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chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 1139 | CHRNA7 | cholinergic receptor nicotinic alpha 7 subunit | |
| 1179 | CLCA1 | chloride channel accessory 1 | |
| 1394 | CRHR1 | corticotropin releasing hormone receptor 1 | |
| 1493 | CTLA4 | cytotoxic T-lymphocyte associated protein 4 | |
| 1543 | CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | |
| 1544 | CYP1A2 | cytochrome P450 family 1 subfamily A member 2 | |
| 1571 | CYP2E1 | cytochrome P450 family 2 subfamily E member 1 | |
| 1636 | ACE | angiotensin I converting enzyme | |
| 1672 | DEFB1 | defensin beta 1 | |
| 1906 | EDN1 | endothelin 1 |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| A8K7I4 | Calcium-activated chloride channel regulator 1 | |
| O00206 | Toll-like receptor 4 | |
| P01009 | Alpha-1-antitrypsin | |
| P01011 | Alpha-1-antichymotrypsin | |
| P01137 | Transforming growth factor beta-1 proprotein | |
| P01375 | Tumor necrosis factor | |
| P02774 | Vitamin D-binding protein | |
| P04150 | Glucocorticoid receptor | |
| P04440 | HLA class II histocompatibility antigen, DP beta 1 chain | |
| P04798 | Cytochrome P450 1A1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P17246 | Transforming growth factor beta-1 proprotein |
