chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 71 - 80 of 126 in total
Gene ID Gene Symbol Description Source
4089 SMAD4 SMAD family member 4
4153 MBL2 mannose binding lectin 2
4162 MCAM melanoma cell adhesion molecule
4312 MMP1 matrix metallopeptidase 1
4318 MMP9 matrix metallopeptidase 9
4353 MPO myeloperoxidase
4363 ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group)
4582 MUC1 mucin 1, cell surface associated
4586 MUC5AC mucin 5AC, oligomeric mucus/gel-forming
4780 NFE2L2 NFE2 like bZIP transcription factor 2
Displaying entries 21 - 30 of 123 in total
Gene ID Gene Symbol Description Source
12774 Ccr5 C-C motif chemokine receptor 5
12842 Col1a1 collagen, type I, alpha 1
12921 Crhr1 corticotropin releasing hormone receptor 1
12981 Csf2 colony stimulating factor 2 (granulocyte-macrophage)
13076 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
13077 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
13649 Egfr epidermal growth factor receptor
13653 Egr1 early growth response 1
13849 Ephx1 epoxide hydrolase 1, microsomal
13867 Erbb3 erb-b2 receptor tyrosine kinase 3
Displaying entries 1 - 10 of 68 in total
Gene ID Gene Symbol Description Source
24232 C3 complement C3
24255 Cftr CF transmembrane conductance regulator
24260 Chrm3 cholinergic receptor, muscarinic 3
24296 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
24297 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
24310 Ace angiotensin I converting enzyme
24407 Grik5 glutamate ionotropic receptor kainate type subunit 5
24410 Grin2b glutamate ionotropic receptor NMDA type subunit 2B
24464 Hp haptoglobin
24536 Lepr leptin receptor
Displaying entry 21 - 21 of 21 in total
Gene ID Gene Symbol Description Source
43222 Tl Toll
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 33 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
172449 glr-3 Glutamate receptor ionotropic, kainate glr-3
174262 acr-7 Acetylcholine receptor subunit alpha-type acr-7
174462 let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
175072 eat-2 Neuronal acetylcholine receptor subunit eat-2
175182 ver-1 Protein ver-1
175383 zmp-2 Matrix metalloproteinase-B
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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