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type 1 diabetes mellitus
Summary
- Synonym
-
- IDDM
- insulin-dependent diabetes mellitus
- type I diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
- Super Class
- autoimmune disease of endocrine system diabetes mellitus
External Links
- Disease Ontology
- DOID:9744
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
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Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 1056 | CEL | carboxyl ester lipase | |
| 1493 | CTLA4 | cytotoxic T-lymphocyte associated protein 4 | |
| 1594 | CYP27B1 | cytochrome P450 family 27 subfamily B member 1 | |
| 1636 | ACE | angiotensin I converting enzyme | |
| 2155 | F7 | coagulation factor VII | |
| 2572 | GAD2 | glutamate decarboxylase 2 | |
| 2638 | GC | GC vitamin D binding protein | |
| 3113 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | |
| 3115 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | |
| 3117 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24221 | Avp | arginine vasopressin | |
| 24464 | Hp | haptoglobin | |
| 25385 | Faslg | Fas ligand | |
| 25549 | Slc18a2 | solute carrier family 18 member A2 | |
| 25712 | Ifng | interferon gamma | |
| 84349 | Cd40lg | CD40 ligand | |
| 116660 | Ptprn | protein tyrosine phosphatase, receptor type, N |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P05362 | Intercellular adhesion molecule 1 | |
| P05451 | Lithostathine-1-alpha | |
| P06276 | Cholinesterase | |
| P08709 | Coagulation factor VII | |
| P10747 | T-cell-specific surface glycoprotein CD28 | |
| P11717 | Cation-independent mannose-6-phosphate receptor | |
| P12821 | Angiotensin-converting enzyme | |
| P13501 | C-C motif chemokine 5 | |
| P14778 | Interleukin-1 receptor type 1 | |
| P16410 | Cytotoxic T-lymphocyte protein 4 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01580 | Interferon gamma | |
| P01872 | Immunoglobulin heavy constant mu | |
| P07750 | Interleukin-4 | |
| P10820 | Perforin-1 | |
| P13504 | Interleukin-1 receptor type 1 | |
| P18337 | L-selectin | |
| P41047 | Tumor necrosis factor ligand superfamily member 6 | |
| P43488 | Tumor necrosis factor ligand superfamily member 4 | |
| P52946 | Pancreas/duodenum homeobox protein 1 | |
| P56528 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01186 | Vasopressin-neurophysin 2-copeptin | |
| P01581 | Interferon gamma | |
| P06759 | Apolipoprotein C-III | |
| P06866 | Haptoglobin | |
| P36940 | Tumor necrosis factor ligand superfamily member 6 | |
| Q01827 | Synaptic vesicular amine transporter | |
| Q63259 | Receptor-type tyrosine-protein phosphatase-like N | |
| Q9Z2V2 | CD40 ligand |
