Homo sapiens (human)

Summary
Taxonomy ID
9606
PubChem Taxonomy
9606
Displaying entries 1326 - 1350 of 2090 in total
Pathway Name Protein Name UniProt ID Gene Symbol ▼ GlyTouCan ID
Binding of TCF/LEF:CTNNB1 to target gene promoters
  • AML2
  • AXIN2
  • BHLHE39
  • CBFA3
  • CTNNB
  • CTNNB1
  • LEF1
  • MYC
  • PEBP2A3
  • RUNX3
  • TCF1
  • TCF3
  • TCF4
  • TCF7
  • TCF7L1
  • TCF7L2
RUNX3 regulates CDKN1A transcription
  • AML2
  • ATBF1
  • C16orf47
  • CAP20
  • CBFA3
  • CDKN1
  • CDKN1A
  • CIP1
  • DPC4
  • MADH3
  • MADH4
  • MDA6
  • P53
  • PEBP2A3
  • PIC1
  • RUNX3
  • SDI1
  • SMAD3
  • SMAD4
  • TGFB
  • TGFB1
  • TP53
  • WAF1
  • ZFHX3
RUNX2 regulates genes involved in differentiation of myeloid cells
  • AML1
  • CBFA2
  • CBFB
  • LGALS3
  • MAC2
  • RUNX1
RUNX1 regulates transcription of genes involved in interleukin signaling
  • AML1
  • CBFA2
  • CBFB
  • ELF1
  • IL3
  • LIFR
  • RUNX1
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
  • AML1
  • CBFA2
  • CBFB
  • CBP
  • CREBBP
  • CSF2
  • GMCSF
  • LGALS3
  • MAC2
  • PKCB
  • PRKCB
  • PRKCB1
  • RUNX1
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
  • AML1
  • CATL2
  • CBFA2
  • CBFB
  • CIS3
  • CTSK
  • CTSL
  • CTSL1
  • CTSL2
  • CTSO
  • CTSO2
  • CTSU
  • CTSV
  • PI13
  • RUNX1
  • SERPINB13
  • SOCS3
  • SOCS4
  • SOCS7
  • SSI3
Organic cation transport
  • AML1
  • BWR1A
  • BWSCR1A
  • CBFA2
  • EMTH
  • ETT
  • FLIPT1
  • HET
  • IMPT1
  • ITM
  • OCT1
  • OCT2
  • OCT3
  • OCT6
  • OCTN1
  • OCTN2
  • ORCTL2
  • RSC1A1
  • RUNX1
  • SLC22A1
  • SLC22A15
  • SLC22A16
  • SLC22A18
  • SLC22A1L
  • SLC22A2
  • SLC22A3
  • SLC22A4
  • SLC22A5
  • TSSC5
  • UT2H
RUNX1 regulates transcription of genes involved in BCR signaling
  • AML1
  • BLK
  • CBFA2
  • CBFB
  • ELF1
  • ELF2
  • NERF
  • PAX5
  • RUNX1
RUNX1 regulates estrogen receptor mediated transcription
  • AML1
  • AXIN
  • AXIN1
  • CBFA2
  • CBFB
  • ESR
  • ESR1
  • GPAM
  • GPAT1
  • KCTD6
  • KIAA1560
  • NR3A1
  • RUNX1
RUNX1 regulates transcription of genes involved in WNT signaling
  • AML1
  • AXIN
  • AXIN1
  • CBFA2
  • CBFB
  • ESR
  • ESR1
  • FOXP3
  • IPEX
  • NR3A1
  • PWTSR
  • RSPO3
  • RUNX1
  • THSD2
RUNX1 regulates expression of components of tight junctions
  • AML1
  • AWAL
  • CBFA2
  • CBFB
  • CLDN5
  • OCLN
  • RUNX1
  • TJP1
  • TMVCF
  • ZO1
RUNX3 regulates p14-ARF
  • AML1
  • AML2
  • BCL1
  • BRD2
  • CBFA2
  • CBFA3
  • CBFB
  • CCND1
  • EP300
  • HDAC4
  • KIAA0288
  • KIAA9001
  • KRAS
  • KRAS2
  • P300
  • PEBP2A3
  • PRAD1
  • RASK2
  • RING3
  • RUNX1
  • RUNX3
  • TGFB
  • TGFB1
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
  • AMFR
  • DER1
  • DERL1
  • ENGASE
  • G19P1
  • G2AN
  • GANAB
  • GCS1
  • HEL-220
  • HEL-S-70
  • KIAA0088
  • KIAA0152
  • MLEC
  • MOGS
  • NGLY1
  • PNG1
  • PRKCSH
  • PSMC1
  • RAD23B
  • RNF45
  • RPS27A
  • SAKS1
  • UBA52
  • UBA80
  • UBB
  • UBC
  • UBCEP1
  • UBCEP2
  • UBXN1
  • VCP
ER Quality Control Compartment (ERQC)
  • AMFR
  • C1orf22
  • C20orf31
  • C20orf49
  • DER2
  • DERL2
  • EDEM
  • EDEM1
  • EDEM2
  • EDEM3
  • FLANA
  • G16
  • GT
  • HRD1
  • KIAA0212
  • KIAA0597
  • KIAA1810
  • LEU5
  • MAN1B1
  • MARCH6
  • MARCHF6
  • NG2
  • OS9
  • RFP2
  • RMA1
  • RNF103
  • RNF139
  • RNF176
  • RNF185
  • RNF45
  • RNF5
  • RNF77
  • RPS27A
  • SEL1L
  • SYVN1
  • TEB4
  • TRC8
  • TRIM13
  • TSA305
  • UBA52
  • UBA80
  • UBB
  • UBC
  • UBCEP1
  • UBCEP2
  • UGCGL1
  • UGCGL2
  • UGGT
  • UGGT1
  • UGGT2
  • UGT1
  • UGT2
  • UGTR
  • ZFP103
AXIN missense mutants destabilize the destruction complex
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
APC truncation mutants have impaired AXIN binding
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
Truncations of AMER1 destabilize the destruction complex
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
CTNNB1 T41 mutants aren't phosphorylated
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
Signaling by GSK3beta mutants
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
CTNNB1 S45 mutants aren't phosphorylated
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
CTNNB1 S33 mutants aren't phosphorylated
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
CTNNB1 S37 mutants aren't phosphorylated
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
Beta-catenin phosphorylation cascade
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • DP2.5
  • FAM123B
  • FRAT1
  • FRAT2
  • GSK3B
  • KIAA0044
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WTX
Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • C2orf31
  • CAV
  • CAV1
  • CK1G2
  • CSNK1A1
  • CSNK1G2
  • CTNNB
  • CTNNB1
  • DP2.5
  • DVL1
  • DVL2
  • DVL3
  • FAM123B
  • FRAT1
  • FRAT2
  • FZD1
  • FZD2
  • FZD5
  • GSK3B
  • INT1
  • KIAA0044
  • KIAA0208
  • LR3
  • LRP5
  • LRP6
  • LRP7
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • WNT1
  • WNT3A
  • WNT8A
  • WNT8B
  • WNT8D
  • WTX
Degradation of beta-catenin by the destruction complex
  • AMER1
  • APC
  • AXIN
  • AXIN1
  • BTRC
  • BTRCP
  • C7orf76
  • CSNK1A1
  • CTNNB
  • CTNNB1
  • CUL1
  • DP2.5
  • DSS1
  • EMC19
  • FAM123B
  • FBW1A
  • FBXW1A
  • GSK3B
  • HC2
  • HC3
  • HC8
  • HC9
  • HSPC
  • IFI5111
  • KIAA0044
  • KIAA0072
  • KIAA0077
  • KIAA0107
  • LMP10
  • LMP2
  • LMP7
  • LMPX
  • LMPY
  • MB1
  • MCB1
  • MECL1
  • MIP224
  • MOV34L
  • MSS1
  • NU
  • OCP2
  • PFAAP4
  • POH1
  • PPP2CA
  • PPP2CB
  • PPP2R1A
  • PPP2R1B
  • PPP2R5A
  • PPP2R5B
  • PPP2R5C
  • PPP2R5D
  • PPP2R5E
  • PROS26
  • PROS27
  • PROS30
  • PSC2
  • PSC3
  • PSC5
  • PSC8
  • PSC9
  • PSMA1
  • PSMA2
  • PSMA3
  • PSMA4
  • PSMA5
  • PSMA6
  • PSMA7
  • PSMA7L
  • PSMA8
  • PSMB1
  • PSMB10
  • PSMB11
  • PSMB2
  • PSMB3
  • PSMB4
  • PSMB5
  • PSMB5i
  • PSMB6
  • PSMB6i
  • PSMB7
  • PSMB8
  • PSMB9
  • PSMC1
  • PSMC2
  • PSMC3
  • PSMC4
  • PSMC5
  • PSMC6
  • PSMD1
  • PSMD10
  • PSMD11
  • PSMD12
  • PSMD13
  • PSMD14
  • PSMD2
  • PSMD3
  • PSMD4
  • PSMD5
  • PSMD6
  • PSMD7
  • PSMD8
  • PSMD9
  • PSME1
  • PSME2
  • PSME3
  • PSME4
  • PSMF1
  • RBX1
  • RING10
  • RING12
  • RNF75
  • ROC1
  • RPS27A
  • SEM1
  • SHFDG1
  • SHFM1
  • SKP1
  • SKP1A
  • SUG1
  • SUG2
  • TBP1
  • TBP7
  • TCEB1L
  • TRABID
  • TRAP2
  • UBA52
  • UBA80
  • UBB
  • UBC
  • UBCEP1
  • UBCEP2
  • WTX
  • X
  • Y
  • Y2
  • Z
  • ZRANB1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024