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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 6532 | SLC6A4 | solute carrier family 6 member 4 | |
| 6649 | SOD3 | superoxide dismutase 3 | |
| 6772 | STAT1 | signal transducer and activator of transcription 1 | |
| 6775 | STAT4 | signal transducer and activator of transcription 4 | |
| 7040 | TGFB1 | transforming growth factor beta 1 | |
| 7076 | TIMP1 | TIMP metallopeptidase inhibitor 1 | |
| 7099 | TLR4 | toll like receptor 4 | |
| 7124 | TNF | tumor necrosis factor | |
| 7132 | TNFRSF1A | TNF receptor superfamily member 1A | |
| 7133 | TNFRSF1B | TNF receptor superfamily member 1B |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12273 | C5ar1 | complement component 5a receptor 1 | |
| 12477 | Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | |
| 12487 | Cd28 | CD28 antigen | |
| 12519 | Cd80 | CD80 antigen | |
| 12524 | Cd86 | CD86 antigen | |
| 12638 | Cftr | cystic fibrosis transmembrane conductance regulator | |
| 12654 | Chi3l1 | chitinase 3 like 1 | |
| 12671 | Chrm3 | cholinergic receptor, muscarinic 3, cardiac | |
| 12765 | Cxcr2 | C-X-C motif chemokine receptor 2 | |
| 12766 | Cxcr3 | C-X-C motif chemokine receptor 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24232 | C3 | complement C3 | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24260 | Chrm3 | cholinergic receptor, muscarinic 3 | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24297 | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24407 | Grik5 | glutamate ionotropic receptor kainate type subunit 5 | |
| 24410 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | |
| 24464 | Hp | haptoglobin | |
| 24536 | Lepr | leptin receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 37455 | Egfr | Epidermal growth factor receptor | |
| 37892 | mAChR-A | muscarinic Acetylcholine Receptor, A-type | |
| 37895 | SerT | Serotonin transporter | |
| 38326 | Pxn | Peroxidasin | |
| 38545 | nAChRbeta1 | nicotinic Acetylcholine Receptor beta1 | |
| 39557 | Hsp110 | Heat shock protein 110 | |
| 41549 | Octbeta2R | Octopamine beta2 receptor | |
| 42918 | nAChRalpha1 | nicotinic Acetylcholine Receptor alpha1 | |
| 42919 | nAChRalpha2 | nicotinic Acetylcholine Receptor alpha2 | |
| 42920 | nAChRbeta2 | nicotinic Acetylcholine Receptor beta2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 791973 | cxcr3.2 | chemokine (C-X-C motif) receptor 3, tandem duplicate 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 108697308 | adrb1.L | adrenoceptor beta 1 L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171999 | poml-2 | Arylesterase | |
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 172449 | glr-3 | Glutamate receptor ionotropic, kainate glr-3 | |
| 174262 | acr-7 | Acetylcholine receptor subunit alpha-type acr-7 | |
| 174462 | let-23 | Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase | |
| 175072 | eat-2 | Neuronal acetylcholine receptor subunit eat-2 | |
| 175182 | ver-1 | Protein ver-1 | |
| 175383 | zmp-2 | Matrix metalloproteinase-B | |
| 177343 | skn-1 | BZIP domain-containing protein;Protein skinhead-1 |
