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MIRAGE
obesity

Summary
Definition
An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Super Class
overnutrition
Disease Ontology
DOID:9970
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 72 in total
Gene ID Gene Symbol Description Source
19 ABCA1 ATP binding cassette subfamily A member 1
154 ADRB2 adrenoceptor beta 2
155 ADRB3 adrenoceptor beta 3
183 AGT angiotensinogen
347 APOD apolipoprotein D
367 AR androgen receptor
583 BBS2 Bardet-Biedl syndrome 2
886 CCKAR cholecystokinin A receptor
1268 CNR1 cannabinoid receptor 1
1312 COMT catechol-O-methyltransferase
Displaying entries 11 - 18 of 18 in total
Gene ID Gene Symbol Description Source
18759 Prkci protein kinase C, iota
18976 Pomc pro-opiomelanocortin-alpha
20614 Snap25 synaptosomal-associated protein 25
50518 a nonagouti
70726 Angptl6 angiopoietin-like 6
72774 Neil1 nei endonuclease VIII-like 1 (E. coli)
104263 Kdm3a lysine (K)-specific demethylase 3A
236266 Alms1 ALMS1, centrosome and basal body associated
Displaying entries 21 - 25 of 25 in total
Gene ID Gene Symbol Description Source
85268 Hrh3 histamine receptor H3
113959 C5ar1 complement C5a receptor 1
171374 Atp5f1b ATP synthase F1 subunit beta
245965 Atp5f1d ATP synthase F1 subunit delta
246075 Prlhr prolactin releasing hormone receptor
Displaying all 3 entries
Gene ID Gene Symbol Description Source
173169 eif-6 Eukaryotic translation initiation factor 6
176286 glp-1 glp-1/Notch intracellular domain
177850 gon-1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein
Related Glycoprotein
The Human Phenotype Ontology
Displaying all 5 entries
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0010982 Polygenic inheritance
HP:0000006 Autosomal dominant inheritance
HP:0012340 Decreased resting energy expenditure
HP:0001513 Obesity
Displaying all 2 entries
Gene ID Gene Symbol Description
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
9672 SDC3 syndecan 3
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025