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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
obesity
Summary
- Definition
- An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
- Super Class
- overnutrition
External Links
- Disease Ontology
- DOID:9970
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
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- 3766125
- 3821619
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- 3511747
- 2681522
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- 2653295
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- 2388265
- 3589409
- 3655811
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- 3611807
- 2174793
- 3586756
- 3582615
- 3580003
- 3579026
- 3577766
- 3526863
- 3511748
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 3990 | LIPC | lipase C, hepatic type | |
| 3992 | FADS1 | fatty acid desaturase 1 | |
| 4023 | LPL | lipoprotein lipase | |
| 4137 | MAPT | microtubule associated protein tau | |
| 4153 | MBL2 | mannose binding lectin 2 | |
| 4159 | MC3R | melanocortin 3 receptor | |
| 4160 | MC4R | melanocortin 4 receptor | |
| 4282 | MIF | macrophage migration inhibitory factor | |
| 4306 | NR3C2 | nuclear receptor subfamily 3 group C member 2 | |
| 4318 | MMP9 | matrix metallopeptidase 9 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11303 | Abca1 | ATP-binding cassette, sub-family A member 1 | |
| 11421 | Ace | angiotensin I converting enzyme | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11520 | Plin2 | perilipin 2 | |
| 11537 | Cfd | complement factor D | |
| 11539 | Adora1 | adenosine A1 receptor | |
| 11555 | Adrb2 | adrenergic receptor, beta 2 | |
| 11556 | Adrb3 | adrenergic receptor, beta 3 | |
| 11596 | Ager | advanced glycosylation end product-specific receptor | |
| 11625 | Ahsg | alpha-2-HS-glycoprotein |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24152 | Asip | agouti signaling protein | |
| 24179 | Agt | angiotensinogen | |
| 24217 | Atp4b | ATPase H+/K+ transporting subunit beta | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24232 | C3 | complement C3 | |
| 24267 | Comt | catechol-O-methyltransferase | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24318 | Drd2 | dopamine receptor D2 | |
| 24367 | Fgg | fibrinogen gamma chain | |
| 24377 | G6pd | glucose-6-phosphate dehydrogenase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31002 | Appl | beta amyloid protein precursor-like | |
| 31017 | sdk | sidekick | |
| 31234 | Pdfr | Pigment-dispersing factor receptor | |
| 31293 | N | Notch | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 32556 | Stim | Stromal interaction molecule | |
| 32974 | Zw | Zwischenferment | |
| 33007 | Dop2R | Dopamine 2-like receptor | |
| 33245 | ds | dachsous | |
| 33627 | ft | fat |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30128 | wnt1 | wingless-type MMTV integration site family, member 1 | |
| 30308 | wnt10b | wingless-type MMTV integration site family, member 10b | |
| 30686 | myca | MYC proto-oncogene, bHLH transcription factor a | |
| 30705 | fgfr1a | fibroblast growth factor receptor 1a | |
| 30718 | notch1a | notch receptor 1a | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 286833 | mc4r | melanocortin 4 receptor | |
| 317743 | gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 393141 | mycb | MYC proto-oncogene, bHLH transcription factor b | |
| 406207 | mttp | microsomal triglyceride transfer protein |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 399444 | fgfr1.L | fibroblast growth factor receptor 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 432172 | akt2.S | v-akt murine thymoma viral oncogene homolog 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 448238 | cadm2 | cell adhesion molecule 2 | Xenopus tropicalis (tropical clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 494791 | cfd.L | complement factor D L homeolog | Xenopus laevis (African clawed frog) | |
| 548648 | fgfr1 | fibroblast growth factor receptor 1 | Xenopus tropicalis (tropical clawed frog) | |
| 100037842 | notch1 | notch 1 receptor | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171994 | lin-44 | Abnormal cell lineage protein 44 | |
| 171999 | poml-2 | Arylesterase | |
| 173169 | eif-6 | Eukaryotic translation initiation factor 6 | |
| 173399 | cwn-1 | Protein Wnt-1 | |
| 174578 | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4 | |
| 174603 | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1 | |
| 174685 | ptp-3 | Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase | |
| 175201 | stim-1 | Stromal interaction molecule 1 | |
| 175410 | daf-2 | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 855247 | HFA1 | acetyl-CoA carboxylase HFA1 | |
| 855301 | TRM732 | tRNA methylation protein TRM732 | |
| 855480 | ZWF1 | glucose-6-phosphate dehydrogenase | |
| 855483 | KEX2 | kexin KEX2 | |
| 855949 | PEP4 | proteinase A | |
| 856020 | SEC16 | Sec16p | |
| 856294 | RHO1 | Rho family GTPase RHO1 | |
| 856533 | ECM14 | putative metallocarboxypeptidase | |
| 856699 | NPP2 | nucleotide diphosphatase/phosphodiesterase NPP2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0010982 | Polygenic inheritance |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0012340 | Decreased resting energy expenditure |
| HP:0001513 | Obesity |
