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Standards Ontologies Notations
Guidelines
MIRAGE
obesity

Summary
Definition
An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Super Class
overnutrition
Disease Ontology
DOID:9970
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
12876 Cpe carboxypeptidase E
14738 Gpr12 G-protein coupled receptor 12
14917 Gucy2c guanylate cyclase 2c
16846 Lep leptin
16847 Lepr leptin receptor
17201 Mc3r melanocortin 3 receptor
17202 Mc4r melanocortin 4 receptor
17977 Ncoa1 nuclear receptor coactivator 1
18166 Npy1r neuropeptide Y receptor Y1
18548 Pcsk1 proprotein convertase subtilisin/kexin type 1
Displaying entries 21 - 25 of 25 in total
Gene ID Gene Symbol Description Source
85268 Hrh3 histamine receptor H3
113959 C5ar1 complement C5a receptor 1
171374 Atp5f1b ATP synthase F1 subunit beta
245965 Atp5f1d ATP synthase F1 subunit delta
246075 Prlhr prolactin releasing hormone receptor
Displaying all 3 entries
Gene ID Gene Symbol Description Source
173169 eif-6 Eukaryotic translation initiation factor 6
176286 glp-1 glp-1/Notch intracellular domain
177850 gon-1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein
Related Glycoprotein
The Human Phenotype Ontology
Displaying all 5 entries
HPO ID HPO Term
HP:0010982 Polygenic inheritance
HP:0012340 Decreased resting energy expenditure
HP:0001513 Obesity
HP:0000007 Autosomal recessive inheritance
HP:0000006 Autosomal dominant inheritance
Displaying all 2 entries
Gene ID Gene Symbol Description
9672 SDC3 syndecan 3
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025