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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 19 | ABCA1 | ATP binding cassette subfamily A member 1 | |
| 111 | ADCY5 | adenylate cyclase 5 | |
| 133 | ADM | adrenomedullin | |
| 142 | PARP1 | poly(ADP-ribose) polymerase 1 | |
| 150 | ADRA2A | adrenoceptor alpha 2A | |
| 154 | ADRB2 | adrenoceptor beta 2 | |
| 155 | ADRB3 | adrenoceptor beta 3 | |
| 177 | AGER | advanced glycosylation end-product specific receptor | |
| 183 | AGT | angiotensinogen | |
| 186 | AGTR2 | angiotensin II receptor type 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24053 | Sgcg | sarcoglycan, gamma (dystrophin-associated glycoprotein) | |
| 26357 | Abcg2 | ATP binding cassette subfamily G member 2 (Junior blood group) | |
| 26362 | Axl | AXL receptor tyrosine kinase | |
| 26383 | Fto | FTO alpha-ketoglutarate dependent dioxygenase | |
| 27226 | Pla2g7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | |
| 30930 | Vps26a | VPS26 retromer complex component A | |
| 50518 | a | nonagouti | |
| 53322 | Nucb2 | nucleobindin 2 | |
| 53412 | Ppp1r3c | protein phosphatase 1, regulatory subunit 3C | |
| 56373 | Cpb2 | carboxypeptidase B2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24651 | Pklr | pyruvate kinase L/R | |
| 24668 | Ppp1ca | protein phosphatase 1 catalytic subunit alpha | |
| 24669 | Ppp1cc | protein phosphatase 1 catalytic subunit gamma | |
| 24770 | Ccl2 | C-C motif chemokine ligand 2 | |
| 24775 | Shbg | sex hormone binding globulin | |
| 24778 | Slc2a1 | solute carrier family 2 member 1 | |
| 24787 | Sod2 | superoxide dismutase 2 | |
| 24835 | Tnf | tumor necrosis factor | |
| 24861 | Ugt1a1 | UDP glucuronosyltransferase family 1 member A1 | |
| 24889 | Cckar | cholecystokinin A receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31234 | Pdfr | Pigment-dispersing factor receptor | |
| 31248 | sgg | shaggy | |
| 31271 | w | white | |
| 31806 | Ogg1 | 8-oxoguanine DNA glycosylase | |
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 32442 | Rab3-GEF | Rab3 GDP-GTP exchange factor | |
| 32974 | Zw | Zwischenferment | |
| 33007 | Dop2R | Dopamine 2-like receptor | |
| 33496 | lilli | lilliputian | |
| 34091 | Spn28Dc | Serpin 28Dc |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30173 | nog3 | noggin 3 | |
| 30174 | nog1 | noggin 1 | |
| 30262 | ins | preproinsulin | |
| 30667 | mtnr1aa | melatonin receptor 1A a | |
| 30668 | mtnr1bb | melatonin receptor 1Bb | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 321664 | aldob | aldolase b, fructose-bisphosphate | |
| 337685 | ogt.1 | O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 | |
| 393807 | ppp1r3cb | protein phosphatase 1, regulatory subunit 3Cb |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378695 | ins.L | insulin L homeolog | Xenopus laevis (African clawed frog) | |
| 378696 | ins.S | insulin S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 394283 | sdc2.S | syndecan 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 398006 | insr.L | insulin receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 179991 | zmp-4 | Hemopexin;Peptidase metallopeptidase domain-containing protein | |
| 180033 | cpr-3 | Cathepsin B-like cysteine proteinase 3 | |
| 180042 | dpf-1 | Dipeptidyl peptidase family member 1 | |
| 180111 | cpl-1 | Cathepsin L-like | |
| 180289 | mrp-7 | Multidrug resistance protein mrp-7 | |
| 180351 | W01F3.2 | Uncharacterized protein | |
| 180364 | T03D8.6 | Gamma-glutamyltransferase;Gamma-glutamyltranspeptidase 1 | |
| 180409 | mrp-1 | Multidrug resistance-associated protein 1 | |
| 180628 | cht-1 | putative endochitinase | |
| 180780 | acn-1 | Inactive angiotensin-converting enzyme-related protein |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850369 | ADP1 | putative ATP-dependent permease ADP1 | |
| 850391 | NPP1 | nucleotide diphosphatase/phosphodiesterase NPP1 | |
| 850614 | HXK1 | hexokinase 1 | |
| 850645 | BPT1 | ATP-binding cassette bilirubin transporter BPT1 | |
| 850678 | YBT1 | bile acid-transporting ATPase YBT1 | |
| 850886 | ATG26 | sterol 3-beta-glucosyltransferase | |
| 850979 | PIG1 | protein phosphatase regulator PIG1 | |
| 851006 | ECM38 | gamma-glutamyltransferase | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000855 | Insulin resistance |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
| 2645 | GCK | glucokinase |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 3990 | LIPC | lipase C, hepatic type |
