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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
obesity
Summary
- Definition
- An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
- Super Class
- overnutrition
External Links
- Disease Ontology
- DOID:9970
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
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- 3766125
- 3821619
- 3821616
- 3817475
- 3799316
- 3784993
- 3784991
- 3773447
- 3772367
- 3822317
- 3766122
- 3721145
- 3715252
- 3694548
- 3689720
- 3664551
- 3664276
- 3655835
- 5515728
- 7545554
- 7545550
- 7545546
- 6273993
- 5828524
- 5766495
- 5763310
- 5763241
- 3655832
- 5447549
- 5300906
- 3850836
- 3847120
- 3840234
- 3832410
- 3822318
- 3033164
- 3511746
- 3055585
- 3055584
- 3053798
- 3041643
- 3036853
- 3036852
- 3033165
- 3511747
- 2681522
- 2680503
- 2669229
- 2663736
- 2654708
- 2653295
- 2651886
- 2388265
- 3589409
- 3655811
- 3639781
- 3639355
- 3639354
- 3629805
- 3623749
- 3620067
- 3611807
- 2174793
- 3586756
- 3582615
- 3580003
- 3579026
- 3577766
- 3526863
- 3511748
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 10874 | NMU | neuromedin U | |
| 10891 | PPARGC1A | PPARG coactivator 1 alpha | |
| 11095 | ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif 8 | |
| 11132 | CAPN10 | calpain 10 | |
| 11254 | SLC6A14 | solute carrier family 6 member 14 | |
| 11255 | HRH3 | histamine receptor H3 | |
| 22852 | ANKRD26 | ankyrin repeat domain containing 26 | |
| 23038 | WDTC1 | WD and tetratricopeptide repeats 1 | |
| 23129 | PLXND1 | plexin D1 | |
| 23175 | LPIN1 | lipin 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 21413 | Tcf4 | transcription factor 4 | |
| 21416 | Tcf7l2 | transcription factor 7 like 2, T cell specific, HMG box | |
| 21803 | Tgfb1 | transforming growth factor, beta 1 | |
| 21823 | Th | tyrosine hydroxylase | |
| 21824 | Thbd | thrombomodulin | |
| 21825 | Thbs1 | thrombospondin 1 | |
| 21857 | Timp1 | tissue inhibitor of metalloproteinase 1 | |
| 21898 | Tlr4 | toll-like receptor 4 | |
| 21926 | Tnf | tumor necrosis factor | |
| 21937 | Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24152 | Asip | agouti signaling protein | |
| 24179 | Agt | angiotensinogen | |
| 24217 | Atp4b | ATPase H+/K+ transporting subunit beta | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24232 | C3 | complement C3 | |
| 24267 | Comt | catechol-O-methyltransferase | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24318 | Drd2 | dopamine receptor D2 | |
| 24367 | Fgg | fibrinogen gamma chain | |
| 24377 | G6pd | glucose-6-phosphate dehydrogenase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30128 | wnt1 | wingless-type MMTV integration site family, member 1 | |
| 30308 | wnt10b | wingless-type MMTV integration site family, member 10b | |
| 30686 | myca | MYC proto-oncogene, bHLH transcription factor a | |
| 30705 | fgfr1a | fibroblast growth factor receptor 1a | |
| 30718 | notch1a | notch receptor 1a | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 286833 | mc4r | melanocortin 4 receptor | |
| 317743 | gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 393141 | mycb | MYC proto-oncogene, bHLH transcription factor b | |
| 406207 | mttp | microsomal triglyceride transfer protein |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 373802 | pomc.S | proopiomelanocortin S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378693 | npy2r.S | neuropeptide Y receptor Y2 S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380532 | pomc.L | proopiomelanocortin L homeolog | Xenopus laevis (African clawed frog) | |
| 394945 | cfd | complement factor D | Xenopus tropicalis (tropical clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 397782 | fgfr1.S | fibroblast growth factor receptor 1 S homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171994 | lin-44 | Abnormal cell lineage protein 44 | |
| 171999 | poml-2 | Arylesterase | |
| 173169 | eif-6 | Eukaryotic translation initiation factor 6 | |
| 173399 | cwn-1 | Protein Wnt-1 | |
| 174578 | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4 | |
| 174603 | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1 | |
| 174685 | ptp-3 | Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase | |
| 175201 | stim-1 | Stromal interaction molecule 1 | |
| 175410 | daf-2 | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850391 | NPP1 | nucleotide diphosphatase/phosphodiesterase NPP1 | |
| 850442 | SRB8 | Srb8p | |
| 850614 | HXK1 | hexokinase 1 | |
| 850647 | PUF3 | mRNA-binding protein PUF3 | |
| 851241 | CNE1 | calnexin | |
| 851888 | DPL1 | sphinganine-1-phosphate aldolase DPL1 | |
| 851974 | YPR1 | trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 | |
| 852053 | SSN2 | Ssn2p | |
| 852102 | IZH1 | PAQR-type receptor |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0010982 | Polygenic inheritance |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0012340 | Decreased resting energy expenditure |
| HP:0001513 | Obesity |
