chronic obstructive pulmonary disease

Summary
Synonym
  • COLD
  • COPD
  • chronic obstructive airway disease
  • chronic obstructive lung disease
Definition
An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
Super Class
obstructive lung disease
Disease Ontology
DOID:3083
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying entries 111 - 120 of 126 in total
Gene ID Gene Symbol Description Source
7422 VEGFA vascular endothelial growth factor A
7520 XRCC5 X-ray repair cross complementing 5
8754 ADAM9 ADAM metallopeptidase domain 9
9173 IL1RL1 interleukin 1 receptor like 1
9370 ADIPOQ adiponectin, C1Q and collagen domain containing
10068 IL18BP interleukin 18 binding protein
10891 PPARGC1A PPARG coactivator 1 alpha
23017 FAIM2 Fas apoptotic inhibitory molecule 2
25805 BAMBI BMP and activin membrane bound inhibitor
53353 LRP1B LDL receptor related protein 1B
Displaying entries 81 - 90 of 123 in total
Gene ID Gene Symbol Description Source
18979 Pon1 paraoxonase 1
19017 Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
19225 Ptgs2 prostaglandin-endoperoxide synthase 2
20290 Ccl1 C-C motif chemokine ligand 1
20292 Ccl11 C-C motif chemokine ligand 11
20296 Ccl2 C-C motif chemokine ligand 2
20306 Ccl7 C-C motif chemokine ligand 7
20344 Selp selectin, platelet
20388 Sftpb surfactant associated protein B
20390 Sftpd surfactant associated protein D
Displaying entries 1 - 10 of 68 in total
Gene ID Gene Symbol Description Source
24232 C3 complement C3
24255 Cftr CF transmembrane conductance regulator
24260 Chrm3 cholinergic receptor, muscarinic 3
24296 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
24297 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
24310 Ace angiotensin I converting enzyme
24407 Grik5 glutamate ionotropic receptor kainate type subunit 5
24410 Grin2b glutamate ionotropic receptor NMDA type subunit 2B
24464 Hp haptoglobin
24536 Lepr leptin receptor
Displaying entries 11 - 20 of 21 in total
Gene ID Gene Symbol Description Source
37455 Egfr Epidermal growth factor receptor
37892 mAChR-A muscarinic Acetylcholine Receptor, A-type
37895 SerT Serotonin transporter
38326 Pxn Peroxidasin
38545 nAChRbeta1 nicotinic Acetylcholine Receptor beta1
39557 Hsp110 Heat shock protein 110
41549 Octbeta2R Octopamine beta2 receptor
42918 nAChRalpha1 nicotinic Acetylcholine Receptor alpha1
42919 nAChRalpha2 nicotinic Acetylcholine Receptor alpha2
42920 nAChRbeta2 nicotinic Acetylcholine Receptor beta2
Displaying all 6 entries
Gene ID Gene Symbol Description Source
30682 vegfaa vascular endothelial growth factor Aa
447803 pon1 paraoxonase 1
554230 kdr kinase insert domain receptor (a type III receptor tyrosine kinase)
559080 cftr CF transmembrane conductance regulator
565980 ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
791973 cxcr3.2 chemokine (C-X-C motif) receptor 3, tandem duplicate 2
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
373580 crhr1.2.S corticotropin releasing hormone receptor 1, gene 2 S homeolog Xenopus laevis (African clawed frog)
397778 tgfb1.L transforming growth factor beta 1 L homeolog Xenopus laevis (African clawed frog)
399298 ntf3.L neurotrophin 3 L homeolog Xenopus laevis (African clawed frog)
448598 pon2 paraoxonase 2 Xenopus tropicalis (tropical clawed frog)
100144634 ace angiotensin I converting enzyme Xenopus tropicalis (tropical clawed frog)
108697308 adrb1.L adrenoceptor beta 1 L homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 33 in total
Gene ID Gene Symbol Description Source
171999 poml-2 Arylesterase
172105 unc-38 Acetylcholine receptor subunit alpha-type unc-38
172150 unc-63 Acetylcholine receptor subunit alpha-type unc-63
172449 glr-3 Glutamate receptor ionotropic, kainate glr-3
174262 acr-7 Acetylcholine receptor subunit alpha-type acr-7
174462 let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
175072 eat-2 Neuronal acetylcholine receptor subunit eat-2
175182 ver-1 Protein ver-1
175383 zmp-2 Matrix metalloproteinase-B
177343 skn-1 BZIP domain-containing protein;Protein skinhead-1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
851977 CTS2 putative chitinase
853313 PBS2 mitogen-activated protein kinase kinase PBS2
853978 NFT1 putative multidrug transporter NFT1

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