chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 21 - 30 of 126 in total
Gene ID Gene Symbol Description Source
1139 CHRNA7 cholinergic receptor nicotinic alpha 7 subunit
1179 CLCA1 chloride channel accessory 1
1215 CMA1 chymase 1
1232 CCR3 C-C motif chemokine receptor 3
1234 CCR5 C-C motif chemokine receptor 5
1277 COL1A1 collagen type I alpha 1 chain
1394 CRHR1 corticotropin releasing hormone receptor 1
1437 CSF2 colony stimulating factor 2
1490 CCN2 cellular communication network factor 2
1493 CTLA4 cytotoxic T-lymphocyte associated protein 4
Displaying entries 111 - 120 of 123 in total
Gene ID Gene Symbol Description Source
72393 Faim2 Fas apoptotic inhibitory molecule 2
74069 Serpina3a serine (or cysteine) peptidase inhibitor, clade A, member 3A
74180 Muc5b mucin 5, subtype B, tracheobronchial
83995 Mmp1a matrix metallopeptidase 1a (interstitial collagenase)
84004 Mcam melanoma cell adhesion molecule
94217 Lrp1b low density lipoprotein-related protein 1B
110751 Adam33 a disintegrin and metallopeptidase domain 33
110834 Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3
110835 Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5
238393 Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F
Displaying entries 1 - 10 of 68 in total
Gene ID Gene Symbol Description Source
24232 C3 complement C3
24255 Cftr CF transmembrane conductance regulator
24260 Chrm3 cholinergic receptor, muscarinic 3
24296 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
24297 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
24310 Ace angiotensin I converting enzyme
24407 Grik5 glutamate ionotropic receptor kainate type subunit 5
24410 Grin2b glutamate ionotropic receptor NMDA type subunit 2B
24464 Hp haptoglobin
24536 Lepr leptin receptor
Displaying entries 1 - 10 of 21 in total
Gene ID Gene Symbol Description Source
31926 Idgf4 Imaginal disc growth factor 4
34091 Spn28Dc Serpin 28Dc
34189 Acer Angiotensin-converting enzyme-related
34304 nAChRalpha6 nicotinic Acetylcholine Receptor alpha6
34805 Ance Angiotensin converting enzyme
34978 Idgf1 Imaginal disc growth factor 1
34979 Idgf2 Imaginal disc growth factor 2
34981 Idgf3 Imaginal disc growth factor 3
36868 Idgf6 Imaginal disc growth factor 6
37104 Idgf5 Imaginal disc growth factor 5
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 33 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
172449 glr-3 Glutamate receptor ionotropic, kainate glr-3
174262 acr-7 Acetylcholine receptor subunit alpha-type acr-7
174462 let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
175072 eat-2 Neuronal acetylcholine receptor subunit eat-2
175182 ver-1 Protein ver-1
175383 zmp-2 Matrix metalloproteinase-B
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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