDLC
- MAN1A1
- MAN1A2
- MAN1A3
- MAN1B
- MAN1C
- MAN1C1
- MAN2A1
- MAN2A2
- MANA2
- MANA2X
- NAPA
- NAPB
- NAPG
- NSF
- PLAP
- PSCD1
- PSCD2
- PSCD2L
- PSCD3
- PSCD4
- RAB30
- RAB33B
- RAB36
- RAB39
- RAB39A
- RAB41
- RETII
- RFG5
- RGP1
- RIC1
- SEC34
- SNAP29
- SNAPA
- SNAPB
- SNAPG
- STX16
- STX5
- STX5A
- STX6
- TRIP11
- VPS45
- VPS45A
- VPS45B
- VTI1A
- YKT6
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Formation of the beta-catenin:TCF transactivating complex
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- ALR
- ASH2L
- ASH2L1
- BAF190A
- BCL9
- BCL9L
- BRG1
- C1orf28
- CBP
- CDC73
- CREBBP
- CTNNB
- CTNNB1
- DLNB11
- EP300
- EST2
- GRG4
- H2AB1
- H2AC14
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AFA
- H2AFB1
- H2AFE
- H2AFG
- H2AFJ
- H2AFL
- H2AFM
- H2AFO
- H2AFQ
- H2AFV
- H2AFX
- H2AJ
- H2AV
- H2AX
- H2AZ2
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-3A
- H3-3B
- H3-4
- H3.3A
- H3.3B
- H3C1
- H3C10
- H3C11
- H3C12
- H3C13
- H3C14
- H3C15
- H3C2
- H3C3
- H3C4
- H3C6
- H3C7
- H3C8
- H3F2
- H3F3
- H3F3A
- H3F3B
- H3FA
- H3FB
- H3FC HIST1H3C
- H3FD
- H3FF
- H3FH
- H3FI
- H3FJ
- H3FK
- H3FL
- H3FM
- H3FT
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HDAC1
- HIRIP1
- HIRIP2
- HIST1H2AB
- HIST1H2AC
- HIST1H2AD
- HIST1H2AE
- HIST1H2AJ
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H3A
- HIST1H3B
- HIST1H3D
- HIST1H3E
- HIST1H3F
- HIST1H3G
- HIST1H3H
- HIST1H3I
- HIST1H3J
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2AA
- HIST2H2AA3
- HIST2H2AA4
- HIST2H2AC
- HIST2H2BE
- HIST2H3A
- HIST2H3C
- HIST2H3D
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST3H3
- HIST4H4
- HRPT2
- HTATIP
- INO80H
- KAT5
- KIAA1261
- KIAA1547
- KMT2D
- LEF1
- LEO1
- MEN1
- MLL2
- MLL4
- NMP238
- P300
- PAF400
- PYGO1
- PYGO2
- RBBP5
- RBQ3
- RDL
- RPD3L1
- RUVBL1
- SCG2
- SMARCA4
- SNF2B
- SNF2L4
- TCF1
- TCF3
- TCF4
- TCF7
- TCF7L1
- TCF7L2
- TCS1
- TERT
- TIP49
- TIP49A
- TIP60
- TLE1
- TLE2
- TLE3
- TLE4
- TRRAP
- TRT
- TSH2B
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Energy dependent regulation of mTOR by LKB1-AMPK
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- ALS2CR2
- AMPK
- AMPK1
- AMPK2
- AMPKG3
- C11orf59
- C7orf59
- CAB39
- CAB39L
- FRAP
- FRAP1
- FRAP2
- GBL
- HBXIP
- ILPIP
- KIAA0243
- KIAA1303
- LAMTOR1
- LAMTOR2
- LAMTOR3
- LAMTOR4
- LAMTOR5
- LKB1
- LST8
- LYK5
- MAP2K1IP1
- MAPBPIP
- MAPKSP1
- MLST8
- MO25
- MTOR
- PDRO
- PJS
- PPM1A
- PPPM1A
- PRKAA1
- PRKAA2
- PRKAB1
- PRKAB2
- PRKAG1
- PRKAG2
- PRKAG3
- RAFT1
- RAPT1
- RAPTOR
- RHEB
- RHEB2
- ROBLD3
- RPTOR
- RRAGA
- RRAGB
- RRAGC
- RRAGD
- SLC38A9
- STK11
- STRAD
- STRADA
- STRADB
- TSC
- TSC1
- TSC2
- TSC4
- URLC11
- XIP
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RHOT1 GTPase cycle
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- ALS2CR3
- ARHT1
- KIAA0549
- KIAA1042
- MYO19
- MYOHD1
- OIP106
- RAP1GDS1
- RHOT1
- SMGGDS
- TRAK1
- TRAK2
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RHOT2 GTPase cycle
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- ALS2CR3
- ARHT2
- C16orf39
- CPRP1
- KIAA0214
- KIAA0549
- KIAA1042
- MFN1
- MFN2
- MYO19
- MYOHD1
- OIP106
- RAP1GDS1
- RHOT2
- SMGGDS
- TRAK1
- TRAK2
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RNA Polymerase II Transcription Termination
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- ALY
- ALYREF
- ASF
- BAT1
- BEF
- C1orf77
- C22orf19
- CASC3
- CBP20
- CBP80
- CDC40
- CFIM25
- CHTOP
- CLP1
- COD
- CPSF1
- CPSF100
- CPSF160
- CPSF2
- CPSF25
- CPSF3
- CPSF30
- CPSF4
- CPSF5
- CPSF7
- CPSF73
- CSTF1
- CSTF2
- CSTF2T
- CSTF3
- CXorf3
- DDX38
- DDX39
- DDX39A
- DDX39B
- DDX48
- DHX38
- EHB3
- EIF4A3
- FIP1
- FIP1L1
- FOP
- FYTTD1
- HBP
- HCC1
- HEAB
- HPR1
- HRS
- KIAA0111
- KIAA0224
- KIAA0663
- KIAA0689
- KIAA0824
- KIAA0983
- KIAA1141
- KIAA1367
- KIAA1649
- LDC2
- LSM10
- LSM11
- LUZP4
- MAGOH
- MAGOH2
- MAGOHA
- MAGOHB
- MLN51
- NAR
- NCBP
- NCBP1
- NCBP2
- NEB1
- NIF3L1BP1
- NUDT21
- PAB2
- PABP2
- PABPN1
- PAP
- PAPOLA
- PBSCF
- PBSCG
- PCF11
- PDIP46
- POLDIP3
- PRP16
- PRP17
- PRPF17
- RBM8
- RBM8A
- RENT3B
- RHE
- RNPS1
- SARNP
- SF2
- SF2P33
- SFRS1
- SFRS11
- SFRS2
- SFRS3
- SFRS4
- SFRS5
- SFRS6
- SFRS7
- SFRS9
- SLBP
- SLU7
- SNRPB
- SNRPB1
- SNRPD3
- SNRPE
- SNRPF
- SNRPG
- SPK
- SRM160
- SRP20
- SRP30C
- SRP40
- SRP55
- SRP75
- SRRM1
- SRSF1
- SRSF11
- SRSF2
- SRSF3
- SRSF4
- SRSF5
- SRSF6
- SRSF7
- SRSF9
- SYMPK
- THOC1
- THOC2
- THOC3
- THOC4
- THOC5
- THOC6
- THOC7
- U2AF1
- U2AF1-RS3
- U2AF1L3
- U2AF1L4
- U2AF2
- U2AF35
- U2AF65
- U2AFBP
- UAP56
- UIF
- UPF3B
- UPF3X
- WDC146
- WDR33
- WDR58
- ZC3H11A
- ZC3HDC11A
- ZFP100
- ZNF473
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mRNA 3'-end processing
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- ALY
- ALYREF
- ASF
- BAT1
- BEF
- C1orf77
- C22orf19
- CASC3
- CBP20
- CBP80
- CDC40
- CFIM25
- CHTOP
- CLP1
- CPSF1
- CPSF100
- CPSF160
- CPSF2
- CPSF25
- CPSF3
- CPSF30
- CPSF4
- CPSF5
- CPSF7
- CPSF73
- CSTF1
- CSTF2
- CSTF2T
- CSTF3
- CXorf3
- DDX38
- DDX39
- DDX39A
- DDX39B
- DDX48
- DHX38
- EHB3
- EIF4A3
- FIP1
- FIP1L1
- FOP
- FYTTD1
- HCC1
- HEAB
- HPR1
- HRS
- KIAA0111
- KIAA0224
- KIAA0663
- KIAA0689
- KIAA0824
- KIAA0983
- KIAA1367
- KIAA1649
- LDC2
- LUZP4
- MAGOH
- MAGOH2
- MAGOHA
- MAGOHB
- MLN51
- NAR
- NCBP
- NCBP1
- NCBP2
- NEB1
- NIF3L1BP1
- NUDT21
- PAB2
- PABP2
- PABPN1
- PAP
- PAPOLA
- PCF11
- PDIP46
- POLDIP3
- PRP16
- PRP17
- PRPF17
- RBM8
- RBM8A
- RENT3B
- RHE
- RNPS1
- SARNP
- SF2
- SF2P33
- SFRS1
- SFRS11
- SFRS2
- SFRS3
- SFRS4
- SFRS5
- SFRS6
- SFRS7
- SFRS9
- SLU7
- SPK
- SRM160
- SRP20
- SRP30C
- SRP40
- SRP55
- SRP75
- SRRM1
- SRSF1
- SRSF11
- SRSF2
- SRSF3
- SRSF4
- SRSF5
- SRSF6
- SRSF7
- SRSF9
- SYMPK
- THOC1
- THOC2
- THOC3
- THOC4
- THOC5
- THOC6
- THOC7
- U2AF1
- U2AF1-RS3
- U2AF1L3
- U2AF1L4
- U2AF2
- U2AF35
- U2AF65
- U2AFBP
- UAP56
- UIF
- UPF3B
- UPF3X
- WDC146
- WDR33
- WDR58
- ZC3H11A
- ZC3HDC11A
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Macroautophagy
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- AMBRA1
- AMPK
- AMPK1
- AMPK2
- AMPKG3
- APG10L
- APG12
- APG12L
- APG16L
- APG3
- APG3L
- APG4A
- APG4B
- APG4C
- APG4D
- APG5L
- APG7L
- APG9L1
- APG9L2
- ASP
- ATG10
- ATG101
- ATG12
- ATG13
- ATG14
- ATG14L
- ATG16L1
- ATG3
- ATG4A
- ATG4B
- ATG4C
- ATG4D
- ATG5
- ATG7
- ATG9A
- ATG9B
- AUTL1
- AUTL2
- AUTL3
- AUTL4
- BC2
- BECN1
- C11orf59
- C12orf44
- C14orf123
- C20orf178
- C3orf29
- C7orf59
- CGI149
- CHMP2
- CHMP2A
- CHMP2B
- CHMP3
- CHMP4A
- CHMP4B
- CHMP4C
- CHMP6
- CHMP7
- DCAF3
- DLC1
- DLC2
- DNCL1
- DNCLC1
- DYNLL1
- DYNLL2
- FLC3A
- FLC3B
- FRAP
- FRAP1
- FRAP2
- GABARAP
- GABARAPL1
- GABARAPL2
- GABARAPL3
- GBL
- GEC1
- GEF2
- GT197
- HBXIP
- HDLC1
- KIAA0203
- KIAA0243
- KIAA0371
- KIAA0652
- KIAA0722
- KIAA0831
- KIAA0943
- KIAA1303
- KIAA1736
- LAMTOR1
- LAMTOR2
- LAMTOR3
- LAMTOR4
- LAMTOR5
- LST8
- MAP1ALC3
- MAP1LC3A
- MAP1LC3B
- MAP1LC3C
- MAP2K1IP1
- MAPBPIP
- MAPKSP1
- MLST8
- MTMR14
- MTMR3
- MTOR
- NEDF
- NOS3AS
- PDRO
- PIK3C3
- PIK3R4
- PRKAA1
- PRKAA2
- PRKAB1
- PRKAB2
- PRKAG1
- PRKAG2
- PRKAG3
- RAFT1
- RAPT1
- RAPTOR
- RB1CC1
- RBICC
- RHEB
- RHEB2
- ROBLD3
- RPTOR
- RRAGA
- RRAGB
- RRAGC
- RRAGD
- SHAX1
- SHAX2
- SHAX3
- SLC38A9
- TSC
- TSC1
- TSC2
- TSC4
- ULK1
- URLC11
- UVRAG
- VPS15
- VPS20
- VPS24
- VPS34
- WDR45
- WDR45B
- WDR45L
- WDRX1
- WDRXI4
- WIPI1
- WIPI2
- WIPI3
- WIPI4
- WIPI49
- XIP
- ZFYVE10
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Metabolism of polyamines
|
|
|
- AMD
- AMD1
- ODC1
- SMS
- SPS1
- SRM
- SRML1
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Arachidonic acid metabolism
|
|
|
- AMDD
- AWAT1
- CPLA2
- DGA2
- DGAT2L3
- FAAH
- FAAH1
- FAAH2
- PLA2G4
- PLA2G4A
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Histidine catabolism
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|
|
- AMDHD1
- ATPGD1
- C9orf41
- CARNMT1
- CARNS1
- FTCD
- HAL
- HDC
- HIS
- HNMT
- KIAA1394
- UROC1
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Neddylation
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|
- AMER1
- ANKRD9
- API4
- APPBP1
- ASB1
- ASB10
- ASB11
- ASB12
- ASB13
- ASB14
- ASB15
- ASB16
- ASB17
- ASB18
- ASB2
- ASB3
- ASB4
- ASB5
- ASB6
- ASB7
- ASB8
- ASB9
- BCRG2
- BDPL
- BHLHE17
- BHLHE73
- BHLHE78
- BIG3
- BIRC5
- BKLHD2
- BRCA1
- BTBD1
- BTBD6
- BTRC
- BTRCP
- BTRCP2
- BUP
- C10orf8
- C13orf17
- C15orf1
- C16orf22
- C16orf31
- C19orf58
- C1orf166
- C20orf163
- C20orf92
- C2orf37
- C2orf5
- C4orf30
- C7orf76
- CAND1
- CAP20
- CCDC22
- CCDC8
- CCNF
- CDKN1
- CDKN1A
- CDT2
- CDW1
- CIP1
- CIS2
- CIS3
- CIS4
- CIS6
- CISH
- CISH5
- CISH6
- CKN1
- COMMD1
- COMMD10
- COMMD2
- COMMD3
- COMMD4
- COMMD5
- COMMD6
- COMMD7
- COMMD8
- COMMD9
- COP1
- COPS1
- COPS2
- COPS3
- COPS4
- COPS5
- COPS6
- COPS7A
- COPS7B
- COPS8
- CSA
- CSN1
- CSN2
- CSN3
- CSN4
- CSN5
- CSN6
- CSN7A
- CSN7B
- CSN8
- CUL1
- CUL2
- CUL3
- CUL4A
- CUL4B
- CUL5
- CUL7
- CUL9
- CXorf37
- DCAF10
- DCAF11
- DCAF13
- DCAF16
- DCAF17
- DCAF2
- DCAF4
- DCAF5
- DCAF6
- DCAF7
- DCAF8
- DCN1
- DCUN1D1
- DCUN1D2
- DCUN1D3
- DCUN1D4
- DCUN1D5
- DCUN1L1
- DCUN1L2
- DDA1
- DDB1
- DDB2
- DEN1
- DERP10
- DPP3
- DRC6
- DSS1
- DTL
- ELOB
- ELOC
- EMC19
- ENC2
- EPAS1
- EPRAP
- ERCC8
- F1AA
- FAM123B
- FANCN
- FAT10
- FBG2
- FBG3
- FBG4
- FBG5
- FBL12
- FBL13
- FBL14
- FBL16
- FBL18
- FBL19
- FBL2
- FBL21
- FBL3
- FBL3A
- FBL4
- FBL5
- FBL6
- FBL7
- FBL8
- FBS2
- FBW12
- FBW1A
- FBW1B
- FBW2
- FBW4
- FBW5
- FBW6
- FBW7
- FBW8
- FBW9
- FBX1
- FBX10
- FBX11
- FBX14
- FBX15
- FBX17
- FBX2
- FBX20
- FBX21
- FBX22
- FBX26
- FBX27
- FBX29
- FBX30
- FBX31
- FBX4
- FBX40
- FBX41
- FBX44
- FBX6
- FBX6A
- FBX7
- FBX9
- FBXL1
- FBXL12
- FBXL13
- FBXL14
- FBXL15
- FBXL16
- FBXL18
- FBXL19
- FBXL20
- FBXL21
- FBXL21P
- FBXL22
- FBXL3
- FBXL3A
- FBXL3B
- FBXL3P
- FBXL4
- FBXL5
- FBXL7
- FBXL8
- FBXO1
- FBXO10
- FBXO11
- FBXO12
- FBXO15
- FBXO17
- FBXO2
- FBXO20
- FBXO21
- FBXO22
- FBXO26
- FBXO27
- FBXO29
- FBXO30
- FBXO31
- FBXO32
- FBXO35
- FBXO37
- FBXO4
- FBXO40
- FBXO41
- FBXO44
- FBXO6
- FBXO6A
- FBXO7
- FBXO9
- FBXW10
- FBXW11
- FBXW12
- FBXW1A
- FBXW1B
- FBXW2
- FBXW4
- FBXW5
- FBXW6
- FBXW7
- FBXW8
- FBXW9
- FEM1A
- FEM1B
- FEM1C
- FLR1
- FWD2
- G18
- GAN
- GAN1
- GIDE
- GPS1
- GRCC9
- H326
- H7AP1
- HAN11
- HC2
- HC3
- HC8
- HC9
- HEL-220
- HEL-S-70
- HIF1A
- HIF2A
- HIF3A
- HSPC
- HVIP
- IAP4
- IFI5111
- INRF2
- IQWD1
- JAB1
- KBTBD10
- KBTBD13
- KBTBD6
- KBTBD7
- KBTBD8
- KCTD6
- KCTD7
- KEAP1
- KIAA0072
- KIAA0076
- KIAA0077
- KIAA0107
- KIAA0132
- KIAA0235
- KIAA0276
- KIAA0396
- KIAA0469
- KIAA0617
- KIAA0657
- KIAA0671
- KIAA0695
- KIAA0696
- KIAA0708
- KIAA0794
- KIAA0829
- KIAA0840
- KIAA0858
- KIAA0875
- KIAA1037
- KIAA1129
- KIAA1146
- KIAA1195
- KIAA1309
- KIAA1340
- KIAA1354
- KIAA1397
- KIAA1499
- KIAA1785
- KIAA1824
- KIAA1842
- KIAA1940
- KLEIP
- KLHDC5
- KLHL11
- KLHL13
- KLHL16
- KLHL19
- KLHL2
- KLHL20
- KLHL21
- KLHL22
- KLHL25
- KLHL3
- KLHL41
- KLHL42
- KLHL5
- KLHL9
- KLHLX
- KRP1
- L2DTL
- LMO7
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- LRR1
- LRRC41
- MAPL
- MB1
- MCB1
- MDA6
- MECL1
- MIP224
- MOP1
- MOP2
- MOP7
- MOV34L
- MSS1
- MUF1
- MUL1
- MULAN
- MURR1
- NAE1
- NCE2
- NEDD8
- NEDP1
- NEURL2
- NFE2L2
- NPL4
- NPLOC4
- NRF2
- NS5ATP8
- NU
- OBSL1
- OCP2
- ORCA
- OSIL
- PALB2
- PARC
- PASD2
- PASD7
- PASD8
- PCIA1
- PFAAP4
- PIC1
- PLZF
- POH1
- PPIL5
- PRMT11
- PRMT9
- PROS26
- PROS27
- PROS30
- PRSC2
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- PUBC1
- PUM2
- PUMH2
- RAMP
- RBAP46
- RBBP5
- RBBP7
- RBQ3
- RBX1
- RBX2
- RFWD2
- RING10
- RING12
- RNF200
- RNF218
- RNF53
- RNF7
- RNF75
- ROC1
- ROC2
- RP42
- RPS27A
- SAG
- SCCRO
- SCCRO3
- SCCRO5
- SDI1
- SEL10
- SEM1
- SENP8
- SFT
- SHFDG1
- SHFM1
- SHFM3
- SKP1
- SKP1A
- SKP2
- SOCS2
- SOCS3
- SOCS4
- SOCS5
- SOCS6
- SPSB1
- SPSB2
- SPSB3
- SPSB4
- SQSTM1
- SSB1
- SSB2
- SSB3
- SSB4
- SSI2
- SSI3
- STATI2
- SUG1
- SUG2
- SWIP1
- TAKRP
- TBP1
- TBP7
- TCEB1
- TCEB1L
- TCEB2
- TIP120
- TIP120A
- TRAP2
- TRIP15
- TUBL4
- TULP4
- TUSP
- UBA3
- UBA52
- UBA80
- UBB
- UBC
- UBC12
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBD
- UBE1C
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2F
- UBE2M
- UBXD7
- UBXN7
- UCHL3
- UFD1
- UFD1L
- VACM1
- VCIA1
- VCP
- VHL
- VIT1
- WAF1
- WDR21
- WDR21A
- WDR22
- WDR23
- WDR32
- WDR42A
- WDR5
- WDR68
- WDSOF1
- WDTC1
- WSB1
- WSB2
- WTX
- X
- XAP1
- Y
- Y2
- Z
- ZBTB16
- ZNF145
- x
|
|
Degradation of beta-catenin by the destruction complex
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- BTRC
- BTRCP
- C7orf76
- CSNK1A1
- CTNNB
- CTNNB1
- CUL1
- DP2.5
- DSS1
- EMC19
- FAM123B
- FBW1A
- FBXW1A
- GSK3B
- HC2
- HC3
- HC8
- HC9
- HSPC
- IFI5111
- KIAA0044
- KIAA0072
- KIAA0077
- KIAA0107
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MB1
- MCB1
- MECL1
- MIP224
- MOV34L
- MSS1
- NU
- OCP2
- PFAAP4
- POH1
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- RBX1
- RING10
- RING12
- RNF75
- ROC1
- RPS27A
- SEM1
- SHFDG1
- SHFM1
- SKP1
- SKP1A
- SUG1
- SUG2
- TBP1
- TBP7
- TCEB1L
- TRABID
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WTX
- X
- Y
- Y2
- Z
- ZRANB1
|
|
Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- C2orf31
- CAV
- CAV1
- CK1G2
- CSNK1A1
- CSNK1G2
- CTNNB
- CTNNB1
- DP2.5
- DVL1
- DVL2
- DVL3
- FAM123B
- FRAT1
- FRAT2
- FZD1
- FZD2
- FZD5
- GSK3B
- INT1
- KIAA0044
- KIAA0208
- LR3
- LRP5
- LRP6
- LRP7
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WNT1
- WNT3A
- WNT8A
- WNT8B
- WNT8D
- WTX
|
|
Beta-catenin phosphorylation cascade
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- FRAT1
- FRAT2
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
CTNNB1 T41 mutants aren't phosphorylated
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
Signaling by GSK3beta mutants
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
CTNNB1 S45 mutants aren't phosphorylated
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
CTNNB1 S33 mutants aren't phosphorylated
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
CTNNB1 S37 mutants aren't phosphorylated
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- CTNNB
- CTNNB1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
AXIN missense mutants destabilize the destruction complex
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|
APC truncation mutants have impaired AXIN binding
|
|
|
- AMER1
- APC
- AXIN
- AXIN1
- CSNK1A1
- DP2.5
- FAM123B
- GSK3B
- KIAA0044
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- WTX
|
|